Jonas Ahlers
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View article: Prevalence of chronic conditions and influenza vaccination coverage rates in Germany: Results of a health insurance claims data analysis
Prevalence of chronic conditions and influenza vaccination coverage rates in Germany: Results of a health insurance claims data analysis Open
Background The significant annual burden caused by seasonal influenza has led to global calls for increased influenza vaccination coverage rates (VCRs). We aimed to estimate the proportion of the German population at high risk of serious i…
View article: Sarilumab reduces disease activity in rheumatoid arthritis patients with inadequate response to janus kinase inhibitors or tocilizumab in regular care in Germany
Sarilumab reduces disease activity in rheumatoid arthritis patients with inadequate response to janus kinase inhibitors or tocilizumab in regular care in Germany Open
Objectives The aim was to evaluate the safety and effectiveness of sarilumab in RA patients after inadequate response (IR) to janus kinase inhibitors (JAKi) and tocilizumab. Methods The prospective, observational, 24-month single-arm PROSA…
View article: Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction
Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction Open
Although it is well-known that limited local mutations of enzymes, such as matrix metalloproteinases (MMPs), may change enzyme activity by orders of magnitude as well as its stability, the completely rational design of proteins is still ch…