Jonas Protze
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View article: Lactucopicrin: A sesquiterpene lactone with anti-inflammatory activity modulates the crosstalk between NF-kB and AHR pathways
Lactucopicrin: A sesquiterpene lactone with anti-inflammatory activity modulates the crosstalk between NF-kB and AHR pathways Open
Chronic inflammatory diseases, including inflammatory bowel diseases and cardiovascular diseases, share inflammation as a central pathological feature. The transcription factors NF-kB and AHR are key regulators of inflammatory responses, y…
View article: Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions
Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions Open
Synaptic transmission is the predominant form of communication in the brain. It requires functionally specialized molecular machineries constituted by thousands of interacting synaptic proteins. Here, we made use of recent advances in cros…
View article: Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin
Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin Open
Tc toxins deliver toxic enzymes into host cells by a unique injection mechanism. One of these enzymes is the actin ADP-ribosyltransferase TccC3, whose activity leads to the clustering of the cellular cytoskeleton and ultimately cell death.…
View article: Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin
Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin Open
Tc toxins deliver toxic enzymes into host cells by a unique injection mechanism. One of these enzymes is TccC3, an ADP-ribosyltransferase from Photorhabdus luminescens . Once TccC3 is translocated into the target cell, the enzyme ADP-ribos…
View article: Spatial, Quantitative and Functional Deconstruction of Virus and Host Protein Interactions Inside Intact Cytomegalovirus Particles
Spatial, Quantitative and Functional Deconstruction of Virus and Host Protein Interactions Inside Intact Cytomegalovirus Particles Open
Herpesviruses assemble large enveloped particles that are difficult to characterize structurally due to their size, fragility and complex proteome with partially amorphous nature. Here we use cross-linking mass spectrometry and quantitativ…
View article: Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions
Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions Open
Cross-linking mass spectrometry provides a resource for the discovery of novel protein interactions of synaptic protein complexes.
View article: Targeting claudin‐overexpressing thyroid and lung cancer by modified <i>Clostridium perfringens</i> enterotoxin
Targeting claudin‐overexpressing thyroid and lung cancer by modified <i>Clostridium perfringens</i> enterotoxin Open
Clostridium perfringens enterotoxin (CPE) can be used to eliminate carcinoma cells that overexpress on their cell surface CPE receptors – a subset of claudins (e.g., Cldn3 and Cldn4). However, CPE cannot target tumors expressing solely CPE…
View article: Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells
Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells Open
Claudins regulate paracellular permeability in different tissues. The claudin-binding domain of Clostridium perfringens enterotoxin (cCPE) is a known modulator of a claudin subset. However, it does not efficiently bind to claudin-1 (Cldn1)…
View article: Defining a Conformational Consensus Motif in Cotransin-Sensitive Signal Sequences: A Proteomic and Site-Directed Mutagenesis Study
Defining a Conformational Consensus Motif in Cotransin-Sensitive Signal Sequences: A Proteomic and Site-Directed Mutagenesis Study Open
The cyclodepsipeptide cotransin was described to inhibit the biosynthesis of a small subset of proteins by a signal sequence-discriminatory mechanism at the Sec61 protein-conducting channel. However, it was not clear how selective cotransi…