Jonathan Bernd
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View article: Accelerated maturation of <scp>ARPE</scp> ‐19 cells for the translational assessment of gene therapy
Accelerated maturation of <span>ARPE</span> ‐19 cells for the translational assessment of gene therapy Open
The human retinal pigment epithelium (RPE) cell line ARPE‐19 is widely used as an alternative to primary RPE despite losing many features of primary RPE. We aimed to determine whether a combination of RPE‐specific laminin (LN) and nicotina…
View article: Mitigation of human iris angiogenesis through <scp>uPAR</scp> / <scp>LRP</scp> ‐1 interaction antagonism in an organotypic ex vivo model
Mitigation of human iris angiogenesis through <span>uPAR</span> / <span>LRP</span> ‐1 interaction antagonism in an organotypic ex vivo model Open
Rubeosis Iridis (RI) is characterized by an increase in neovascularization and inflammation factors in the iris. During angiogenesis, the urokinase plasminogen activator (uPA) and its receptor (uPAR) play a pivotal role in extracellular ma…
The Methyltransferase Smyd1 Mediates LPS-Triggered Up-Regulation of IL-6 in Endothelial Cells Open
The lysine methyltransferase Smyd1 with its characteristic catalytic SET-domain is highly enriched in the embryonic heart and skeletal muscles, participating in cardiomyogenesis, sarcomere assembly and chromatin remodeling. Recently, signi…
View article: Structural Microangiopathies in Skeletal Muscle Related to Systemic Vascular Pathologies in Humans
Structural Microangiopathies in Skeletal Muscle Related to Systemic Vascular Pathologies in Humans Open
It is unclear how microangiopathic changes in skeletal muscle vary among systemic vascular pathologies. We therefore analyzed the capillary fine structure in skeletal muscle from patients with arterial hypertension (HYPT), diabetes mellitu…
ZNF580 – a brake on Interleukin-6 Open
This study demonstrated that ZNF580 inhibits LPS-induced expression of IL-6. ZNF580 was highly expressed in monocytic cells and therefore may contribute to the modulation of its IL-6 production, at least in response to LPS. This suggests c…
PET imaging of the proliferation in <i>Ye</i>-infected mice and the histological findings. Open
(A) Coronal [18F]FLT-PET and fused PET and MR images from PBS-treated (n = 3), low- (n = 7) and high dose- (n = 8) infected mice 3 days p.i. The arrows indicate the positions of the spleens, which showed no increased uptake of [18F]FLT in …