Jonathan Ark
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View article: In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313 Open
Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells in vivo using an evolved adeno-associated virus (AAV) capsid named Ark313. Delivery of a…
View article: An evolved AAV variant enables efficient genetic engineering of murine T cells
An evolved AAV variant enables efficient genetic engineering of murine T cells Open
Precise targeting of large transgenes to T cells using homology-directed repair has been transformative for adoptive cell therapies and T cell biology. Delivery of DNA templates via adeno-associated virus (AAV) has greatly improved knockin…
View article: Receptor Switching in Newly Evolved Adeno-associated Viruses
Receptor Switching in Newly Evolved Adeno-associated Viruses Open
Understanding how viruses interact with host cells through cell surface receptors is central to discovery and development of antiviral therapeutics, vaccines, and gene transfer vectors. Here, we demonstrate that distinct epitopes on the su…
View article: The Golgi Calcium ATPase Pump Plays an Essential Role in Adeno-associated Virus Trafficking and Transduction
The Golgi Calcium ATPase Pump Plays an Essential Role in Adeno-associated Virus Trafficking and Transduction Open
Adeno-associated viruses (AAVs) have proven to be effective gene transfer vectors. However, our understanding of how the host cell environment influences AAV transduction is still evolving. In the present study, we investigated the role of…