Jonathan B. Orens
YOU?
Author Swipe
View article: Sustained Molecular Allograft Injury After Episodes of Acute Rejection and Organizing Pneumonia Increases the Risk of Lung Allograft Failure
Sustained Molecular Allograft Injury After Episodes of Acute Rejection and Organizing Pneumonia Increases the Risk of Lung Allograft Failure Open
Background. Despite treatment of major risk factors such as acute rejection (AR) and organizing pneumonia (OP) in lung transplant recipients, chronic lung allograft dysfunction (CLAD) still develops at high rates, suggesting that tradition…
View article: Impact of donor specific antibodies on longitudinal lung function and baseline lung allograft dysfunction
Impact of donor specific antibodies on longitudinal lung function and baseline lung allograft dysfunction Open
Our study demonstrates that DSA development significantly impairs post-transplant lung function and increases the risk of BLAD even in the absence of clinical AMR. These findings suggest that DSA may serve as a biomarker of BLAD, and could…
View article: Candida dubliniensis breast implant infection in a lung transplant recipient
Candida dubliniensis breast implant infection in a lung transplant recipient Open
View article: Baseline Lung Allograft Dysfunction After Bilateral Lung Transplantation Is Associated With an Increased Risk of Death: Results From a Multicenter Cohort Study
Baseline Lung Allograft Dysfunction After Bilateral Lung Transplantation Is Associated With an Increased Risk of Death: Results From a Multicenter Cohort Study Open
Background. A prior single-center, retrospective cohort study identified baseline lung allograft dysfunction (BLAD) as a risk factor for death in bilateral lung transplant recipients. In this multicenter prospective cohort study, we test t…
View article: Cell-Free DNA Maps Tissue Injury and Correlates with Disease Severity in Lung Transplant Candidates
Cell-Free DNA Maps Tissue Injury and Correlates with Disease Severity in Lung Transplant Candidates Open
Rationale: Plasma cell-free DNA levels correlate with disease severity in many conditions. Pretransplant cell-free DNA may risk stratify lung transplant candidates for post-transplant complications. Objectives: To evaluate if…
View article: Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates
Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates Open
View article: The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation
The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation Open
Rationale: Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation. Prior studies implicated proxy-defined donor smoking as a risk factor for PGD and mortality. Objectives:…
View article: Contemporary trends in PGD incidence, outcomes, and therapies
Contemporary trends in PGD incidence, outcomes, and therapies Open
View article: Donor derived cell free DNA% is elevated with pathogens that are risk factors for acute and chronic lung allograft injury
Donor derived cell free DNA% is elevated with pathogens that are risk factors for acute and chronic lung allograft injury Open
View article: Donor-derived cell-free DNA accurately detects acute rejection in lung transplant patients, a multicenter cohort study
Donor-derived cell-free DNA accurately detects acute rejection in lung transplant patients, a multicenter cohort study Open
View article: Rising PGD Incidence Parallels Increased Recipient Disease Severity
Rising PGD Incidence Parallels Increased Recipient Disease Severity Open
View article: Cell-Free DNA to Monitor Immunosuppression Adequacy in Lung Transplantation
Cell-Free DNA to Monitor Immunosuppression Adequacy in Lung Transplantation Open
View article: Racial Differences in Immunosuppression and Lung Transplant Outcomes
Racial Differences in Immunosuppression and Lung Transplant Outcomes Open
View article: Predicting PGD after Lung Transplantation
Predicting PGD after Lung Transplantation Open
View article: Impact of AMR Treatment: Responders vs Non-Responders Characteristics
Impact of AMR Treatment: Responders vs Non-Responders Characteristics Open
View article: Use of donor-derived-cell-free DNA as a marker of early allograft injury in primary graft dysfunction (PGD) to predict the risk of chronic lung allograft dysfunction (CLAD)
Use of donor-derived-cell-free DNA as a marker of early allograft injury in primary graft dysfunction (PGD) to predict the risk of chronic lung allograft dysfunction (CLAD) Open
View article: Risk of primary graft dysfunction following lung transplantation in selected adults with connective tissue disease-associated interstitial lung disease
Risk of primary graft dysfunction following lung transplantation in selected adults with connective tissue disease-associated interstitial lung disease Open
View article: Bronchoscopic Transbronchial Biopsies for Assessment of Lung Allograft Rejection: Factors That Impact Specimen Adequacy
Bronchoscopic Transbronchial Biopsies for Assessment of Lung Allograft Rejection: Factors That Impact Specimen Adequacy Open
View article: Donor-derived cell-free DNA predicts allograft failure and mortality after lung transplantation
Donor-derived cell-free DNA predicts allograft failure and mortality after lung transplantation Open
View article: Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury
Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury Open
Primary graft dysfunction (PGD) is acute lung injury within 72 hours of lung transplantation. We hypothesized that cell-free hemoglobin (CFH) contributes to PGD by increasing lung microvascular permeability and tested this in patients, ex …
View article: Impaired Renal Function Should Not Be a Barrier to Transplantation in Patients With Cystic Fibrosis
Impaired Renal Function Should Not Be a Barrier to Transplantation in Patients With Cystic Fibrosis Open
View article: Clinical Risk Factors and Prognostic Model for Primary Graft Dysfunction after Lung Transplantation in Patients with Pulmonary Hypertension
Clinical Risk Factors and Prognostic Model for Primary Graft Dysfunction after Lung Transplantation in Patients with Pulmonary Hypertension Open
Several recipient, donor, and operative characteristics were associated with severe primary graft dysfunction in patients with pulmonary hypertension, including several risk factors not identified in the overall transplant population. A pr…
View article: Splenic Irradiation for the Treatment of Severe Antibody-Mediated Rejection
Splenic Irradiation for the Treatment of Severe Antibody-Mediated Rejection Open
Patients requiring desensitization prior to renal transplantation are at risk for developing severe antibody-mediated rejection (AMR) refractory to treatment with plasmapheresis and intravenous immunoglobulin (PP/IVIg). We have previously …
View article: WITHDRAWN
WITHDRAWN Open
View article: Soluble CD14 and LBP as Markers for Primary Graft Dysfunction
Soluble CD14 and LBP as Markers for Primary Graft Dysfunction Open
View article: Redefining Primary Graft Dysfunction after Lung Transplantation
Redefining Primary Graft Dysfunction after Lung Transplantation Open
View article: Plasma RIP3 Is Decreased in PGD after Lung Transplantation
Plasma RIP3 Is Decreased in PGD after Lung Transplantation Open
View article: The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia
The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia Open
View article: IL-12–Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control
IL-12–Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control Open
CMV remains an important opportunistic pathogen in solid organ and hematopoietic cell transplantation, particularly in lung transplant recipients (LTRs). LTRs mismatched for CMV (donor+/recipient−; D+R−) are at high risk for active CMV inf…
View article: Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation
Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation Open