Jonathan B. Ashman
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View article: PATH-66. Double identity: molecular heterogeneity between liquid biopsy from the CSF and tissue samples of a multifocal, disseminated High-Grade Astrocytoma with Piloid Features (HGAP) in NF1 patient
PATH-66. Double identity: molecular heterogeneity between liquid biopsy from the CSF and tissue samples of a multifocal, disseminated High-Grade Astrocytoma with Piloid Features (HGAP) in NF1 patient Open
We describe a 46-year-old male with Neurofibromatosis type 1 (NF1) and a previously known parenchymal medullary mass identified in 2022, initially managed with surveillance. In late 2023, he developed a progressive brainstem syndrome promp…
View article: AI in Proton Therapy Treatment Planning: A Review.
AI in Proton Therapy Treatment Planning: A Review. Open
AI is emerging as a key enabler of efficient, consistent, and patient-specific proton therapy treatment planning. Addressing challenges in validation and implementation will be essential for its translation into routine clinical practice.
View article: Simulation‐free workflow for lattice radiation therapy using deep learning predicted synthetic computed tomography: A feasibility study
Simulation‐free workflow for lattice radiation therapy using deep learning predicted synthetic computed tomography: A feasibility study Open
Purpose Lattice radiation therapy (LRT) is a form of spatially fractionated radiation therapy that allows increased total dose delivery aiming for improved treatment response without an increase in toxicities, commonly utilized for palliat…
View article: Diffusion Transformer-based Universal Dose Denoising for Pencil Beam Scanning Proton Therapy.
Diffusion Transformer-based Universal Dose Denoising for Pencil Beam Scanning Proton Therapy. Open
A diffusion transformer-based denoising framework was successfully developed. Although the denoising model was trained using only H&N data, it can accurately and robustly denoise noisy dose maps across different disease sites.
View article: Deep Learning-Based Synthetic CT for Personalized Treatment Modality Selection Between Proton and Photon Therapy in Thoracic Cancer
Deep Learning-Based Synthetic CT for Personalized Treatment Modality Selection Between Proton and Photon Therapy in Thoracic Cancer Open
Objectives: Identifying patients’ advantageous radiotherapy modalities prior to CT simulation is challenging. This study aimed to develop a workflow using deep learning (DL)-predicted synthetic CT (sCT) for treatment modality comparison ba…
View article: Radiation Segmentectomy or Ablative External Beam Radiation Therapy as Initial Treatment for Solitary Hepatocellular Carcinoma: A Multicenter Experience
Radiation Segmentectomy or Ablative External Beam Radiation Therapy as Initial Treatment for Solitary Hepatocellular Carcinoma: A Multicenter Experience Open
RS and EBRT are effective therapies for solitary HCC. Treatment should be determined via multidisciplinary discussion based on individual patient characteristics.
View article: Comprehensive Analysis of Treatment Approaches in Chest Wall Ewing Sarcoma: The Impact of Tumor Volume on Oncologic Outcomes
Comprehensive Analysis of Treatment Approaches in Chest Wall Ewing Sarcoma: The Impact of Tumor Volume on Oncologic Outcomes Open
Outcomes for cwES tumors are highly dependent on tumor size, even with the use of combined modality local therapy. With early follow-up, smaller tumors may be well controlled with either S or RT.
View article: Establishing the minimal clinically important difference of the Brief Fatigue Inventory for brain or CNS cancer patients undergoing radiotherapy
Establishing the minimal clinically important difference of the Brief Fatigue Inventory for brain or CNS cancer patients undergoing radiotherapy Open
Background Minimal clinically important differences (MCIDs) quantify the clinical relevance of quality of life results at the individual patient and group level. The aim of this study was to estimate the MCID for the Brief Fatigue Inventor…
View article: Implementation of the REFLECT Communication Curriculum for Clinical Oncology Graduate Medical Education.
Implementation of the REFLECT Communication Curriculum for Clinical Oncology Graduate Medical Education. Open
Background: Communication and interpersonal skills are essential medical components of oncology patient care. Patients and families rely on physicians for treatment, expertise, guidance, hope, meaning, and compassion throughout a life-thre…
View article: RADT-25. IMPACT OF 18F-DOPA PET ON RADIATION TREATMENT PLANNING FROM PHASE II STUDY OF SHORT COURSE HYPOFRACTIONATED PROTON BEAM THERAPY FOR ELDERLY PATIENTS WITH GLIOBLASTOMA
RADT-25. IMPACT OF 18F-DOPA PET ON RADIATION TREATMENT PLANNING FROM PHASE II STUDY OF SHORT COURSE HYPOFRACTIONATED PROTON BEAM THERAPY FOR ELDERLY PATIENTS WITH GLIOBLASTOMA Open
PURPOSE 18F-DOPA is sensitive/specific for identifying areas of biologically aggressive disease for glioblastoma. We report the impact of 18F-DOPA on radiation treatment planning from a phase II study. METHODS Gross target volume (GTV) was…
View article: Benchmarking a foundation LLM on its ability to re-label structure names in accordance with the AAPM TG-263 report
Benchmarking a foundation LLM on its ability to re-label structure names in accordance with the AAPM TG-263 report Open
Purpose: To introduce the concept of using large language models (LLMs) to re-label structure names in accordance with the American Association of Physicists in Medicine (AAPM) Task Group (TG)-263 standard, and to establish a benchmark for…
View article: Evaluating large language models on a highly-specialized topic, radiation oncology physics
Evaluating large language models on a highly-specialized topic, radiation oncology physics Open
Purpose We present the first study to investigate Large Language Models (LLMs) in answering radiation oncology physics questions. Because popular exams like AP Physics, LSAT, and GRE have large test-taker populations and ample test prepara…
View article: Attitudes and Perception of the REFLECT Communication Curriculum for Clinical Oncology Graduate Medical Education
Attitudes and Perception of the REFLECT Communication Curriculum for Clinical Oncology Graduate Medical Education Open
Communication and interpersonal skills are essential components of oncology patient care. The REFLECT ( R espect, E mpathy, F acilitate Effective Communication, L isten, E licit Information, C ompassion, and T each Others) curriculum is a …
View article: Dosimetric comparison between proton beam therapy, intensity modulated radiation therapy, and 3D conformal therapy for soft tissue extremity sarcoma
Dosimetric comparison between proton beam therapy, intensity modulated radiation therapy, and 3D conformal therapy for soft tissue extremity sarcoma Open
PBT plans for selected patients with eSTS demonstrated improved sparing of circumferential soft tissue and adjacent bone compared to IMRT and 3D-CRT. Further evaluation will determine if this improved dosimetry correlates with reduced toxi…
View article: Evaluating Large Language Models on a Highly-specialized Topic, Radiation Oncology Physics
Evaluating Large Language Models on a Highly-specialized Topic, Radiation Oncology Physics Open
We present the first study to investigate Large Language Models (LLMs) in answering radiation oncology physics questions. Because popular exams like AP Physics, LSAT, and GRE have large test-taker populations and ample test preparation res…
View article: Pragmatic, Prospective Comparative Effectiveness Trial of Carbon Ion Therapy, Surgery, and Proton Therapy for the Management of Pelvic Sarcomas (Soft Tissue/Bone) Involving the Bone: The PROSPER Study Rationale and Design
Pragmatic, Prospective Comparative Effectiveness Trial of Carbon Ion Therapy, Surgery, and Proton Therapy for the Management of Pelvic Sarcomas (Soft Tissue/Bone) Involving the Bone: The PROSPER Study Rationale and Design Open
Surgical treatment of pelvic sarcoma involving the bone is the standard of care but is associated with several sequelae and reduced functional quality of life (QOL). Treatment with photon and proton radiotherapy is associated with relapse.…
View article: Clinical Outcomes of Stereotactic Radiosurgery-Related Radiation Necrosis in Patients with Intracranial Metastasis from Melanoma
Clinical Outcomes of Stereotactic Radiosurgery-Related Radiation Necrosis in Patients with Intracranial Metastasis from Melanoma Open
Background: Radiation necrosis (RN) is a clinically relevant complication of stereotactic radiosurgery (SRS) for intracranial metastasis (ICM) treatments. Radiation necrosis development is variable following SRS. It remains unclear if risk…
View article: Association of circulating markers with cognitive decline after radiation therapy for brain metastasis
Association of circulating markers with cognitive decline after radiation therapy for brain metastasis Open
Background A recent phase III trial (NCT01372774) comparing use of stereotactic radiosurgery [SRS] versus whole-brain radiation therapy [WBRT] after surgical resection of a single brain metastasis revealed that declines in cognitive functi…
View article: Association of Long-term Outcomes With Stereotactic Radiosurgery vs Whole-Brain Radiotherapy for Resected Brain Metastasis
Association of Long-term Outcomes With Stereotactic Radiosurgery vs Whole-Brain Radiotherapy for Resected Brain Metastasis Open
Importance Long-term outcomes of radiotherapy are important in understanding the risks and benefits of therapies for patients with brain metastases. Objective To determine how the use of postoperative whole-brain radiotherapy (WBRT) or ste…
View article: Excellent clinical outcomes can be achieved with neoadjuvant chemoradiation and orthotopic liver transplantation for unresectable cholangiocarcinoma: support for the need of an international transplant protocol
Excellent clinical outcomes can be achieved with neoadjuvant chemoradiation and orthotopic liver transplantation for unresectable cholangiocarcinoma: support for the need of an international transplant protocol Open
Excellent clinical outcomes can be achieved with neoadjuvant chemoradiation and orthotopic liver transplantation for unresectable cholangiocarcinoma: support for the need of an international transplant protocol
View article: Early Experience Using Proton Beam Therapy for Extremity Soft Tissue Sarcoma: A Multicenter Study
Early Experience Using Proton Beam Therapy for Extremity Soft Tissue Sarcoma: A Multicenter Study Open
PBT for well selected eSTS cases demonstrated excellent local control and similar acute wound complication rate comparable to historic controls. Long-term follow-up and further dosimetric analyses will provide further insight into potentia…
View article: Clinical outcomes for hilar and extrahepatic cholangiocarcinoma with adjuvant, definitive, or liver transplant-based neoadjuvant chemoradiotherapy strategies: a single-center experience
Clinical outcomes for hilar and extrahepatic cholangiocarcinoma with adjuvant, definitive, or liver transplant-based neoadjuvant chemoradiotherapy strategies: a single-center experience Open
Outcomes for patients with extrahepatic CCA were superior for those who underwent nCRT/orthotopic liver transplant or postsurgical aCRT than for patients treated with dCRT. The excellent outcomes after nCRT/orthotopic liver transplant prov…