Jonathan Boss
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View article: Statistical Methods for Chemical Mixtures: A Roadmap for Practitioners Using Simulation Studies and a Sample Data Analysis in the PROTECT Cohort
Statistical Methods for Chemical Mixtures: A Roadmap for Practitioners Using Simulation Studies and a Sample Data Analysis in the PROTECT Cohort Open
We develop an integrated R package "CompMix" that provides a platform for mixtures analysis where the practitioners can implement a pipeline that includes several approaches for mixtures analysis. Our study offers guidelines for selecting …
View article: Residential exposure associations with ALS risk, survival, and phenotype: a Michigan-based case-control study
Residential exposure associations with ALS risk, survival, and phenotype: a Michigan-based case-control study Open
Residential exposures may be important modifiable components of the ALS susceptibility and prognosis exposome.
View article: Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank
Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank Open
Background and Objectives Amyotrophic lateral sclerosis (ALS) causes profound impairments in neurological function and a cure for this devastating disease remains elusive. Early detection and risk stratification are crucial for timely inte…
View article: Statistical methods for chemical mixtures: a roadmap for practitioners
Statistical methods for chemical mixtures: a roadmap for practitioners Open
Quantitative characterization of the health impacts associated with exposure to chemical mixtures has received considerable attention in current environmental and epidemiological studies. With many existing statistical methods and emerging…
View article: Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study
Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study Open
View article: Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort
Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort Open
Background Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurogenerative disease caused by combined genetic susceptibilities and environmental exposures. Identifying and validating these exposures are of paramount importance …
View article: Mediation with External Summary Statistic Information (MESSI)
Mediation with External Summary Statistic Information (MESSI) Open
Environmental health studies are increasingly measuring endogenous omics data ($\boldsymbol{M}$) to study intermediary biological pathways by which an exogenous exposure ($\boldsymbol{A}$) affects a health outcome ($\boldsymbol{Y}$), given…
View article: Group Inverse-Gamma Gamma Shrinkage for Sparse Linear Models with Block-Correlated Regressors
Group Inverse-Gamma Gamma Shrinkage for Sparse Linear Models with Block-Correlated Regressors Open
Heavy-tailed continuous shrinkage priors, such as the horseshoe prior, are widely used for sparse estimation problems. However, there is limited work extending these priors to explicitly incorporate multivariate shrinkage for regressors wi…
View article: Shrinkage Methods for High-Dimensional Regression and Mediation Models
Shrinkage Methods for High-Dimensional Regression and Mediation Models Open
With advances in high throughput assaying technology, environmental health scientists are increasingly interested in characterizing the joint effects of a set of exogenous environmental exposures (A) coupled with endogenous omics data on a…
View article: Persistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length in the National Health and Nutrition Examination Survey
Persistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length in the National Health and Nutrition Examination Survey Open
View article: Body mass index associates with amyotrophic lateral sclerosis survival and metabolomic profiles
Body mass index associates with amyotrophic lateral sclerosis survival and metabolomic profiles Open
Introduction/Aims Body mass index (BMI) is linked to amyotrophic lateral sclerosis (ALS) risk and prognosis, but additional research is needed. The aim of this study was to identify whether and when historical changes in BMI occurred in AL…
View article: Occupational history associates with ALS survival and onset segment
Occupational history associates with ALS survival and onset segment Open
Occupational settings and self-reported exposures influence ALS survival and onset segment. Further studies are needed to explore and understand these relationships, most advantageously using prospective cohorts and detailed ALS registries.
View article: Persistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length: Evidence from NHANES 1999-2002
Persistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length: Evidence from NHANES 1999-2002 Open
Background/Aims: Despite racial disparities in diseases of aging and premature mortality, non-Hispanic Black Americans tend to have longer leukocyte telomere length (LTL), a biomarker of cellular aging, than non-Hispanic White Americans. P…
View article: Assessing the added value of linking electronic health records to improve the prediction of self-reported COVID-19 testing and diagnosis
Assessing the added value of linking electronic health records to improve the prediction of self-reported COVID-19 testing and diagnosis Open
Since the beginning of the Coronavirus Disease 2019 (COVID-19) pandemic, a focus of research has been to identify risk factors associated with COVID-19-related outcomes, such as testing and diagnosis, and use them to build prediction model…
View article: Associations of self-reported occupational exposures and settings to ALS: a case–control study
Associations of self-reported occupational exposures and settings to ALS: a case–control study Open
View article: Variable Selection with Multiply-Imputed Datasets: Choosing Between Stacked and Grouped Methods
Variable Selection with Multiply-Imputed Datasets: Choosing Between Stacked and Grouped Methods Open
Penalized regression methods are used in many biomedical applications for variable selection and simultaneous coefficient estimation. However, missing data complicates the implementation of these methods, particularly when missingness is h…
View article: Variable selection with multiply-imputed datasets: choosing between stacked and grouped methods
Variable selection with multiply-imputed datasets: choosing between stacked and grouped methods Open
Penalized regression methods are used in many biomedical applications for variable selection and simultaneous coefficient estimation. However, missing data complicates the implementation of these methods, particularly when missingness is h…
View article: Variable Selection with Multiply-Imputed Datasets: Choosing Between Stacked and Grouped Methods
Variable Selection with Multiply-Imputed Datasets: Choosing Between Stacked and Grouped Methods Open
Penalized regression methods are used in many biomedical applications for variable selection and simultaneous coefficient estimation. However, missing data complicates the implementation of these methods, particularly when missingness is h…
View article: A hierarchical integrative group least absolute shrinkage and selection operator for analyzing environmental mixtures
A hierarchical integrative group least absolute shrinkage and selection operator for analyzing environmental mixtures Open
Environmental health studies are increasingly measuring multiple pollutants to characterize the joint health effects attributable to exposure mixtures. However, the underlying dose‐response relationship between toxicants and health outcome…
View article: Amyotrophic Lateral Sclerosis Survival Associates With Neutrophils in a Sex-specific Manner
Amyotrophic Lateral Sclerosis Survival Associates With Neutrophils in a Sex-specific Manner Open
This study provides Class III evidence that in female participants with ALS, higher baseline neutrophil counts are associated with shorter survival.
View article: Group Inverse-Gamma Gamma Shrinkage for Sparse Regression with Block-Correlated Predictors
Group Inverse-Gamma Gamma Shrinkage for Sparse Regression with Block-Correlated Predictors Open
Heavy-tailed continuous shrinkage priors, such as the horseshoe prior, are widely used for sparse estimation problems. However, there is limited work extending these priors to predictors with grouping structures. Of particular interest in …
View article: Do black/white differences in telomere length depend on socioeconomic status?
Do black/white differences in telomere length depend on socioeconomic status? Open
Social and economic disadvantage are hypothesized to increase the risk of disease and death via accelerated biological aging. Given that US blacks are socially and economically disadvantaged relative to whites, health disparities scholars …
View article: Untargeted metabolomics yields insight into ALS disease mechanisms
Untargeted metabolomics yields insight into ALS disease mechanisms Open
Objective To identify dysregulated metabolic pathways in amyotrophic lateral sclerosis (ALS) versus control participants through untargeted metabolomics. Methods Untargeted metabolomics was performed on plasma from ALS participants (n=125)…
View article: A Hierarchical Integrative Group LASSO (HiGLASSO) Framework for Analyzing Environmental Mixtures
A Hierarchical Integrative Group LASSO (HiGLASSO) Framework for Analyzing Environmental Mixtures Open
Environmental health studies are increasingly measuring multiple pollutants to characterize the joint health effects attributable to exposure mixtures. However, the underlying dose-response relationship between toxicants and health outcome…
View article: Variable selection with multiply-imputed datasets: choosing between stacked and grouped methods
Variable selection with multiply-imputed datasets: choosing between stacked and grouped methods Open
Penalized regression methods, such as lasso and elastic net, are used in many biomedical applications when simultaneous regression coefficient estimation and variable selection is desired. However, missing data complicates the implementati…
View article: Maternal blood metal and metalloid concentrations in association with birth outcomes in Northern Puerto Rico
Maternal blood metal and metalloid concentrations in association with birth outcomes in Northern Puerto Rico Open
View article: Predictors of urinary and blood Metal(loid) concentrations among pregnant women in Northern Puerto Rico
Predictors of urinary and blood Metal(loid) concentrations among pregnant women in Northern Puerto Rico Open
View article: Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals
Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals Open
View article: Estimating Outcome-Exposure Associations when Exposure Biomarker Detection Limits vary Across Batches
Estimating Outcome-Exposure Associations when Exposure Biomarker Detection Limits vary Across Batches Open
Limit of detection (LOD) issues are ubiquitous in exposure assessment. Although there is an extensive literature on modeling exposure data under such imperfect measurement processes, including likelihood-based methods and multiple imputati…
View article: Association Between Life Purpose and Mortality Among US Adults Older Than 50 Years
Association Between Life Purpose and Mortality Among US Adults Older Than 50 Years Open
This study's results indicated that stronger purpose in life was associated with decreased mortality. Purposeful living may have health benefits. Future research should focus on evaluating the association of life purpose interventions with…