Jon Sen
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View article: Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: a prospective cohort study
Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: a prospective cohort study Open
Introduction: Assessment of the pupillary light reflex (PLR) is a key part of intensive care monitoring of neurosurgical patients, particularly for detecting abnormalities in intracranial pressure (ICP). Quantitative pupillometry using a h…
View article: A benchtop brain injury model using resected donor tissue from patients with Chiari malformation
A benchtop brain injury model using resected donor tissue from patients with Chiari malformation Open
The use of live animal models for testing new therapies for brain and spinal cord repair is a controversial area. Live animal models have associated ethical issues and scientific concerns regarding the predictability of human responses. Al…
View article: Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke
Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke Open
Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and cognitive deficits. Despite promising pre-clinical studies, clin…
View article: Susceptibility vessel sign as a predictor for recanalization and clinical outcome in acute ischaemic stroke: A Systematic Review and Meta-analysis
Susceptibility vessel sign as a predictor for recanalization and clinical outcome in acute ischaemic stroke: A Systematic Review and Meta-analysis Open
T2 * -weighted MRI using GRE and SWI sequences can potentially prognosticate the recanalization rate and clinical outcomes in patients with acute ischaemic stroke, using susceptibility vessel sign (SVS) and prominent hypointense vessel sig…
View article: Neurosurgical grade biomaterial, DuraGenTM, offers a promising matrix for protected delivery of neural stem cells in clinical cell therapies
Neurosurgical grade biomaterial, DuraGenTM, offers a promising matrix for protected delivery of neural stem cells in clinical cell therapies Open
with evidence of simple neural network formation within the matrix.
View article: A fusion of minicircle DNA and nanoparticle delivery technologies facilitates therapeutic genetic engineering of autologous canine olfactory mucosal cells
A fusion of minicircle DNA and nanoparticle delivery technologies facilitates therapeutic genetic engineering of autologous canine olfactory mucosal cells Open
Olfactory ensheathing cells (OECs) promote axonal regeneration and improve locomotor function when transplanted into the injured spinal cord. A recent clinical trial demonstrated improved motor function in domestic dogs with spinal injury …