Jonathan A. Villareal
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View article: Brain Region-Specific Accumulation of Amyloidosis-Associated Proteins in Postmortem Brain Tissues of Alzheimer’s Disease Patients
Brain Region-Specific Accumulation of Amyloidosis-Associated Proteins in Postmortem Brain Tissues of Alzheimer’s Disease Patients Open
View article: Brain Region-specific Accumulation of Amyloidosis-associated Proteins in Postmortem Brain Tissues of Alzheimer’s Disease Patients
Brain Region-specific Accumulation of Amyloidosis-associated Proteins in Postmortem Brain Tissues of Alzheimer’s Disease Patients Open
Numerous extracellular matrix (ECM) proteins, referred to as the matrisome, are increased in Alzheimer’s disease (AD). We recently demonstrated that many of these proteins colocalize with Aβ plaques and cerebral amyloid angiopathy (CAA), a…
View article: Preferential clustering of microglia and astrocytes around neuritic plaques during progression of Alzheimer's disease neuropathological changes
Preferential clustering of microglia and astrocytes around neuritic plaques during progression of Alzheimer's disease neuropathological changes Open
Neuroinflammation plays an important role in the pathological cascade of Alzheimer's disease (AD) along with aggregation of extracellular amyloid‐β (Aβ) plaques and intracellular aggregates of tau protein. In animal models of amyloidosis, …
View article: Impact of severe systemic infections on neuroimmune interactions in neurodegenerative diseases
Impact of severe systemic infections on neuroimmune interactions in neurodegenerative diseases Open
Background Severe systemic infections can trigger cognitive decline, but the underlying mechanisms and their impact on the manifestation and progression of Alzheimer’s disease and other neurodegenerative diseases are poorly understood. The…
View article: Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infection
Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infection Open
Growing evidence has implicated systemic infection as a significant risk factor for the development and advancement of Alzheimer’s disease (AD). With the emergence of SARS-CoV-2 (COVID-19) and the resultant pandemic, many individuals from …
View article: Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infection
Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infection Open
Growing evidence has implicated systemic infection as a significant risk factor for the development and advancement of Alzheimer’s disease (AD). With the emergence of SARS-CoV-2 (COVID-19) and the resultant pandemic, many individuals from …
View article: Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies
Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies Open
The disease-specific accumulation of pathological proteins has long been the major focus of research in neurodegenerative diseases (ND), including Alzheimer’s disease (AD) and related dementias (RD), but the recent identification of a mult…
View article: Transformation of non-neuritic into neuritic plaques during AD progression drives cortical spread of tau pathology via regenerative failure
Transformation of non-neuritic into neuritic plaques during AD progression drives cortical spread of tau pathology via regenerative failure Open