Jia Chen
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View article: Integrating transcriptomics with metabolomics reveals the differential mechanisms underlying the color and volatile substances of Amomum tsao-ko
Integrating transcriptomics with metabolomics reveals the differential mechanisms underlying the color and volatile substances of Amomum tsao-ko Open
Amomum tsao-ko is a significant medicinal and edible plant, recognized for its distinctive aroma. The pericarp color varies among different cultivars, yet the relationship between pericarp color and both edible and medicinal values, as wel…
View article: Maxing Shigan Decoction Mitigates Mycoplasma pneumonia-Induced Pyroptosis in A549 Cells via the NLRP3 Inflammasome [Retraction]
Maxing Shigan Decoction Mitigates Mycoplasma pneumonia-Induced Pyroptosis in A549 Cells via the NLRP3 Inflammasome [Retraction] Open
[This retracts the article DOI: 10.2147/IDR.S292413.].
View article: Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome
Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome Open
Interstitial renal inflammation contributes to the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Recently, lactylation modification has emerged as a mechanism for mediating chronic organ damage. We investigate …
View article: Transcriptomics and metabolomics profiling of Paris polyphylla var. yunnanensis with different growth years
Transcriptomics and metabolomics profiling of Paris polyphylla var. yunnanensis with different growth years Open
Paris polyphylla var. yunnanensis is a widely cultivated rhizomatous perennial woody plant known for producing highly valued steroidal saponins. Steroidal saponins serve as the primary active components and exhibit a variety of pharmacolog…
View article: Fingolimod ameliorates amyloid deposition and neurodegeneration in APP/PS1 mouse model of Alzheimer's disease
Fingolimod ameliorates amyloid deposition and neurodegeneration in APP/PS1 mouse model of Alzheimer's disease Open
This study illustrates that fingolimod effectively ameliorates multiple pathological features of AD, highlighting its potential as a promising therapeutic candidate for the disease.
View article: A bibliometric study: Relevant studies on scar laser therapy since the 21st century
A bibliometric study: Relevant studies on scar laser therapy since the 21st century Open
To summarise research studies on scar laser therapy since the 21st century using bibliometric methods, and to speculate on the possible development in the future. The literature about scar laser therapy in Web of Science database was searc…
View article: Ibuprofen treatment for patent ductus arteriosus in preterm infants: a retrospective cohort study in a leading Chinese center
Ibuprofen treatment for patent ductus arteriosus in preterm infants: a retrospective cohort study in a leading Chinese center Open
Objective There is a dilemma of ibuprofen treatment with patent ductus arteriosus (PDA) as to how and when to treat. We aimed to clarify this issue in very preterm infants (VPIs; < 32 weeks). Methods This retrospective study included 1 659…
View article: Predictive value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and lymphocyte-to-monocyte ratio (LMR) in patients with non-small cell lung cancer after radical lung cancer surgery
Predictive value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and lymphocyte-to-monocyte ratio (LMR) in patients with non-small cell lung cancer after radical lung cancer surgery Open
Preoperative HALP versus LMR are independent predictive aspect within NSCLC diseased persons linked to clinicopathological features, and has a particular value in determining bodement.
View article: Bacillus amyloliquefaciens B10 can alleviate aflatoxin B1-induced kidney oxidative stress and apoptosis in mice
Bacillus amyloliquefaciens B10 can alleviate aflatoxin B1-induced kidney oxidative stress and apoptosis in mice Open
Aflatoxin B1(AFB1) widely exists in food and feed, which seriously endangers human and animal health. How to detoxify AFB1 is a research hotspot at present. This study attempts to use the Bacillus amyloliquefaciens B10, one of probiotics s…
View article: Maxing Shigan Decoction Mitigates Mycoplasma pneumonia-Induced Pyroptosis in A549 Cells via the NLRP3 Inflammasome
Maxing Shigan Decoction Mitigates Mycoplasma pneumonia-Induced Pyroptosis in A549 Cells via the NLRP3 Inflammasome Open
MXSG mitigates M. pneumoniae-induced pyroptosis in A549 cells via the NLRP3 inflammasome.
View article: Transperineal-incision urethrectomy combined with laparoscopic prostatectomy for a male patient with squamous cell carcinoma involving distal plus proximal urethra and untypical symptoms—a case report
Transperineal-incision urethrectomy combined with laparoscopic prostatectomy for a male patient with squamous cell carcinoma involving distal plus proximal urethra and untypical symptoms—a case report Open
Primary urethral carcinoma (PUC) is a rare malignancy, covering less than 1% of all genitourinary cancers. Different tumor location, classified as tumor in distal or proximal urethra, represents different characteristics and often leads to…
View article: Tubular decoy receptor 2 as a predictor of prognosis in patients with immunoglobulin A nephropathy
Tubular decoy receptor 2 as a predictor of prognosis in patients with immunoglobulin A nephropathy Open
Background Accelerated senescence of renal tubular epithelial cells (RTECs) might contribute to immunoglobulin A nephropathy (IgAN) progression. This study aimed to determine whether the RTEC senescence marker, decoy receptor 2 (DcR2), cou…
View article: Metformin Synergistically Enhanced the Antitumor Activity of Celecoxib in Human Non-Small Cell Lung Cancer Cells
Metformin Synergistically Enhanced the Antitumor Activity of Celecoxib in Human Non-Small Cell Lung Cancer Cells Open
Celecoxib has potential as an effective antineoplastic agent, but it may exhibit side effects. Given the glucose-addicted properties of tumor cells, metformin is recognized for its inhibitory effect on oxidative phosphorylation. In the pre…
View article: The Comparison of HHHFNC and NCPAP in Extremely Low-Birth-Weight Preterm Infants After Extubation: A Single-Center Randomized Controlled Trial
The Comparison of HHHFNC and NCPAP in Extremely Low-Birth-Weight Preterm Infants After Extubation: A Single-Center Randomized Controlled Trial Open
Objectives: To compare the clinical efficacy of heated, humidified high-flow nasal cannula (HHHFNC) and nasal continuous positive airway pressure (NCPAP) in extremely low-birth-weight preterm infants (ELBWI) after extubation. Methods: This…
View article: Predictive Model for Oral Mucositis of Nasopharyngeal Carcinoma Patients Receiving Chemo-radiotherapy
Predictive Model for Oral Mucositis of Nasopharyngeal Carcinoma Patients Receiving Chemo-radiotherapy Open
Purpose To analyze risk factors for severe acute oral mucositis of nasopharyngeal carcinoma patients (NPCs) receiving chemo-radiotherapy and build predictive models. Methods 270 NPCs receiving radical chemo-radiotherapy were included. Oral…
View article: P0969PARKIN INHIBITS THE PROGRESSION OF DIABETIC NEPHROPATHY BY PROMOTING GATA4 DEGRADATION TO REDUCE THE SENESCENCE OF RENAL TUBULAR CELLS
P0969PARKIN INHIBITS THE PROGRESSION OF DIABETIC NEPHROPATHY BY PROMOTING GATA4 DEGRADATION TO REDUCE THE SENESCENCE OF RENAL TUBULAR CELLS Open
Background and Aims Diabetic nephropathy (DN) can cause end-stage renal disease. During the progression of DN, hyperglycemia accelerates the senescence of renal tubular epithelial cells (RTECs), leading to the tubulointerstitial inflammati…
View article: P1141CT IMAGING FEATURES AND INFLUENCE FACTORS IN PEROTONEAL DIALYSIS RELATED PERITONEAL INJURY
P1141CT IMAGING FEATURES AND INFLUENCE FACTORS IN PEROTONEAL DIALYSIS RELATED PERITONEAL INJURY Open
Background and Aims Peritoneal dialysis (PD) is one of the most important renal replacement methods for end-stage renal disease. CT scan found some patients have peritoneal thickening, omental structure change. However, the underlying regu…
View article: P0674DCR2,AS A SENESCENCE MARKER,IS ASSOCIATED WITH DISEASE SEVERITY AND PROGRESSION IN IGA NEPHROPATHY PATIENTS
P0674DCR2,AS A SENESCENCE MARKER,IS ASSOCIATED WITH DISEASE SEVERITY AND PROGRESSION IN IGA NEPHROPATHY PATIENTS Open
Background and Aims Accelerated senescence of renal tubular epithelial cells (RTECs) may contribute to the progression of IgA Nephropathy (IgAN). Our previous studies demonstrated that DcR2 may reflect senescence of RTECs in experimental m…
View article: Cumulative Evidence for Associations between Genetic Variants and Risk of Esophageal Cancer
Cumulative Evidence for Associations between Genetic Variants and Risk of Esophageal Cancer Open
Background: A large number of studies have been conducted to investigate associations between genetic variants and esophageal cancer risk in the past several decades. However, findings from these studies have been generally inconsistent. W…
View article: FP635Screening for peritoneal fibrosis in patients on peritoneal dialysis: role of CT scanning
FP635Screening for peritoneal fibrosis in patients on peritoneal dialysis: role of CT scanning Open
INTRODUCTION: Dry weight evaluation remains challenging in the end-stage renal disease (ESRD) patients treated with the hemodiafiltration (HDF).Optimal hydration status (HS) is essential for preventing the incidence of the cardiovascular d…
View article: [Comparison of clinical efficacy of two noninvasive respiratory support therapies for respiratory distress syndrome in very low birth weight preterm infants].
[Comparison of clinical efficacy of two noninvasive respiratory support therapies for respiratory distress syndrome in very low birth weight preterm infants]. Open
As an initial respiratory support for very low birth weight preterm infants with RDS, HHHFNC has a similar clinical effect as NIPPV, suggesting that HHHFNC is a safe and effective clinical option as a non-invasive ventilation treatment.
View article: Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives
Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives Open
In this study, in order to find novel biologically active pyrazole oxime derivatives, twenty-eight new pyrazole oxime compounds containing a substituted isoxazole ring were synthesized and evaluated for their acaricidaland insecticidal act…
View article: Abnormal amplitude of low-frequency fluctuations associated with rapid-eye movement in chronic primary insomnia patients
Abnormal amplitude of low-frequency fluctuations associated with rapid-eye movement in chronic primary insomnia patients Open
These findings suggest that hyperarousal reflected by ALFF abnormality within brain areas related to cognition and emotion in insomnia associated with REM sleep.