Jonathan H. Badger
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View article: Gut microbiota drive autoimmunity to neuroretina in a humanized gnotobiotic mouse model of spontaneous autoimmune uveitis 9300
Gut microbiota drive autoimmunity to neuroretina in a humanized gnotobiotic mouse model of spontaneous autoimmune uveitis 9300 Open
Description Autoimmune uveitis is a sight-threatening inflammation driven by retina-specific T cells. Using a transgenic mouse model of spontaneous autoimmune uveitis(R161H), we demonstrated that commensal gut flora can provide innate and …
View article: Comparative genomics of the niche-specific plant pathogen <i>Streptomyces ipomoeae</i> reveal novel genome content and organization
Comparative genomics of the niche-specific plant pathogen <i>Streptomyces ipomoeae</i> reveal novel genome content and organization Open
The sweet potato soil rot pathogen Streptomyces ipomoeae differs in disease pathology, host range, and virulence factor production from Streptomyces species that cause scab diseases on potato and other plant hosts. Nevertheless, previous p…
View article: Pathogenesis of flares in liver inflammation in hepatitis B virus-infected women during and after pregnancy
Pathogenesis of flares in liver inflammation in hepatitis B virus-infected women during and after pregnancy Open
Women with chronic hepatitis B (CHB) are at risk of increased liver inflammation during pregnancy. To investigate the pathogenesis of these hepatic flares we studied immune responses and gut microbiota in 19 women with CHB (12 without and …
View article: Human gut commensals support development of ocular autoimmunity in retina-specific T cell receptor transgenic mice
Human gut commensals support development of ocular autoimmunity in retina-specific T cell receptor transgenic mice Open
Autoimmune uveitis is a major cause of blindness, in which intraocular inflammation is driven by T cells that target the neuroretina. In a mouse model of spontaneous autoimmune uveitis (R161H), retina-specific T cells are primed in the gut…
View article: JAMS - A framework for the taxonomic and functional exploration of microbiological genomic data
JAMS - A framework for the taxonomic and functional exploration of microbiological genomic data Open
Shotgun microbiome sequencing analysis presents several challenges to accurately and consistently depict sample composition and functional potential. Here we present a two-part framework – JAMS (Just a Microbiology System) – whereby with r…
View article: Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response
Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response Open
Another benefit of dietary fiber The gut microbiome can modulate the immune system and influence the therapeutic response of cancer patients, yet the mechanisms underlying the effects of microbiota are presently unclear. Spencer et al . ad…
View article: Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients
Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients Open
New fecal microbiota for cancer patients The composition of the gut microbiome influences the response of cancer patients to immunotherapies. Baruch et al. and Davar et al. report first-in-human clinical trials to test whether fecal microb…
View article: Effect of neuromuscular electrical stimulation on the recovery of people with COVID-19 admitted to the intensive care unit: A narrative review
Effect of neuromuscular electrical stimulation on the recovery of people with COVID-19 admitted to the intensive care unit: A narrative review Open
The rehabilitation of patients with COVID-19 after prolonged treatment in the intensive care unit is often complex and challenging. Patients may develop a myriad of long-term multiorgan impairments, affecting the respiratory, cardiac, neur…
View article: Additional file 1 of Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence
Additional file 1 of Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence Open
Additional file 1: Vibrio parahaemolyticus Ortholog Match Table. BLAST-based ortholog Match Table of V. parahaemolyticus strains (XLS 2 MB)
View article: Additional file of Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence
Additional file of Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence Open
Additional file of Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence
View article: Additional file of Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence
Additional file of Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence Open
Additional file of Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence
View article: Additional file 2 of Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence
Additional file 2 of Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence Open
Additional file 2: Vibrio parahaemolyticus Single Nucleotide Polymorphisms. Single Nucleotide Polymorphisms of V. parahaemolyticus genomes relative to reference strain RIMD2210633 (XLS 5 MB)
View article: Laboratory mice born to wild mice have natural microbiota and model human immune responses
Laboratory mice born to wild mice have natural microbiota and model human immune responses Open
Born to be a wildling Inbred laboratory mouse strains are used extensively in basic and translational immunology research. However, the commensal and pathogenic repertoire of resident microbes encountered in the wild is not replicated in a…
View article: Colony formation in <i>Phaeocystis antarctica</i> : connecting molecular mechanisms with iron biogeochemistry
Colony formation in <i>Phaeocystis antarctica</i> : connecting molecular mechanisms with iron biogeochemistry Open
Phaeocystis antarctica is an important phytoplankter of the Ross Sea where it dominates the early season bloom after sea ice retreat and is a major contributor to carbon export. The factors that influence Phaeocystis colony formation and t…
View article: The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance
The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance Open
Commensal bacteria are critical for physiological functions in the gut, and dysbiosis in the gut may cause diseases. In this article, we report that mice deficient in cathelin-related antimicrobial peptide (CRAMP) were defective in the dev…