Jonathan Ashmore
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View article: A framework for developing generic implant safety procedures for scanning patients with medical implants and devices in MRI
A framework for developing generic implant safety procedures for scanning patients with medical implants and devices in MRI Open
UK guidelines for MR safety recommend that MRI departments refer to the implant manufacturer for advice regarding the MRI safety of scanning patients with an implantable medical device prior to scanning. This process of assuring safety can…
View article: Two operating modes for outer hair cells and implications for cochlear tuning
Two operating modes for outer hair cells and implications for cochlear tuning Open
The role of cochlear outer hair cells (OHCs) in mammal hearing is compromised by the ‘RC time constant problem’. The issue arises because if the cells are to operate at high acoustic frequencies conventional voltage driven ‘electromotility…
View article: Application of synthetic data in the training of artificial intelligence for automated quality assurance in magnetic resonance imaging
Application of synthetic data in the training of artificial intelligence for automated quality assurance in magnetic resonance imaging Open
Background Magnetic resonance imaging scanner faults can be missed during routine quality assurance (QA) if they are subtle, intermittent, or the test being performed is insensitive to the type of fault. Coil element malfunction is a commo…
View article: Joint British Society consensus recommendations for magnetic resonance imaging for patients with cardiac implantable electronic devices
Joint British Society consensus recommendations for magnetic resonance imaging for patients with cardiac implantable electronic devices Open
Magnetic Resonance Imaging (MRI) is increasingly a fundamental component of the diagnostic pathway across a range of conditions. Historically, the presence of a cardiac implantable electronic device (CIED) has been a contraindication for M…
View article: On Various Investigations of the Organ of Corti, from the Effects of Quinine and Quinidine on the Electrical Signature of Outer Hair Cells, to a Method to Prevent Cisplatin Ototoxicity and a New Theory of the Physiological Basis of Electromotility, and the X-Ray Crystalography of Prestin
On Various Investigations of the Organ of Corti, from the Effects of Quinine and Quinidine on the Electrical Signature of Outer Hair Cells, to a Method to Prevent Cisplatin Ototoxicity and a New Theory of the Physiological Basis of Electromotility, and the X-Ray Crystalography of Prestin Open
Jorge Enrique Delgado-Hachmeister, M.D., M.P.H, M.Sc., Ph.D. 1,2, Cindy Shope 5, Daniel Chelius 3, M.D., John S. Oghalai 4, M.D., Raye L. Alford, Ph.D. 5, Bobby R. Alford† 5, M.D., Brenda Farrell, Ph.D 5, Lucy Handscomb, Ph.D. 2, Jonatha…
View article: On Various Investigations of the Organ of Corti, from the Effects of Quinine and Quinidine on the Electrical Signature of Outer Hair Cells, to a Method to Prevent Cisplatin Ototoxicity and a New Theory of the Physiological Basis of Electromotility, and the X-Ray Crystalography of Prestin
On Various Investigations of the Organ of Corti, from the Effects of Quinine and Quinidine on the Electrical Signature of Outer Hair Cells, to a Method to Prevent Cisplatin Ototoxicity and a New Theory of the Physiological Basis of Electromotility, and the X-Ray Crystalography of Prestin Open
Jorge Enrique Delgado-Hachmeister, M.D., M.P.H, M.Sc., Ph.D. 1,2, Cindy Shope 5, Daniel Chelius 3, M.D., John S. Oghalai 4, M.D., Raye L. Alford, Ph.D. 5, Bobby R. Alford† 5, M.D., Brenda Farrell, Ph.D 5, Lucy Handscomb, Ph.D. 2, Jonatha…
View article: On Various Investigations of the Organ of Corti, from the Effects of Quinine and Quinidine on the Electrical Signature of Outer Hair Cells, to a Method to Prevent Cisplatin Ototoxicity and a New Theory of the Physiological Basis of Electromotility, and the X-Ray Crystalography of Prestin
On Various Investigations of the Organ of Corti, from the Effects of Quinine and Quinidine on the Electrical Signature of Outer Hair Cells, to a Method to Prevent Cisplatin Ototoxicity and a New Theory of the Physiological Basis of Electromotility, and the X-Ray Crystalography of Prestin Open
Jorge Enrique Delgado-Hachmeister, M.D., M.P.H, M.Sc., Ph.D. 1,2, Cindy Shope 5, Daniel Chelius 3, M.D., John S. Oghalai 4, M.D., Raye L. Alford, Ph.D. 5, Bobby R. Alford† 5, M.D., Brenda Farrell, Ph.D 5, Lucy Handscomb, Ph.D. 2, Jonatha…
View article: On Various Investigations of the Organ of Corti, from the Effects of Quinine and Quinidine on the Electrical Signature of Outer Hair Cells, to a Method to Prevent Cisplatin Ototoxicity and a New Theory of the Physiological Basis of Electromotility, and the X-Ray Crystalography of Prestin
On Various Investigations of the Organ of Corti, from the Effects of Quinine and Quinidine on the Electrical Signature of Outer Hair Cells, to a Method to Prevent Cisplatin Ototoxicity and a New Theory of the Physiological Basis of Electromotility, and the X-Ray Crystalography of Prestin Open
Jorge Enrique Delgado-Hachmeister, M.D., M.P.H, M.Sc., Ph.D. 1,2, Cindy Shope 5, Daniel Chelius 3, M.D., John S. Oghalai 4, M.D., Raye L. Alford, Ph.D. 5, Bobby R. Alford† 5, M.D., Brenda Farrell, Ph.D 5, Lucy Handscomb, Ph.D. 2, Jonatha…
View article: Origin of eukaryotes: What can be learned from the first successfully isolated Asgard archaeon
Origin of eukaryotes: What can be learned from the first successfully isolated Asgard archaeon Open
The origin of cellular complexity characterizing eukaryotic cells remains a central unresolved issue in the study of diversification of cellular life on Earth. The isolation by Imachi et al.1 of a member of the Asgard archaea2 – a contempo…
View article: A resolution record for cryoEM
A resolution record for cryoEM Open
Cryo electron microscopy (cryoEM) is a fast-growing technique for structure determination. Two recent papers report the first atomic resolution structure of a protein obtained by averaging images of frozen-hydrated biomolecules. They both …
View article: Listening in to the Cell
Listening in to the Cell Open
Looking up one day from his copy of Pakistan News in his office at Imperial College London, Abdus Salam asked me: ''Well what are you doing after your PhD?''I replied that I hadn't even thought about
View article: Implementation of clinical tractography for pre-surgical planning of space occupying lesions: An investigation of common acquisition and post-processing methods compared to dissection studies
Implementation of clinical tractography for pre-surgical planning of space occupying lesions: An investigation of common acquisition and post-processing methods compared to dissection studies Open
Advanced post processing techniques such as CSD with probabilistic tractography are vital for pre-surgical planning. However, overall accuracy relative to dissection studies remains limited.
View article: Implementation of clinically relevant and robust fMRI-based language lateralization: Choosing the laterality index calculation method
Implementation of clinically relevant and robust fMRI-based language lateralization: Choosing the laterality index calculation method Open
The assessment of language lateralization has become widely used when planning neurosurgery close to language areas, due to individual specificities and potential influence of brain pathology. Functional magnetic resonance imaging (fMRI) a…
View article: Macromolecular and electrical coupling between inner hair cells in the rodent cochlea
Macromolecular and electrical coupling between inner hair cells in the rodent cochlea Open
Inner hair cells (IHCs) are the primary receptors for hearing. They are housed in the cochlea and convey sound information to the brain via synapses with the auditory nerve. IHCs have been thought to be electrically and metabolically indep…
View article: A maturing view of cochlear calcium
A maturing view of cochlear calcium Open
Charles Darwin was exercised to explain how a structure as complex as the human eye could have evolved. Had he been conversant with the mammalian cochlea, in his time just starting to be examined by the microscope, he would have had an eve…
View article: Wnts control membrane potential in mammalian cancer cells
Wnts control membrane potential in mammalian cancer cells Open
Key points Wnt ligands belonging to both canonical and non‐canonical Wnt pathways regulate membrane potential signifying a very early event in the signal transduction. Wnts activate K + currents by elevating intracellular Ca 2+ and trigger…
View article: Intercellular Ca<sup>2+</sup> signalling in the adult mouse cochlea
Intercellular Ca<sup>2+</sup> signalling in the adult mouse cochlea Open
Key points Intercellular Ca 2+ waves are increases in cytoplasmic Ca 2+ levels that propagate between cells. Periodic Ca 2+ waves have been linked to gene regulation and are thought to play a crucial role in the development of our hearing …
View article: Outer Hair Cells and Electromotility
Outer Hair Cells and Electromotility Open
Outer hair cells (OHCs) of the mammalian cochlea behave like actuators: they feed energy into the cochlear partition and determine the overall mechanics of hearing. They do this by generating voltage-dependent axial forces. The resulting c…
View article: The neuroscience of hearing or how to do a hard job with soft components
The neuroscience of hearing or how to do a hard job with soft components Open
The inner ear is a small and relatively inaccessible structure. The use of multiple biophysical recording techniques from the late 1970s onwards, combined with molecular genetics to identify genes critically involved in cochlear developmen…
View article: Outcome study of the pipeline embolization device for treatment of intracranial aneurysms at a single UK institution
Outcome study of the pipeline embolization device for treatment of intracranial aneurysms at a single UK institution Open
Highly selected aneurysms treated with a PED in a UK centre have similar occlusion and complication rates when compared to non-UK studies. Again, it appeared that delayed aneurysm rupture remained a risk for PED treatment in large or giant…
View article: Non-Monotonic Relation between Noise Exposure Severity and Neuronal Hyperactivity in the Auditory Midbrain
Non-Monotonic Relation between Noise Exposure Severity and Neuronal Hyperactivity in the Auditory Midbrain Open
The occurrence of tinnitus can be linked to hearing loss in the majority of cases, but there is nevertheless a large degree of unexplained heterogeneity in the relation between hearing loss and tinnitus. Part of the problem might be that h…
View article: Stretching out the early steps in hearing
Stretching out the early steps in hearing Open
The molecular basis of mechanotransduction is one of the major problems, probably the unsolved problem, in hearing and balance. Sensory hair cells in both the cochlea and the vestibular systems of the inner ear have at one end a bundle of …