Jonas Hahn
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View article: Corrigendum: Oxidative burst-dependent NETosis is implicated in the resolution of necrosis-associated sterile inflammation
Corrigendum: Oxidative burst-dependent NETosis is implicated in the resolution of necrosis-associated sterile inflammation Open
[This corrects the article DOI: 10.3389/fimmu.2016.00557.].
View article: Addendum: Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes
Addendum: Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes Open
Since publication, it was brought to our attention that the Materials and methods section was incomplete and did not include information on the origin, preparation, and handling of the clodronate liposomes
View article: Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes
Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes Open
Clodronate liposomes (Clo-Lip) have been widely used to deplete mononuclear phagocytes (MoPh) to study the function of these cells in vivo. Here, we revisited the effects of Clo-Lip together with genetic models of MoPh deficiency, revealin…
View article: INNOVATIVE BUILDING MATERIALS IN SUB- SAHARAN AFRICA – COMPETITIVE ADVANTAGE FOR CREATING AFFORDABLE HOUSING?
INNOVATIVE BUILDING MATERIALS IN SUB- SAHARAN AFRICA – COMPETITIVE ADVANTAGE FOR CREATING AFFORDABLE HOUSING? Open
Housing is one of the most important basic needs for people. However, in Sub-Saharan Africa, the housing shortage is still increasing. The affordable housing sector, in particular, is reliant on alternatives to conventional house building …
View article: BARRIERS TO THE ADOPTION OF SMART HOUSING CONCEPT IN AFRICAN SMART CITY PROJECTS: CASE OF AKWA MILLENNIUM CITY
BARRIERS TO THE ADOPTION OF SMART HOUSING CONCEPT IN AFRICAN SMART CITY PROJECTS: CASE OF AKWA MILLENNIUM CITY Open
In as much as there is a wealth of research on smart housing, there is limited literature based on empirical findings from Africa. The aim of this paper is to examine barriers to the adoption of smart housing concept in Africa using a case…
View article: The Application of Digital Intelligence to Real Estate Technology Service Quality: A Conceptual Model
The Application of Digital Intelligence to Real Estate Technology Service Quality: A Conceptual Model Open
The occurrence of this present global pandemic has further heightenedthe need for the full adoption and maximisation of digital technologies service-related activities within the built environment. For instance, the disruption in real esta…
View article: Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases
Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases Open
Generalized pustular psoriasis (GPP) is a severe multi-systemic inflammatory disease characterized by neutrophilic pustulosis and triggered by pro-inflammatory IL-36 cytokines in skin. While 19%-41% of affected individuals harbor bi-alleli…
View article: Treatment with DNases rescues hidden neutrophil elastase from aggregated NETs
Treatment with DNases rescues hidden neutrophil elastase from aggregated NETs Open
The release of neutrophil extracellular traps (NETs) is one of the weapons neutrophils have in their armory. NETs consist of extracellular chromatin fibers decorated with a plethora of cytoplasmic and granular proteins, such as the antimic…
View article: Induction of Necrosis in Human Macrophage Cell Lines by Corynebacterium diphtheriae and Corynebacterium ulcerans Strains Isolated from Fatal Cases of Systemic Infections
Induction of Necrosis in Human Macrophage Cell Lines by Corynebacterium diphtheriae and Corynebacterium ulcerans Strains Isolated from Fatal Cases of Systemic Infections Open
When infecting a human host, Corynebacterium diphtheriae and Corynebacterium ulcerans are able to impair macrophage maturation and induce cell death. However, the underlying molecular mechanisms are not well understood. As a framework for …
View article: Low-Dose Radiotherapy Ameliorates Advanced Arthritis in hTNF-α tg Mice by Particularly Positively Impacting on Bone Metabolism
Low-Dose Radiotherapy Ameliorates Advanced Arthritis in hTNF-α tg Mice by Particularly Positively Impacting on Bone Metabolism Open
Inflammation and bone erosion are central in rheumatoid arthritis (RA). Even though effective medications for control and treatment of RA are available, remission is only seen in a subset of patients. Treatment with low-dose radiotherapy (…
View article: Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases
Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases Open
Papillon‐Lefèvre syndrome (PLS) is characterized by nonfunctional neutrophil serine proteases (NSPs) and fulminant periodontal inflammation of unknown cause. Here we investigated neutrophil extracellular trap (NET)‐associated aggregation a…
View article: Chemical Tools for Targeted Amplification of Reactive Oxygen Species in Neutrophils
Chemical Tools for Targeted Amplification of Reactive Oxygen Species in Neutrophils Open
A number of chemical compounds are known, which amplify the availability of reactive oxygen species (ROS) in neutrophils both in vitro and in vivo. They can be roughly classified into NADPH oxidase 2 (NOX2)-dependent and NOX2-independent r…
View article: Guidelines for the use of flow cytometry and cell sorting in immunological studies <sup>*</sup>
Guidelines for the use of flow cytometry and cell sorting in immunological studies <sup>*</sup> Open
The editorial team of the European Journal of
\nImmunology feels it is worthwhile to offer our community guidelines
\nfor the correct use of cytometric techniques in the field of immunology.
View article: Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps
Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps Open
Many effector mechanisms of neutrophils have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Neutrophil extracellular traps (NETs) have been assigned a particularly detrimental role. Here we investigated the func…
View article: Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide
Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide Open
During inflammatory reaction, neutrophils exhibit numerous cellular and immunological functions, notably the formation of neutrophil extracellular traps (NETs) and autophagy. NETs are composed of decondensed chromatin fibers coated with va…
View article: Ménage-à-Trois: The Ratio of Bicarbonate to CO2 and the pH Regulate the Capacity of Neutrophils to Form NETs
Ménage-à-Trois: The Ratio of Bicarbonate to CO2 and the pH Regulate the Capacity of Neutrophils to Form NETs Open
In this study, we identified and characterized the potential of a high ratio of bicarbonate to CO2 and a moderately alkaline pH to render neutrophils prone to undergo neutrophil extracellular trap (NET) formation. Both experimental setting…
View article: Oxidative Burst-Dependent NETosis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation
Oxidative Burst-Dependent NETosis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation Open
Necrosis is associated with a profound inflammatory response. The regulation of necrosis-associated inflammation, particularly the mechanisms responsible for resolution of inflammation is incompletely characterized. Nanoparticles are known…
View article: Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation
Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation Open
Significance The current widespread exposure of humans to natural as well as man-made nanomaterials due to the deployment of nanoparticles (NPs) as food additives, as vaccine- or drug-delivery vehicles, and in diagnostic procedures encoura…