Jonas Himpe
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Fructosyl Amino Oxidase as a Therapeutic Enzyme in Age-Related Macular Degeneration Open
Age-related macular degeneration (AMD) is an age-related disorder that is a global public health problem. The non-enzymatic Maillard reaction results in the formation of advanced glycation end products (AGEs). Accumulation of AGEs in druse…
View article: Topical Application of Deglycating Enzymes as an Alternative Non-Invasive Treatment for Presbyopia
Topical Application of Deglycating Enzymes as an Alternative Non-Invasive Treatment for Presbyopia Open
Presbyopia is an age-related vision disorder that is a global public health problem. Up to 85% of people aged ≥40 years develop presbyopia. In 2015, 1.8 billion people globally had presbyopia. Of those with significant near vision disabili…
View article: C-reactive protein interacts with amphotericin B liposomes and its potential clinical consequences
C-reactive protein interacts with amphotericin B liposomes and its potential clinical consequences Open
Objectives Amphotericin B (AmB) is the gold standard for treating invasive fungal infections. New liposomal-containing AmB formulations have been developed to improve efficacy and tolerability. Serum/plasma C-reactive protein (CRP) values …
Prognostic Features of Near-Infrared Spectroscopy Following Primary Radical Prostatectomy Open
Background: Only a few biomarkers have been evaluated for their prognostic value with regard to biochemical recurrence (BCR) following primary radical prostatectomy. We explored the possibilities of using near-infrared (NIR) spectroscopy a…
View article: A Potential Role for Fructosamine-3-Kinase in Cataract Treatment
A Potential Role for Fructosamine-3-Kinase in Cataract Treatment Open
Cataracts are the major cause of blindness worldwide, largely resulting from aging and diabetes mellitus. Advanced glycation end products (AGEs) have been identified as major contributors in cataract formation because they alter lens prote…
View article: Fructosamine-3-Kinase as a Potential Treatment Option for Age-Related Macular Degeneration
Fructosamine-3-Kinase as a Potential Treatment Option for Age-Related Macular Degeneration Open
Age-related macular degeneration is the leading cause of blindness in the developed world. Since advanced glycation end products (AGEs) are implicated in the pathogenesis of AMD through various lines of evidence, we investigated the potent…
Near‐infrared spectroscopy as a potential non‐invasive tool in the assessment of disease activity in vitiligo patients Open
Vitiligo is a common chronic depigmenting skin disease. We explored the utility of near‐infrared (NIR) spectroscopy in the identification of spectral changes associated with disease activity in vitiligo patients. In vivo spectral measureme…
Carbamoylated Nail Proteins as Assessed by Near-Infrared Analysis Are Associated with Load of Uremic Toxins and Mortality in Hemodialysis Patients Open
Carbamoylation is an important risk factor for accelerated atherogenesis and mortality in patients undergoing hemodialysis (HD). We intended to explore whether carbamoylation as assessed by near-infrared (NIR) analysis of nail proteins is …
UV Fluorescence-Based Determination of Urinary Advanced Glycation End Products in Patients with Chronic Kidney Disease Open
Advanced glycation end products (AGEs) are a class of proteins or lipids that are non-enzymatically glycated and oxidized after contact with aldose sugars. The accumulation of AGEs results in carbonyl stress, which is characteristic for di…
Detection and Characterization of a Biochemical Signature Associated with Diabetic Nephropathy Using Near-infrared Spectroscopy on Tissue Sections Open
Histological evaluation of renal biopsies is currently the gold standard for acquiring important diagnostic and prognostic information in diabetic nephropathy (DN) patients. Nevertheless, there is an unmet clinical need for new biomarkers …
N-Linked Glycosylation and Near-Infrared Spectroscopy in the Diagnosis of Prostate Cancer Open
Background: Performing a prostate biopsy is the most robust and reliable way to diagnose prostate cancer (PCa), and to determine the disease grading. As little to no biochemical markers for prostate tissue exist, we explored the possibilit…
Analysis of protein glycation in human fingernail clippings with near-infrared (NIR) spectroscopy as an alternative technique for the diagnosis of diabetes mellitus Open
Background: Glycated keratin allows the monitoring of average tissue glucose exposure over previous weeks. In the present study, we wanted to explore if near-infrared (NIR) spectroscopy could be used as a non-invasive diagnostic tool for a…
Quantitative urine test strip reading for leukocyte esterase and hemoglobin peroxidase Open
Background: Recently, urine test strip readers have become available for automated test strip analysis. We explored the possibilities of the Sysmex UC-3500 automated urine chemistry analyzer based on complementary metal oxide semiconductor…