Jon Wade
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View article: Red cell rheology predicts acute chest syndrome and vaso-occlusive events in sickle cell disease
Red cell rheology predicts acute chest syndrome and vaso-occlusive events in sickle cell disease Open
Sickle cell disease (SCD) is an autosomal recessive disorder characterized by rigid, poorly deformable red blood cells (RBC); worsening with hypoxia induced polymerization of sickle hemoglobin (HbS), contributing to potentially life-threat…
View article: Optimization of stem cell fitness and mobilization using moderate transfusion and an oral anti-sickling agent in the sickle mouse model.
Optimization of stem cell fitness and mobilization using moderate transfusion and an oral anti-sickling agent in the sickle mouse model. Open
Ex vivo gene therapy (GT) can transform the lives of people with sickle cell disease (SCD). However, GT relies on mobilization of sufficient quality and quantity of hematopoietic stem cells (HSCs). HSC quality is compromised by stress hema…
View article: Sight: Sickle cell identification from general hematological testing, a machine learning approach for rapid screening in emergency medicine
Sight: Sickle cell identification from general hematological testing, a machine learning approach for rapid screening in emergency medicine Open
Background: Rapid and accurate identification of sickle cell disease (SCD) is crucial in emergency medicine, with the chronic complications of SCD making clinical management profoundly different for SCD patients compared to non-SCD or sick…
View article: In vitro and In Vivo FOXO3 dependent induction of fetal hemoglobin
In vitro and In Vivo FOXO3 dependent induction of fetal hemoglobin Open
Background: Induction of fetal hemoglobin (HbF) is a key therapeutic strategy to treat sickle cell disease (SCD). Unfortunately, the only widely used therapy to induce HbF, hydroxyurea (HU), is clinically effective in only half of adults w…
View article: Use of the microfluidic impedance red cell assay in sickle cell disease
Use of the microfluidic impedance red cell assay in sickle cell disease Open
In sickle cell disease (SCD), red blood cells (RBCs) are poorly deformable, even under normoxia (NOI). With deoxygenation, deformability of sickle RBCs is further reduced due to polymerization of hemoglobin S (HbS). Rigid, poorly deformabl…
View article: Bivalent Surface Attachment via Cysteine Thiol Results in Efficient and Stereoselective Abiotic Peptide Synthesis
Bivalent Surface Attachment via Cysteine Thiol Results in Efficient and Stereoselective Abiotic Peptide Synthesis Open
Surface-catalyzed peptide bond formation may have been an important source of peptides for abiogenesis, but model peptide synthesis reactions using the consensus set of 10 abiotic amino acids give only modest rates of peptide bond formatio…
View article: Rapid and precise quantification of lymphocyte iron content by single cell inductively coupled plasma mass spectrometry
Rapid and precise quantification of lymphocyte iron content by single cell inductively coupled plasma mass spectrometry Open
Metals facilitate catalysis during cellular metabolism, but heterogeneity of metal content at single-cell level within and between cell populations is poorly characterized. This is important because deficiencies of biometals, for example i…
View article: Earth’s core may have segregated at low pressure
Earth’s core may have segregated at low pressure Open
The current, widely accepted model of terrestrial accretion is that proto-Earth began as a small reduced inner solar system body and grew by adding a mixture of reduced, metal-rich and oxidised (outer solar system) metal-poor bodies with o…
View article: Stereoselective peptide synthesis in alkaline hydrothermal vent conditions
Stereoselective peptide synthesis in alkaline hydrothermal vent conditions Open
Modern proteins are composed exclusively of L-amino acids but the origin of L-stereospecificity is unresolved. Carbonaceous meteorites were a significant source of organic matter on early Earth and commonly contain ten proteogenic amino ac…
View article: Stereoselective peptide synthesis in alkaline hydrothermal vent conditions
Stereoselective peptide synthesis in alkaline hydrothermal vent conditions Open
Modern proteins are composed exclusively of L-amino acids but the origin of L-stereospecificity is unresolved. Carbonaceous meteorites were a significant source of organic matter on early Earth and commonly contain ten proteogenic amino ac…
View article: Mantle overturn drove early lunar volcanism and the lunar dynamo during the high intensity epoch
Mantle overturn drove early lunar volcanism and the lunar dynamo during the high intensity epoch Open
Generation of an apparently long-lived lunar magnetic field is a longstanding controversy. Palaeomagnetic studies provide conflicting evidence for both strong intrinsic fields (> 53 µT)1–6 and null fields7 between 1.92–4.25 billion years (…
View article: The Burmese Jade Mines belt: origins of jadeitites, serpentinites, and ophiolitic peridotites and gabbros
The Burmese Jade Mines belt: origins of jadeitites, serpentinites, and ophiolitic peridotites and gabbros Open
Ophiolitic peridotites in Myanmar (Burma) occur along three major tectonic zones: the Kaleymyo–Nagaland suture along the Indo-Burman Ranges, the Jade Mines belt and the Tagaung–Mytkyina belt. These belts all show harzburgite–lherzolite–dun…
View article: How reliable is µXRF core scanning at detecting tephra layers in sedimentary records? A case study using the Lake Suigetsu archive (central Japan)
How reliable is µXRF core scanning at detecting tephra layers in sedimentary records? A case study using the Lake Suigetsu archive (central Japan) Open
Here, we evaluate the ability of micro X‐ray fluorescence (µXRF) core scanning to identify non‐visible volcanic ash (cryptotephra) layers in sedimentary records. Its suitability is assessed using the annually resolved lacustrine sediments …
View article: Planets or asteroids? A geochemical method to constrain the masses of White Dwarf pollutants
Planets or asteroids? A geochemical method to constrain the masses of White Dwarf pollutants Open
Polluted white dwarfs that have accreted planetary material provide a unique opportunity to probe the geology of exoplanetary systems. However, the nature of the bodies that pollute white dwarfs is not well understood: are they small aster…
View article: Temporal variation of planetary iron as a driver of evolution
Temporal variation of planetary iron as a driver of evolution Open
Iron is an irreplaceable component of proteins and enzyme systems required for life. This need for iron is a well-characterized evolutionary mechanism for genetic selection. However, there is limited consideration of how iron bioavailabili…
View article: Planets or asteroids? A geochemical method to constrain the masses of\n White Dwarf pollutants
Planets or asteroids? A geochemical method to constrain the masses of\n White Dwarf pollutants Open
Polluted white dwarfs that have accreted planetary material provide a unique\nopportunity to probe the geology of exoplanetary systems. However, the nature\nof the bodies which pollute white dwarfs is not well understood: are they small\na…
View article: Seeing through metamorphic overprints in Archean granulites: Combined high-resolution thermometry and phase equilibrium modeling of the Lewisian Complex, Scotland
Seeing through metamorphic overprints in Archean granulites: Combined high-resolution thermometry and phase equilibrium modeling of the Lewisian Complex, Scotland Open
The Lewisian Complex in northwest Scotland presents a record of the transition from the Neo-Archean to the Paleoproterozoic. However, this record is complicated by a long and varied history after peak metamorphism that has erased and/or pa…
View article: Chromium, Nickel and Iron as clues to the formation histories of exoplanetary bodies
Chromium, Nickel and Iron as clues to the formation histories of exoplanetary bodies Open
<p>We are now entering an era of rocky exoplanet detection. To determine whether an exoplanet is &#8216;Earth-like&#8217;, we must estimate not only its mass, radius and insolation, but also its geological composition. These …
View article: Subduction-Driven Volatile Recycling: A Global Mass Balance
Subduction-Driven Volatile Recycling: A Global Mass Balance Open
Volatile elements (water, carbon, nitrogen, sulfur, halogens, and noble gases) played an essential role in the secular evolution of the solid Earth and emergence of life. Here we provide an overview of Earth's volatile inventories and desc…
View article: Chromium, Nickel and Iron as clues to the formation histories of exoplanetary bodies
Chromium, Nickel and Iron as clues to the formation histories of exoplanetary bodies Open
Cr, Ni and Fe abundances trace the process of core-mantle differentiation. While Cr and Ni are both siderophilic (iron-loving), their exact abundances relative to Fe in both the core and the mantle depend on the conditions under which core…
View article: The Cycladic Blueschist Unit on Tinos, Greece: Cold NE Subduction and SW Directed Extrusion of the Cycladic Continental Margin Under the Tsiknias Ophiolite
The Cycladic Blueschist Unit on Tinos, Greece: Cold NE Subduction and SW Directed Extrusion of the Cycladic Continental Margin Under the Tsiknias Ophiolite Open
High pressure‐low temperature ( HP‐LT ) metamorphic rocks structurally beneath the Tsiknias Ophiolite make up the interior of Tinos Island, Greece, but their relationship with the overlying ophiolite is poorly understood. Here, new field o…
View article: The Cycladic subduction zone from birth to death: Insights into the subduction cooling rate conundrum
The Cycladic subduction zone from birth to death: Insights into the subduction cooling rate conundrum Open
<p>The Attic-Cycladic Massif (ACM) preserves the entire evolution of a NE dipping subduction zone.&#160; This includes the intra-oceanic subduction initiation associated with ophiolite obduction and formation of a metamorphic sol…
View article: The effect of core segregation on the Cu and Zn isotope composition of the silicate Moon
The effect of core segregation on the Cu and Zn isotope composition of the silicate Moon Open
Compared to elements of similar volatility, such as Rb, Ga and K, the bulk silicate Moon (BSM) exhibits significant enrichment in the heavy isotopes of Zn and Cu. However, both elements display a greater affinity for lunar sulfide phases t…