Jonas Euchner
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View article: Mapping membrane biophysical nano-environments
Mapping membrane biophysical nano-environments Open
View article: ProDOL: a general method to determine the degree of labeling for staining optimization and molecular counting
ProDOL: a general method to determine the degree of labeling for staining optimization and molecular counting Open
Determining the label to target ratio, also known as the degree of labeling (DOL), is crucial for quantitative fluorescence microscopy and a high DOL with minimal unspecific labeling is beneficial for fluorescence microscopy in general. Ye…
View article: Generation of a human iPSC-derived cardiomyocyte/fibroblast engineered heart tissue model
Generation of a human iPSC-derived cardiomyocyte/fibroblast engineered heart tissue model Open
Animal models have proven integral to broadening our understanding of complex cardiac diseases but have been hampered by significant species-dependent differences in cellular physiology. Human-induced pluripotent stem cell-derived cardiomy…
View article: Generation of a human iPSC-derived cardiomyocyte/fibroblast engineered heart tissue model
Generation of a human iPSC-derived cardiomyocyte/fibroblast engineered heart tissue model Open
Animal models have proven integral to broadening our understanding of complex cardiac diseases but have been hampered by significant species-dependent differences in cellular physiology. Human-induced pluripotent stem cell-derived cardiomy…
View article: A General Method to Accurately Count Molecular Complexes and Determine the Degree of Labelling in Cells Using Protein Tags
A General Method to Accurately Count Molecular Complexes and Determine the Degree of Labelling in Cells Using Protein Tags Open
Determining the label to target ratio, also known as degree of labelling (DOL), is crucial for quantitative fluorescence microscopy and a high DOL with minimal unspecific labelling is beneficial for fluorescence microscopy in general. Yet,…
View article: Photobleaching step analysis for robust determination of protein complex stoichiometries
Photobleaching step analysis for robust determination of protein complex stoichiometries Open
A reliable and automated single-molecule photobleaching step analysis is presented for protein copy number quantification in complexes containing up to 35 labeled proteins in situ. A combined approach for robust and efficient data analysis…
View article: Photobleaching step analysis for robust determination of protein complex stoichiometries
Photobleaching step analysis for robust determination of protein complex stoichiometries Open
The composition of cellular structures on the nanoscale is a key determinant of macroscopic functions in cell biology and beyond. Different fluorescence single-molecule techniques have proven ideally suited for measuring protein copy numbe…
View article: Green- to far-red-emitting fluorogenic tetrazine probes – synthetic access and no-wash protein imaging inside living cells
Green- to far-red-emitting fluorogenic tetrazine probes – synthetic access and no-wash protein imaging inside living cells Open
Fluorogenic probes for bioorthogonal labeling chemistry are highly beneficial to reduce background signal in fluorescence microscopy imaging.