Jonathan D. Casey
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View article: Exception from Informed Consent and Waiver of Informed Consent for Comparative Effectiveness Trials in Emergency Care Research
Exception from Informed Consent and Waiver of Informed Consent for Comparative Effectiveness Trials in Emergency Care Research Open
For many of the decisions made in the clinical care setting, clinicians lack evidence to inform which treatment would result in the best patient outcomes. This problem is particularly common in emergency care, a field in which the conditio…
View article: Early Whole Bowel Irrigation to Treat Colchicine Overdose: A Brief Review of 30 Years of Decontamination Strategies
Early Whole Bowel Irrigation to Treat Colchicine Overdose: A Brief Review of 30 Years of Decontamination Strategies Open
A case of colchicine overdose of 27 mg, or 0.27 mg/kg (weight 99.8 kg), is reported to assess the potential symptoms seen with this type of toxicity and analyze a prospective treatment for successful outcomes. A 74-year-old man unintention…
View article: Protocol and Statistical Analysis Plan for the ECMO-Free Trial: A Multicenter Randomized Controlled Trial
Protocol and Statistical Analysis Plan for the ECMO-Free Trial: A Multicenter Randomized Controlled Trial Open
Take-Home Points Study Question Does a daily protocolized assessment of readiness for decannulation from venovenous extracorporeal membrane oxygenation (V-V ECMO) shorten the time to decannulation? Results This manuscript describes the pro…
View article: Effectiveness of 2024–2025 COVID-19 Vaccination Against COVID-19 Hospitalization and Severe In-Hospital Outcomes — IVY Network, 26 Hospitals, September 1, 2024–April 30, 2025
Effectiveness of 2024–2025 COVID-19 Vaccination Against COVID-19 Hospitalization and Severe In-Hospital Outcomes — IVY Network, 26 Hospitals, September 1, 2024–April 30, 2025 Open
Importance As SARS-CoV-2 JN.1 lineage descendants continue to evolve, evaluating COVID-19 vaccine effectiveness (VE) against severe COVID-19 is necessary to inform vaccine composition updates. Objective To estimate effectiveness of 2024–20…
View article: Incidence Rates of RSV‐Associated Hospitalizations Among Adults in Middle Tennessee, United States, October 2022 Through September 2023
Incidence Rates of RSV‐Associated Hospitalizations Among Adults in Middle Tennessee, United States, October 2022 Through September 2023 Open
We estimated the burden of RSV‐associated hospitalizations in US adults 1 year prior to RSV vaccine introduction. The overall annual incidence rate of RSV‐associated hospitalization was 31.47 (95% CI: 21.89–43.97) per 100,000 adults. Rates…
View article: Treatment with Allogenic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multi-Center, Phase 2b Clinical Trial (STAT)
Treatment with Allogenic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multi-Center, Phase 2b Clinical Trial (STAT) Open
gov, ID: NCT03818854.
View article: Robotic versus Electromagnetic Bronchoscopy for Peripheral Pulmonary Lesions: A Randomized Trial (RELIANT)
Robotic versus Electromagnetic Bronchoscopy for Peripheral Pulmonary Lesions: A Randomized Trial (RELIANT) Open
Rationale: Robotic-assisted bronchoscopy has emerged as an alternative to electromagnetic navigational bronchoscopy for patients undergoing bronchoscopic biopsy of a peripheral pulmonary lesion. Although both platforms are routinely used i…
View article: Protocol and Statistical Analysis Plan for the Vasopressin for Septic Shock Pragmatic (VASSPR) Cluster-Crossover Randomized Trial
Protocol and Statistical Analysis Plan for the Vasopressin for Septic Shock Pragmatic (VASSPR) Cluster-Crossover Randomized Trial Open
Background: Guidelines recommend vasopressin as the preferred second-line vasopressor for treatment of septic shock. However, the optimal threshold for vasopressin initiation is unclear. Research Question: Does a treatment strategy using a…
View article: A framework for health systems to assess and prioritize participation in pragmatic clinical trials
A framework for health systems to assess and prioritize participation in pragmatic clinical trials Open
Introduction Pragmatic clinical trials (PCTs) are frequently embedded within settings in which patients receive their routine clinical care. The health care institutions that deliver routine clinical care must therefore decide how they pri…
View article: Multimorbidity Profiles and Severe In-Hospital Outcomes in Adults with Respiratory Syncytial Virus
Multimorbidity Profiles and Severe In-Hospital Outcomes in Adults with Respiratory Syncytial Virus Open
Background Adults hospitalized with acute respiratory infections, including respiratory syncytial virus (RSV), often have multiple underlying conditions. Few data are available on the combined effect of conditions on risk of severe outcome…
View article: Evidence-based Emergency Tracheal Intubation
Evidence-based Emergency Tracheal Intubation Open
Millions of critically ill adults undergo tracheal intubation in an emergency department or ICU each year, nearly 40% of whom experience hypoxemia, hypotension, or cardiac arrest during the procedure. Over the last two decades, a series of…
View article: Effect of Oxygen Saturation Targets on Neurologic Outcomes after Cardiac Arrest: A Secondary Analysis of the PILOT Trial
Effect of Oxygen Saturation Targets on Neurologic Outcomes after Cardiac Arrest: A Secondary Analysis of the PILOT Trial Open
Background More than 600,000 adults in the United States experience a cardiac arrest each year. After resuscitation from cardiac arrest, most patients receive mechanical ventilation. The oxygenation target that optimizes neurologic outcome…
View article: Video vs Direct Laryngoscopy for Tracheal Intubation After Cardiac Arrest
Video vs Direct Laryngoscopy for Tracheal Intubation After Cardiac Arrest Open
Among adults undergoing tracheal intubation after experiencing cardiac arrest, use of video laryngoscopy was associated with increased incidence of successful intubation on the first attempt and shortened duration of laryngoscopy, compared…
View article: Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia
Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia Open
Fostamatinib, a spleen tyrosine kinase inhibitor, has been reported to improve outcomes of COVID-19. To evaluate the efficacy and safety of fostamatinib in adults hospitalized with COVID-19 and hypoxemia. This multicenter, phase 3, placebo…
View article: Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia
Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia Open
Importance Fostamatinib, a spleen tyrosine kinase inhibitor, has been reported to improve outcomes of COVID-19. Objective To evaluate the efficacy and safety of fostamatinib in adults hospitalized with COVID-19 and hypoxemia. Design, Setti…
View article: Association Between Neuromuscular Blocking Agents and Outcomes of Emergency Tracheal Intubation: A Secondary Analysis of Randomized Trials
Association Between Neuromuscular Blocking Agents and Outcomes of Emergency Tracheal Intubation: A Secondary Analysis of Randomized Trials Open
Among critically ill adults undergoing tracheal intubation, the incidences of successful intubation on the first attempt and severe complications were not significantly different between patients who received succinylcholine and patients w…
View article: Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Trial
Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Trial Open
Rationale For critically ill adults receiving invasive mechanical ventilation, the ventilator mode determines how breaths are delivered. Whether the choice of ventilator mode affects outcomes for critically ill patients is unknown. To comp…
View article: RSV Vaccine Effectiveness Against Hospitalization Among US Adults 60 Years and Older
RSV Vaccine Effectiveness Against Hospitalization Among US Adults 60 Years and Older Open
This study evaluates the effectiveness of the respiratory syncytial virus vaccine against hospitalization for acute respiratory illness among US adults aged 60 years and older.
View article: Effectiveness of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccination Against SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 Lineage Hospitalization and a Comparison of Clinical Severity—IVY Network, 26 Hospitals, 18 October 2023–9 March 2024
Effectiveness of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccination Against SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 Lineage Hospitalization and a Comparison of Clinical Severity—IVY Network, 26 Hospitals, 18 October 2023–9 March 2024 Open
Background Assessing variant-specific coronavirus disease 2019 (COVID-19) vaccine effectiveness (VE) and severity can inform public health risk assessments and decisions about vaccine composition. BA.2.86 and its descendants, including JN.…
View article: Effectiveness of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccination Against SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 Lineage Hospitalization and a Comparison of Clinical Severity — IVY Network, 26 Hospitals, October 18, 2023–March 9, 2024
Effectiveness of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccination Against SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 Lineage Hospitalization and a Comparison of Clinical Severity — IVY Network, 26 Hospitals, October 18, 2023–March 9, 2024 Open
Background Assessing COVID-19 vaccine effectiveness (VE) and severity of SARS-CoV-2 variants can inform public health risk assessments and decisions about vaccine composition. BA.2.86 and its descendants, including JN.1 (referred to collec…
View article: Severity of Respiratory Syncytial Virus vs COVID-19 and Influenza Among Hospitalized US Adults
Severity of Respiratory Syncytial Virus vs COVID-19 and Influenza Among Hospitalized US Adults Open
Importance On June 21, 2023, the Centers for Disease Control and Prevention recommended the first respiratory syncytial virus (RSV) vaccines for adults aged 60 years and older using shared clinical decision-making. Understanding the severi…