Jonas F. Hummel
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View article: Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis
Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis Open
Immune-mediated nephritis is a leading cause of acute kidney injury and chronic kidney disease. While the role of B cells and antibodies has been extensively investigated in the past, the advent of immune-checkpoint inhibitors has led to a…
View article: The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection
The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection Open
View article: Clustering Approaches for Gait Analysis within Neurological Disorders: A Narrative Review
Clustering Approaches for Gait Analysis within Neurological Disorders: A Narrative Review Open
Background: The prevalence of neurological disorders is increasing, underscoring the importance of objective gait analysis to help clinicians identify specific deficits. Nevertheless, existing technological solutions for gait analysis ofte…
View article: Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals
Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals Open
Development of T cells is controlled by the signal strength of the TCR. The scaffold protein kinase D–interacting substrate of 220 kilodalton (Kidins220) binds to the TCR; however, its role in T cell development was unknown. Here, we show …
View article: Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4+ T cells
Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4+ T cells Open
The T-box transcription factors T-bet and Eomesodermin regulate type 1 immune responses in innate and adaptive lymphocytes. T-bet is widely expressed in the immune system but was initially identified as the lineage-specifying transcription…
View article: Kidins220 promotes thymic iNKT cell development by reducing TCR signals, but enhances TCR signals in splenic iNKT cells
Kidins220 promotes thymic iNKT cell development by reducing TCR signals, but enhances TCR signals in splenic iNKT cells Open
The stepwise development of thymic invariant natural killer T (iNKT) cells is controlled by the TCR signal strength. The scaffold protein Kinase D interacting substrate of 220 kDa (Kidins220) binds to the TCR regulating TCR signaling. T ce…
View article: <i>IFNL4</i> rs368234815 polymorphism does not predict risk of BK virus associated nephropathy after living‐donor kidney transplant: A case‐control study
<i>IFNL4</i> rs368234815 polymorphism does not predict risk of BK virus associated nephropathy after living‐donor kidney transplant: A case‐control study Open
Background BK polyoma virus (BKPyV) associated nephropathy (BKPyVAN) is a major cause of kidney graft loss in renal transplant patients. Interferons (IFNs) are an important innate immune response against viral infections and genetic polymo…
View article: Kidins220 Promotes Thymic iNKT Cell Development by Reducing TCR Signals, But Enhances TCR Signals in Splenic iNKT Cells
Kidins220 Promotes Thymic iNKT Cell Development by Reducing TCR Signals, But Enhances TCR Signals in Splenic iNKT Cells Open
View article: Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells
Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells Open
The two T-box transcription factors T-bet and Eomesodermin (Eomes) are important regulators of cytotoxic lymphocytes (CTLs), such as activated CD8 T cells, which are essential in the fight against intracellular pathogens and tumors. Both t…
View article: Single-cell RNA-sequencing identifies the developmental trajectory of C-Myc-dependent NK1.1− T-bet+ intraepithelial lymphocyte precursors
Single-cell RNA-sequencing identifies the developmental trajectory of C-Myc-dependent NK1.1− T-bet+ intraepithelial lymphocyte precursors Open
Natural intraepithelial lymphocytes (IELs) are thymus-derived adaptive immune cells, which are important contributors to intestinal immune homeostasis. Similar to other innate-like T cells, they are induced in the thymus through high-avidi…
View article: A committed postselection precursor to natural TCRαβ+ intraepithelial lymphocytes
A committed postselection precursor to natural TCRαβ+ intraepithelial lymphocytes Open
View article: A dual‐fluorescence reporter in the <i>Eomes</i> locus for live imaging and medium‐term lineage tracing
A dual‐fluorescence reporter in the <i>Eomes</i> locus for live imaging and medium‐term lineage tracing Open
Summary The T‐box transcription factor Eomes (also known as Tbr2 ) shows short‐lived expression in various localized domains of the embryo, including epiblast cells during gastrulation and intermediate progenitor cells in the cerebral cort…
View article: Human endogenous retrovirus envelope proteins target dendritic cells to suppress T‐cell activation
Human endogenous retrovirus envelope proteins target dendritic cells to suppress T‐cell activation Open
Though mostly defective, human endogenous retroviruses (HERV) can retain open reading frames, which are especially expressed in the placenta. There, the envelope (env) proteins of HERV‐W (Syncytin‐1), HERV‐FRD (Syncytin‐2), and HERV‐K (HML…