Jonathan C. Haydak
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View article: Liquid Biopsy-Multiomics Link Adhesion Pathway Dysregulation to Kidney Injury Severity
Liquid Biopsy-Multiomics Link Adhesion Pathway Dysregulation to Kidney Injury Severity Open
View article: A high-throughput microfabricated platform for rapid quantification of metastatic potential
A high-throughput microfabricated platform for rapid quantification of metastatic potential Open
Assays that measure morphology, proliferation, motility, deformability, and migration are used to study the invasiveness of cancer cells. However, native invasive potential of cells may be hidden from these contextual metrics because they …
View article: Integrated multiomics implicates dysregulation of ECM and cell adhesion pathways as drivers of severe COVID-associated kidney injury
Integrated multiomics implicates dysregulation of ECM and cell adhesion pathways as drivers of severe COVID-associated kidney injury Open
COVID-19 has been a significant public health concern for the last four years; however, little is known about the mechanisms that lead to severe COVID-associated kidney injury. In this multicenter study, we combined quantitative deep urina…
View article: Role of biophysics and mechanobiology in podocyte physiology
Role of biophysics and mechanobiology in podocyte physiology Open
View article: Deep learning on electronic medical records identifies distinct subphenotypes of diabetic kidney disease driven by genetic variations in the<i>Rho</i>pathway
Deep learning on electronic medical records identifies distinct subphenotypes of diabetic kidney disease driven by genetic variations in the<i>Rho</i>pathway Open
A bstract Kidney disease affects 50% of all diabetic patients; however, prediction of disease progression has been challenging due to inherent disease heterogeneity. We use deep learning to identify novel genetic signatures prognostically …
View article: #3119 DEEP LEARNING IDENTIFIES SUBPHENOTYPES OF DIABETIC KIDNEY DISEASE DRIVEN BY GENETIC VARIATIONS IN THE RHO PATHWAY
#3119 DEEP LEARNING IDENTIFIES SUBPHENOTYPES OF DIABETIC KIDNEY DISEASE DRIVEN BY GENETIC VARIATIONS IN THE RHO PATHWAY Open
Background and Aims Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease (ESKD), however therapies targeting causal pathways have been limited by disease heterogeneity. Integrating electronic health record (EHR) dat…
View article: KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression
KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression Open
Despite recent progress in the identification of mediators of podocyte injury, mechanisms underlying podocyte loss remain poorly understood, and cell-specific therapy is lacking. We previously reported that kidney and brain expressed prote…
View article: Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion
Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion Open
View article: LIM-Nebulette Reinforces Podocyte Structural Integrity by Linking Actin and Vimentin Filaments
LIM-Nebulette Reinforces Podocyte Structural Integrity by Linking Actin and Vimentin Filaments Open
Significance Statement The functional basis of the spatial cytoskeletal organization in the kidney podocyte that gives rise to its unique interdigitating morphology has been elusive. An integrative approach identified a novel podocyte-spec…
View article: Screening Diffusion of Small Molecules in Flexible Zeolitic Imidazolate Frameworks Using a DFT-Parameterized Force Field
Screening Diffusion of Small Molecules in Flexible Zeolitic Imidazolate Frameworks Using a DFT-Parameterized Force Field Open
Quantitatively modeling adsorbate diffusion through zeolitic imidazolate frameworks (ZIFs) must account for the inherent flexibility of these materials. Here, the lack of a transferable intramolecular ZIF force field (FF) for use in classi…
View article: Patient Priorities for Research Involving Peritoneal Dialysis
Patient Priorities for Research Involving Peritoneal Dialysis Open
In any routine meeting of patients on dialysis with their nephrologist, the topic of discussion is usually dominated by an assessment of how well recent laboratory work falls into the desired ranges. There is good reason for this quantitat…