Jonathan A. Roco
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View article: TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function
TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function Open
B-1 cells are innate-like immune cells abundant in serosal cavities with antibodies enriched in bacterial recognition, yet their existence in humans has been controversial 1–3 . The CD5 + B-1a subset expresses anti-inflammatory molecules i…
View article: Computational estimation of clonal diversity in autoimmunity
Computational estimation of clonal diversity in autoimmunity Open
Diversity is the cornerstone of the adaptive immune system, crucial for its effectiveness against constantly evolving pathogens that pose threats to higher vertebrates. Accurately measuring and interpreting this diversity presents challeng…
View article: The transcription factors TCF1 and LEF1 drive B-1a cell development, self-renewal, and regulatory function.
The transcription factors TCF1 and LEF1 drive B-1a cell development, self-renewal, and regulatory function. Open
B-1 cells are abundant in peritoneal and pleural cavities and produce natural and microbial-induced IgM and IgA1–4.CD5+ B-1 cells known as “B-1a” represent the largest source of B cell-derived IL-105,6, an important regulator of inflammati…
View article: ZEB2 regulates the development of CD11c+ atypical B cells
ZEB2 regulates the development of CD11c+ atypical B cells Open
CD11c + atypical B cells (ABC) are an alternative memory B cell lineage identified both in normal immune responses as well as pathogenic responses in autoimmunity. While it is clear that ABCs have a distinct transcriptional program, the fa…
View article: Extrafollicular Plasmablasts Present in the Acute Phase of Infections Express High Levels of PD-L1 and Are Able to Limit T Cell Response
Extrafollicular Plasmablasts Present in the Acute Phase of Infections Express High Levels of PD-L1 and Are Able to Limit T Cell Response Open
During infections with protozoan parasites or some viruses, T cell immunosuppression is generated simultaneously with a high B cell activation. It has been described that, as well as producing antibodies, plasmablasts, the differentiation …
View article: Regulatory roles of IL-10–producing human follicular T cells
Regulatory roles of IL-10–producing human follicular T cells Open
Mucosal lymphoid tissues such as human tonsil are colonized by bacteria and exposed to ingested and inhaled antigens, requiring tight regulation of immune responses. Antibody responses are regulated by follicular helper T (TFH) cells and F…