Jonas Graf
YOU?
Author Swipe
View article: Symptoms Prior to Diagnosis of Multiple Sclerosis in Individuals Younger Than 18 Years
Symptoms Prior to Diagnosis of Multiple Sclerosis in Individuals Younger Than 18 Years Open
Importance A growing body of literature suggests the presence of a prodromal period with nonspecific signs and symptoms before onset of multiple sclerosis (MS). Objective To systematically assess diseases and symptoms diagnosed in the 5 ye…
Heterophoria in multiple sclerosis patients: a proof of principle cross-sectional study Open
Objectives The pathophysiology of multiple sclerosis (MS) involves inflammatory neurodegeneration in the brainstem, cerebellum, and retina. The clinical relevance of oculomotor involvement in MS, however, remains uncertain. Methods In this…
View article: Multiple sclerosis disease-modifying drug use by immigrants: a real-world study
Multiple sclerosis disease-modifying drug use by immigrants: a real-world study Open
Little is known about disease-modifying drug (DMD) initiation by immigrants with multiple sclerosis (MS) in countries with universal health coverage. We assessed the association between immigration status and DMD use within 5-years after t…
View article: Emergency department use by persons with MS: A population-based descriptive study with a focus on infection-related visits
Emergency department use by persons with MS: A population-based descriptive study with a focus on infection-related visits Open
We described emergency department (ED) visits (all visits and infection-related) by persons with multiple sclerosis (MS) in British Columbia, Canada (1 April 2012 to 31 December 2017). We identified 15,350 MS cases using health administrat…
View article: Disease-Modifying Drug Uptake and Health Service Use in the Ageing MS Population
Disease-Modifying Drug Uptake and Health Service Use in the Ageing MS Population Open
Background Evidence regarding the efficacy or effectiveness of the disease-modifying drugs (DMDs) in the older multiple sclerosis (MS) population is scarce. This has contributed to a lack of evidence-based treatment recommendations for the…
CNS Involvement in Chronic Inflammatory Demyelinating Polyneuropathy: Subtle Retinal Changes in Optical Coherence Tomography. Open
Our data reveal subtle retinal neurodegeneration in patients with CIDP, providing evidence for visual pathway involvement, detectable by OCT. The results need corroboration in independent, larger cohorts.
CNS Involvement in Chronic Inflammatory Demyelinating Polyneuropathy Open
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease primarily affecting the peripheral nervous system. However, several noncontrolled studies have suggested concomitant inflammatory CNS demyelination similar t…
Relapse-independent multiple sclerosis progression under natalizumab Open
The objective of this study was to investigate confirmed progression independent of relapse activity in relapsing-remitting multiple sclerosis patients under long-term natalizumab treatment. We performed a retrospective, cross-sectional st…
Introduction of a rapid sequence induction checklist and its effect on compliance to guidelines and complications Open
Background Current evidence for the conduct of rapid sequence induction (RSI) is weak. This increases the risk of clinicians modifying the RSI procedure according to personal preferences. Checklists may help increase compliance to best pra…
Association of Retinal Layer Thickness With Cognition in Patients With Multiple Sclerosis Open
In patients with MS, at less advanced disease stages, RLT was especially associated with cognitive flexibility promoting OCT as a potential marker advocating further extensive neuropsychological examination.
Targeting B Cells to Modify MS, NMOSD, and MOGAD Open
Ocrelizumab, rituximab, ofatumumab, ublituximab, inebilizumab, and evobrutinib are immunotherapies that target various B cell-related proteins. Most of these treatments have proven efficacy in relapsing and progressive forms of MS and neur…
Targeting B cells to modify MS, NMOSD, and MOGAD Open
Ocrelizumab, rituximab, ofatumumab, ublituximab, inebilizumab, and evobrutinib are immunotherapies that target various B cell-related proteins. Most of these treatments have proven efficacy in relapsing and progressive forms of MS and neur…
Serum neurofilament light chain Open
In patients with stable MS at less advanced disease stages, sNfL did not convincingly relate to cognitive performance, fatigue, depression, or anxiety and thus may not serve as a surrogate biomarker for neuropsychological status in such po…
Retinal layers and visual conductivity changes in a case series of microangiopathic ischemic stroke patients Open
Background It is unknown whether microangiopathic ischemic strokes outside the visual pathway go along with subclinical changes of the retinal structure or the visual system. The objectives of this prospective non-interventional case serie…
View article: Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders
Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders Open
This first longitudinal VEP study of patients with NMOSD provides evidence of progressive VEP latency delay occurring independently of acute ON. Prospective longitudinal studies are needed to corroborate these findings and help to interpre…
Meningitis gone viral: Description of the Echovirus Wave 2013 in Germany Open
BACKGROUND: Aseptic meningitis epidemics may pose various health care challenges. METHODS: We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1st and…
Meningitis gone viral: Description of the Echovirus Wave 2013 in Germany Open
BACKGROUND: Aseptic meningitis epidemics may pose various health care challenges. OBJECTIVE: We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1 st …
Meningitis gone viral: Description of the Echovirus Wave 2013 in Germany Open
BACKGROUND: Aseptic meningitis epidemics may pose various health care challenges. OBJECTIVE: We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1 st …
Meningitis gone viral: Description of the German Echo Wave 2013 Open
BACKGROUND: Aseptic meningitis epidemics may pose various health care challenges. OBJECTIVE: We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1st a…
Multifocal visual evoked potentials in chronic inflammatory demyelinating polyneuropathy Open
Objective Studies using conventional full‐field visual evoked potentials (ffVEP) have reported subtle abnormalities in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We hypothesize that these abnormalities can be d…
Infectious risk stratification in multiple sclerosis patients receiving immunotherapy Open
The increasing number of potent treatments for multiple sclerosis warrants screening for infections. To investigate the prevalence of infections in two independent German patient cohorts with multiple sclerosis/neuromyelitis optica spectru…