Explanipedia

Trends in immunomodulatory therapy for the treatment of chronic uveitis in the United States Open

Jonathan B. Lin, Mario Cale, Thomas A. Albini · 2025

Risk of Glaucoma after Pars Plana Vitrectomy in a Large Federated Health Record Network Open

Jonathan B. Lin, Karen M. Wai, Prithvi Mruthyunjaya, Ehsan Rahimy · 2025

Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma Open

Jonathan B. Lin, Hani El Helwe, Henisk Falah, Bruno L. Hammerschlag, Stephanie A. Schultz , et al. · 2025

NfL levels in AH may be a molecular marker of retinal ganglion cell health in glaucoma; in contrast, serum NfL has limited utility for monitoring glaucomatous neurodegeneration.

Resolution of subretinal fluid in intractable central serous chorioretinopathy with high-dose intravitreal aflibercept Open

Jonathan B. Lin, Loh-Shan Leung · 2025

Proliferative Vitreoretinopathy: Pathophysiology and Therapeutic Approaches Open

Jonathan B. Lin, Frances Wu, Leo A. Kim · 2024

Proliferative vitreoretinopathy (PVR) is a complication of retinal detachment (RD) that is characterized by the development of retinal stiffness and contractile membranes on the surface or underside of the retina. It can occur in primary R…

Comparing Outcomes of 45 Xen Implantation Ab Interno With Closed Conjunctiva to Ab Externo With Open Conjunctiva Approaches Open

Hani El Helwe, Zoë Ingram, Cameron Neeson, Henisk Falah, J Trzciński , et al. · 2023

Précis: Ab externo with open conjunctiva placement may lead to improved gelatin stent (XEN Gel Stent; Allergan) success rate compared with ab interno with closed conjunctiva because it conferred more favorable intraocular pressure (IOP) an…

Neurofilament Light Chain in Aqueous Humor as a Marker of Neurodegeneration in Glaucoma Open

Jonathan B. Lin, Kristen Pitts, Hani El Helwe, Cameron Neeson, Nathan Hall , et al. · 2023

Our findings suggest that AH NfL may have clinical utility as a marker of glaucomatous neurodegeneration.

Systemic Dyslipidemia in Age-related Macular Degeneration Open

Brandon Li, Deborah Goss, Joan W. Miller, Jonathan B. Lin, Demetrios G. Vavvas · 2023

Neurodegeneration Markers Galectin-3 and Apolipoprotein E Are Elevated in the Aqueous Humor of Eyes With Glaucoma Open

Kristen Pitts, Cameron Neeson, Nathan Hall, Jonathan B. Lin, Henisk K. Falah , et al. · 2022

Gal-3 and APOE in AH may inform clinical decision-making as quantifiable readouts of microglial activation in eyes with glaucoma.

Neuroprotection for Age-Related Macular Degeneration Open

Jonathan B. Lin, Yusuke Murakami, Joan W. Miller, Demetrios G. Vavvas · 2022

Age-related macular degeneration (AMD) is a leading cause of blindness worldwide. Early to intermediate AMD is characterized by the accumulation of lipid- and protein-rich drusen. Late stages of the disease are characterized by the develop…

Systemic Complement Activation Profiles in Nonexudative Age-Related Macular Degeneration: A Meta-Analysis Open

Jonathan B. Lin, Stylianos Serghiou, Joan W. Miller, Demetrios G. Vavvas · 2022

Although complement inhibition has emerged as a possible therapeutic strategy for age-related macular degeneration (AMD), there is not a clear consensus regarding what aspects of the complement pathway are dysregulated in AMD and when this…

“Complement-ary” Therapies for Age-Related Macular Degeneration Open

Jonathan B. Lin, Rajendra S. Apte · 2022

Although anti-VEGF agents have transformed our ability to treat patients with advanced exudative age-related macular degeneration (AMD), there are currently no approved treatments to slow photoreceptor and retinal pigment epithelium degene…

Systemic Complement Activation Profiles in Nonexudative Age-Related Macular Degeneration Open

Jonathan B. Lin, Stylianos Serghiou, Joan W. Miller, Demetrios G. Vavvas · 2022

Evidence suggests that systemic complement overactivation is a feature of early or intermediate and advanced nonexudative AMD. However, given significant heterogeneity, these findings are not conclusive and warrant further investigation.

Dyslipidemia in age-related macular degeneration Open

Jonathan B. Lin, Omar Halawa, Deeba Husain, Joan W. Miller, Demetrios G. Vavvas · 2022

Complement Inhibition for Geographic Atrophy: A Tempting Target with Mixed Results Open

Jonathan B. Lin, Omar Halawa, Joan W. Miller, Demetrios G. Vavvas · 2021

Age-related macular degeneration (AMD) is a leading cause of blindness in older adults. One of the strongest genetic risk factors for AMD is a complement factor H (CFH) gene polymorphism characterized by a tyrosine-histidine change at amin…

A Review of Completed and Ongoing Complement Inhibitor Trials for Geographic Atrophy Secondary to Age-Related Macular Degeneration Open

Omar Halawa, Jonathan B. Lin, Joan W. Miller, Demetrios G. Vavvas · 2021

Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among older adults in the Western world. While therapies exist for patients with exudative AMD, there are currently no approved therapies for non-exudative…

Longitudinal Growth Differentiation Factor 15 (GDF15) and Long-term Intraocular Pressure Fluctuation in Glaucoma: A Pilot Study Open

Jonathan B. Lin, Arsham Sheybani, Andrea Santeford, Rajendra S. Apte · 2021

Purpose: Growth Differentiation Factor 15 (GDF15) was previously identified as a molecular marker of retinal ganglion cell stress in rodent models of glaucoma and was elevated in the aqueous humor (AH) of patients with primary open-angle g…

Increased Aqueous Humor GDF15 Is Associated with Worse Visual Field Loss in Pseudoexfoliative Glaucoma Patients Open

Jonathan B. Lin, Arsham Sheybani, Andrea Santeford, Alicia María, Rajendra S. Apte · 2020

This study provides proof of concept that GDF15, a molecular marker of retinal ganglion stress that was initially identified in rodent models, may have clinical utility as a measure of glaucoma severity not only in POAG but also in PXG.

Understanding the Molecular Pathogenesis of Retinal Neurodegeneration Open

Jonathan B. Lin · 2020

Anterior Chamber Angles after Intravitreal Injections for Macular Degeneration Open

Bliss E. O’Bryhim, Jonathan B. Lin, Kisha Piggott, P. Kumar Rao, Rajendra S. Apte · 2020

Incidence of Glaucoma or Ocular Hypertension After Repeated Anti-Vascular Endothelial Growth Factor Injections for Macular Degeneration Open

Jeremy B. Wingard, Darcie A. P. Delzell, Nathan V. Houlihan, Jonathan B. Lin, Jon P. Gieser · 2019

Our results show a significant risk for glaucoma or OHT development in patients undergoing repeated treatments with intravitreal anti-VEGF injections for AMD, establishing the first reliable connection between disease development and a per…

Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice Open

Mitsukuni Yoshida, Akiko Satoh, Jonathan B. Lin, Kathryn F. Mills, Yo Sasaki , et al. · 2019

Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes Open

Jonathan B. Lin, Joseph B. Lin, Howard C. Chen, Teresa Chen, Rajendra S. Apte · 2019

Visualizing the Heterogeneity of Retinal Microglia Open

Jonathan B. Lin, Rajendra S. Apte · 2019

Late detachment of Descemet's membrane after penetrating keratoplasty for pellucid marginal degeneration Open

Jonathan B. Lin, Salima Hassanaly, Robert A. Hyde, Jennifer Brown, Dan Yoon , et al. · 2018

Serial circulating tumor DNA analysis for detection of residual disease, assessment of adjuvant therapy efficacy and for early recurrence detection in colorectal cancer Open

Thomas Reinert, Tenna Vesterman Henriksen, Mads H. Rasmussen, Himanshu Sethi, Raheleh Salari , et al. · 2018

Background: Early detection of disease recurrence has been shown to improve survival in patients with colorectal cancer (CRC). Previous studies have analyzed circulating tumor DNA (ctDNA) to monitor tumor burden in CRC using small gene pan…

Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss Open

Norimitsu Ban, Tae Jun Lee, Abdoulaye Sène, Mayur Choudhary, Michael Lekwuwa , et al. · 2018

Advanced age-related macular degeneration (AMD), the leading cause of blindness among people over 50 years of age, is characterized by atrophic neurodegeneration or pathologic angiogenesis. Early AMD is characterized by extracellular chole…

Photoreceptor Cholesterol Metabolism Regulates Age-Related Retinal Neurodegeneration Open

Norimitsu Ban, Abdoulaye Sène, Tae Jun Lee, Zhenyu Dong, Andrea Santeford , et al. · 2018

Role of macrophage microRNA-150 in age-related macular degeneration Open

Jonathan B. Lin, Harsh Moolani, Abdoulaye Sène, Rohini Sidhu, Joseph B. Lin , et al. · 2018

Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration Open

Norimitsu Ban, Tae Jun Lee, Abdoulaye Sène, Zhenyu Dong, Andrea Santeford , et al. · 2018

Photoreceptors have high intrinsic metabolic demand and are exquisitely sensitive to metabolic perturbation. In addition, they shed a large portion of their outer segment lipid membranes in a circadian manner, increasing the metabolic burd…

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