Jonathan B. Overdevest
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View article: Performance on a novel odor recognition memory test preferentially associates with specific cognitive measures and psychophysical characteristics
Performance on a novel odor recognition memory test preferentially associates with specific cognitive measures and psychophysical characteristics Open
Background Olfaction and memory are each independently disrupted in Alzheimer's disease (AD) early in the clinical course. Odor memory measures combining these two systems may be more capable of distinguishing these disorders than measure …
View article: Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation
Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation Open
Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease of the sinonasal cavity affecting millions worldwide. Its complex pathophysiology remains poorly understood, with emerging evidence implicating interactions between dive…
View article: Abridging the 22‐Item Sino‐Nasal Outcome Test (SNOT‐22) in People With Cystic Fibrosis: Limiting Survey Burden
Abridging the 22‐Item Sino‐Nasal Outcome Test (SNOT‐22) in People With Cystic Fibrosis: Limiting Survey Burden Open
Chronic rhinosinusitis (CRS) affects quality-of-life (QoL) in people with cystic fibrosis (PwCF), despite the reduction in symptoms and symptom severity associated with cystic fibrosis transmembrane conductance regulator (CFTR) modulators …
View article: Endoscopic Pituitary Surgery in High‐Resource Settings Versus a Public Hospital in Ghana
Endoscopic Pituitary Surgery in High‐Resource Settings Versus a Public Hospital in Ghana Open
Objective The evidence supporting endoscopic transsphenoidal pituitary adenoma resection (TSPR) is predominantly from skull base centers in high‐resource settings (HRSs). This study is the first comparative analysis of TSPR performed at a …
View article: Exploration of Olfaction and ChiPSO in Pediatric Cystic Fibrosis
Exploration of Olfaction and ChiPSO in Pediatric Cystic Fibrosis Open
Background/Objectives: Olfactory dysfunction (OD) is a common symptom among people with cystic fibrosis (PwCF) and contributes to environmental safety concerns, nutritional challenges, and an overall diminished quality of life. OD is perce…
View article: Olfaction, Eating Preference, and Quality of Life in Cystic Fibrosis Chronic Rhinosinusitis
Olfaction, Eating Preference, and Quality of Life in Cystic Fibrosis Chronic Rhinosinusitis Open
Objectives Olfactory dysfunction (OD) is common among people with cystic fibrosis (PwCF) and chronic rhinosinusitis (CRS). OD is associated with impaired quality of life (QOL) and dietary alterations in certain non‐CF populations. This stu…
View article: Interrelatedness of Neurocognitive Domain Functioning Between Unprompted and Prompted Identification Testing With Psychophysical Olfactory Evaluation in a Post‐COVID‐19 Cohort
Interrelatedness of Neurocognitive Domain Functioning Between Unprompted and Prompted Identification Testing With Psychophysical Olfactory Evaluation in a Post‐COVID‐19 Cohort Open
Objective Assessment of olfactory function with psychophysical testing requires cognitive demand to correctly pair test odors with remembered scents. Individuals suffering from long‐Corona Virus Disease 2019 (long‐COVID‐19) may develop a d…
View article: Depression, Anxiety, and Neuropsychiatric Symptom Burden in a Longitudinal Cohort with Persistent Psychophysical Post-COVID Olfactory Dysfunction
Depression, Anxiety, and Neuropsychiatric Symptom Burden in a Longitudinal Cohort with Persistent Psychophysical Post-COVID Olfactory Dysfunction Open
Background/Objectives: Olfactory dysfunction (OD) is associated with a variety of neurologic deficits and impacts socialization decisions, mood, and overall quality of life. As a common symptom comprising the long COVID condition, persiste…
View article: A breath of fresh air: a pilot flipped classroom approach to airway management skills training
A breath of fresh air: a pilot flipped classroom approach to airway management skills training Open
Objectives While flipped classroom instruction has repeatedly shown efficacy in undergraduate medical education, evidence for its utility in procedural domains remains sparse. This holds particular significance for surgical subspecialties …
View article: Subjective Versus Psychophysical Measures of Chemosensory Alterations Following COVID-19
Subjective Versus Psychophysical Measures of Chemosensory Alterations Following COVID-19 Open
Introduction: Olfactory dysfunction is a common symptom of COVID-19. However, subjective perception of olfactory function does not always correlate well with more objective measures. This study seeks to clarify associations between subject…
View article: Recovery rates of persistent post‐COVID‐19 olfactory dysfunction using psychophysical assessment: A longitudinal cohort study
Recovery rates of persistent post‐COVID‐19 olfactory dysfunction using psychophysical assessment: A longitudinal cohort study Open
Objectives Persistent olfactory dysfunction (OD) following loss of smell associated with SARS‐CoV‐2 infection is a major feature of long COVID. Perspectives on the prevalence of persistent OD predominantly rely on self‐reported olfactory f…
View article: Association Between Multisensory Impairment and Depression Among Older Adults: A Population‐Based Analysis
Association Between Multisensory Impairment and Depression Among Older Adults: A Population‐Based Analysis Open
Objective In this study, we examine how impairments in vision, hearing, touch, and olfaction relate to depression in older adults, considering both individual and multisensory impairments (MSIs). Study Design Analysis of cross‐sectional da…
View article: Predictors of Sinonasal Improvement After Highly Effective Modulator Therapy in Adults with Cystic Fibrosis
Predictors of Sinonasal Improvement After Highly Effective Modulator Therapy in Adults with Cystic Fibrosis Open
Objectives The 22‐question SinoNasal Outcome Test (SNOT‐22) assesses chronic rhinosinusitis (CRS) severity. We aimed to identify predictors of SNOT‐22 score improvement following highly effective modulator therapy (HEMT) initiation and to …
View article: Postacute Sequelae of SARS-CoV-2 in Children
Postacute Sequelae of SARS-CoV-2 in Children Open
The coronavirus disease 2019 (COVID-19) pandemic has caused significant medical, social, and economic impacts globally, both in the short and long term. Although most individuals recover within a few days or weeks from an acute infection, …
View article: Delivering Therapy to the Olfactory Cleft: A Comparison of the Various Methods of Administering Topical Nasal Medications
Delivering Therapy to the Olfactory Cleft: A Comparison of the Various Methods of Administering Topical Nasal Medications Open
Background and objective Chronic rhinosinusitis (CRS) is an inflammatory condition affecting the nasal mucosa, and it causes olfactory dysfunction (OD) in up to 78.2% of patients. Corticosteroids are the mainstay of treatment to shrink nas…
View article: BMI Increases in Individuals with COVID-19-Associated Olfactory Dysfunction
BMI Increases in Individuals with COVID-19-Associated Olfactory Dysfunction Open
(1) Background: Reports suggest COVID-19-associated olfactory dysfunction (OD) may result in alterations in dietary behaviors and perceived weight change, but few studies using psychophysical evaluation of post-COVID-19-associated chemosen…
View article: The Serpentine Sign: A Reliable Endoscopic and Radiographic Finding in Empty Nose Syndrome
The Serpentine Sign: A Reliable Endoscopic and Radiographic Finding in Empty Nose Syndrome Open
Objective Empty nose syndrome (ENS) is a relatively uncommon disease that greatly impacts the quality of life and presents diagnostic challenges. We sought to identify objective clinical findings unique to patients with ENS, and in doing s…
View article: Accessing the Eustachian tube: Conventional nasal spray vs. exhalation delivery system and the impact of targeted endoscopic sinus surgery on topical distribution patterns
Accessing the Eustachian tube: Conventional nasal spray vs. exhalation delivery system and the impact of targeted endoscopic sinus surgery on topical distribution patterns Open
Background Eustachian tube dysfunction (ETD) may occur distinct from, or in conjunction with, chronic rhinosinusitis (CRS+ETD). Intranasal corticosteroid sprays are often prescribed for ETD, although ET distribution may be limited. To date…
View article: Immune-Epithelial Dynamics and Tissue Remodeling in Chronically Inflamed Nasal Epithelium via Multi-scaled Transcriptomics
Immune-Epithelial Dynamics and Tissue Remodeling in Chronically Inflamed Nasal Epithelium via Multi-scaled Transcriptomics Open
Chronic rhinosinusitis (CRS) is a common inflammatory disease of the sinonasal cavity that affects millions of individuals worldwide. The complex pathophysiology of CRS remains poorly understood, with emerging evidence implicating the orch…
View article: Olfaction and neurocognition after COVID-19: a scoping review
Olfaction and neurocognition after COVID-19: a scoping review Open
Introduction COVID-19 induces both acute and chronic neurological changes. Existing evidence suggests that chemosensory changes, particularly olfactory loss, may reflect central neurological dysfunction in neurodegenerative diseases and ma…
View article: Olfaction, body mass index, and quality of life with cystic fibrosis combination therapy
Olfaction, body mass index, and quality of life with cystic fibrosis combination therapy Open
Background Triple‐combination therapy of elexacaftor‐tezacaftor‐ivacaftor (ETI) has been shown to reduce morbidity and mortality in people with cystic fibrosis (PwCF). Although patient body mass index (BMI) favorably increases with ETI tre…
View article: Supplementary Figure Legends 1-5 from CD24 Is an Effector of HIF-1–Driven Primary Tumor Growth and Metastasis
Supplementary Figure Legends 1-5 from CD24 Is an Effector of HIF-1–Driven Primary Tumor Growth and Metastasis Open
PDF file - 90K
View article: Data from CD24 Is an Effector of HIF-1–Driven Primary Tumor Growth and Metastasis
Data from CD24 Is an Effector of HIF-1–Driven Primary Tumor Growth and Metastasis Open
Hypoxia drives malignant progression in part by promoting accumulation of the oncogenic transcription factor hypoxia inducible factor–1α (HIF-1α) in tumor cells. Tumor aggressiveness also relates to elevation of the cancer stem cell–associ…
View article: Supplementary Table 1 from CD24 Is an Effector of HIF-1–Driven Primary Tumor Growth and Metastasis
Supplementary Table 1 from CD24 Is an Effector of HIF-1–Driven Primary Tumor Growth and Metastasis Open
PDF file - 68K, Quantitation of visible lung for metastases after tail vein inoculation of UMUC-3 cell lines