Jonathan B. Trapani
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View article: Dehydration promotes intracellular lipid synthesis and accumulation
Dehydration promotes intracellular lipid synthesis and accumulation Open
Lipids can be considered a water reservoir used to offset dehydration stress as their oxidation by the mitochondria generates water. However, whether dehydration directly regulates lipid synthesis is unknown, which is the focus of this stu…
View article: Disruption of mitochondrial electron transport impairs urinary concentration via AMPK-dependent suppression of aquaporin 2
Disruption of mitochondrial electron transport impairs urinary concentration via AMPK-dependent suppression of aquaporin 2 Open
Urinary concentration is an energy-dependent process that minimizes body water loss by increasing aquaporin 2 (AQP2) expression in collecting duct (CD) principal cells. To investigate the role of mitochondrial (mt) ATP production in renal …
View article: Kidney collecting duct-derived vasopressin is not essential for appropriate concentration or dilution of urine
Kidney collecting duct-derived vasopressin is not essential for appropriate concentration or dilution of urine Open
Hypothalamic vasopressin is required for appropriate urinary concentration. However, whether collecting duct-derived vasopressin is involved remains unknown. We developed a novel transgenic mouse model to induce tissue-specific deletion of…
View article: Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress
Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress Open
Insulin-regulated aminopeptidase (IRAP) degrades vasopressin, but its role in urinary concentration and dilution is unknown. Here, we show that IRAP-deficient mice have a high urinary osmolality at baseline and are unable to excrete free w…