Jonathan Chernoff
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View article: PAK2-driven cytoskeleton–endosome dynamics control macrophage hyperphagia and SIRPA engagement
PAK2-driven cytoskeleton–endosome dynamics control macrophage hyperphagia and SIRPA engagement Open
Macrophages rely on dynamic cytoskeletal rearrangements to respond to their environment. This plasticity supports biomechanical transitions and functional polarization, mediating tissue homeostasis, antimicrobial defense, and repair proces…
View article: PAK1 regulates oligodendroglial proliferation and repopulation in homeostatic and demyelinating brain
PAK1 regulates oligodendroglial proliferation and repopulation in homeostatic and demyelinating brain Open
Activating mutations in p21-activated kinase 1 (PAK1) cause intellectual disability, neurodevelopmental abnormality, macrocephaly, and white matter anomaly in children. Oligodendroglial lineage cells undergo extensive proliferation and pop…
View article: Treatment discontinuation associated with perioperative toxicity of FLOT versus XELOX chemotherapy in patients with resectable gastric cancer: prospective randomized trial (PECORINO)
Treatment discontinuation associated with perioperative toxicity of FLOT versus XELOX chemotherapy in patients with resectable gastric cancer: prospective randomized trial (PECORINO) Open
ClinicalTrials.gov ID NCT04937738.
View article: Supplementary Table 1 from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon
Supplementary Table 1 from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon Open
Table S1. sgRNA sequences and drop-out screen results.
View article: Data from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon
Data from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon Open
Breast cancers of the Integrative Cluster 2 (IntClust-2) type, characterized by amplification of a small portion of chromosome 11, have a median survival of only 5 years. Several cancer-relevant genes occupy this portion of chromosome 11, …
View article: Supplementary Table 2 from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon
Supplementary Table 2 from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon Open
Table S2. IC50 Values of P4HA3 and SERPINH1 against IntClust-2 and non-IntClust-2 cell lines.
View article: Supplementary Figure 1 from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon
Supplementary Figure 1 from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon Open
Figure S1. siRNA-mediated wound healing assay
View article: Supplementary Figure 2 from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon
Supplementary Figure 2 from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon Open
Figure S2. Chemical structures of the three key compounds.
View article: Supplementary Figure 3 from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon
Supplementary Figure 3 from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon Open
Figure S3. Drug-mediated wound healing assay.
View article: KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation
KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation Open
Oncogenic KRAS mutations are prevalent in colorectal cancer (CRC) and linked to poor prognosis and therapeutic resistance. Emerging evidence suggests that specific KRAS mutations differentially influence treatment responses. In this study,…
View article: Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon
Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon Open
Breast cancers of the Integrative Cluster 2 (IntClust-2) type, characterized by amplification of a small portion of chromosome 11, have a median survival of only 5 years. Several cancer-relevant genes occupy this portion of chromosome 11, …
View article: The role of RAC1 in resistance to targeted therapies in cancer
The role of RAC1 in resistance to targeted therapies in cancer Open
RAC1 is a small 21 kDa RHO GTPase that plays a pivotal role in regulating actin cytoskeletal dynamics and cell growth. Alterations in the activity of RAC1 are implicated in a range of diseases, including cancer. Increased RAC1 activity, du…
View article: Synergistic effect of PAK and Hippo pathway inhibitor combination in NF2-deficient Schwannoma
Synergistic effect of PAK and Hippo pathway inhibitor combination in NF2-deficient Schwannoma Open
Neurofibromatosis type 2 is a genetic disorder that results in the formation and progressive growth of schwannomas, ependymomas, and/or meningiomas. The NF2 gene encodes the Merlin protein, which links cell cortical elements to the actin c…
View article: Control of OPC proliferation and repopulation by the intellectual disability gene PAK1 under homeostatic and demyelinating conditions
Control of OPC proliferation and repopulation by the intellectual disability gene PAK1 under homeostatic and demyelinating conditions Open
Appropriate proliferation and repopulation of oligodendrocyte progenitor cells (OPCs) determine successful (re)myelination in homeostatic and demyelinating brains. Activating mutations in p21-activated kinase 1 (PAK1) cause intellectual di…
View article: Identifying and targeting key driver genes for collagen production within the 11q13/14 breast cancer amplicon
Identifying and targeting key driver genes for collagen production within the 11q13/14 breast cancer amplicon Open
Genetic studies indicate that breast cancer can be divided into several basic molecular groups. One of these groups, termed IntClust-2, is characterized by amplification of a small portion of chromosome 11 and has a median survival of only…
View article: KRAS mutation-selective requirement for ACSS2 in colorectal adenoma formation.
KRAS mutation-selective requirement for ACSS2 in colorectal adenoma formation. Open
Oncogenic KRAS mutations are prevalent in colorectal cancer (CRC) and are associated with poor prognosis and resistance to therapy. There is a substantial diversity of KRAS mutant alleles observed in CRC. Emerging clinical and experimental…
View article: PAK2 is necessary for myelination in the peripheral nervous system
PAK2 is necessary for myelination in the peripheral nervous system Open
Myelination enables electrical impulses to propagate on axons at the highest speed, encoding essential life functions. The Rho family GTPases, RAC1 and CDC42, have been shown to critically regulate Schwann cell myelination. P21-activated k…
View article: A PTP1B-Cdk3 Signaling Axis Promotes Cell Cycle Progression of Human Glioblastoma Cells through an Rb-E2F Dependent Pathway
A PTP1B-Cdk3 Signaling Axis Promotes Cell Cycle Progression of Human Glioblastoma Cells through an Rb-E2F Dependent Pathway Open
PTP1B plays a key role in developing different types of cancer. However, the molecular mechanism underlying this effect is unclear. To identify molecular targets of PTP1B that mediate its role in tumorigenesis, we undertook a SILAC-based p…
View article: Expression of Concern: α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini
Expression of Concern: α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini Open
There are potential issues in J. Cell Sci. (2007) 120, 3700-3712 (doi:10.1242/jcs.03484).A duplication of the control blots in Figs 2A and 4A and an area of possible overlap between the PID/Control panel in Fig. 6C and the NFκB p65/Control…
View article: The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation
The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation Open
Stringent control of centrosome duplication and separation is important for preventing chromosome instability. Structural and numerical alterations in centrosomes are hallmarks of neoplastic cells and contribute to tumorigenesis. We show t…
View article: Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints Open
RAC1 P29S is the third most prevalent hotspot mutation in sun-exposed melanoma. RAC1 alterations in cancer are correlated with poor prognosis, resistance to standard chemotherapy, and insensitivity to targeted inhibitors. Although RAC1P2…
View article: Unique vulnerability of<i>RAC1</i>-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
Unique vulnerability of<i>RAC1</i>-mutant melanoma to combined inhibition of CDK9 and immune checkpoints Open
RAC1 P29S is the third most prevalent hotspot mutation in sun-exposed melanoma. RAC1 alterations in cancer are correlated with poor prognosis, resistance to standard chemotherapy, and insensitivity to targeted inhibitors. Although RAC1 P29…
View article: Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation
Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation Open
Dysregulated Interleukin (IL)-17 expression and its downstream signaling is strongly linked to inflammatory bowel diseases (IBD). However, the molecular mechanisms by which the function of RORγt, the transcription factor of IL-17, is regul…
View article: Targeting P21-Activated Kinase-1 for Metastatic Prostate Cancer
Targeting P21-Activated Kinase-1 for Metastatic Prostate Cancer Open
Metastatic prostate cancer (mPCa) has limited therapeutic options and a high mortality rate. The p21-activated kinase (PAK) family of proteins is important in cell survival, proliferation, and motility in physiology, and pathologies such a…
View article: Supplementary Figure 1 from Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival through the AKT1 and Raf–MAPK Pathways
Supplementary Figure 1 from Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival through the AKT1 and Raf–MAPK Pathways Open
PDF file - 48K, 2-dimensional immunoblot analysis of PAK1, PAK1/2/3 and P PAK1/2/3 levels in four different human MM cell lines
View article: Supplementary Data from Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of <i>Nf2</i>-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling
Supplementary Data from Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of <i>Nf2</i>-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling Open
Supplementary Data from Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling
View article: Supplementary Figure 5 from Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival through the AKT1 and Raf–MAPK Pathways
Supplementary Figure 5 from Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival through the AKT1 and Raf–MAPK Pathways Open
PDF file - 18K, MTS assays of ME12 and Meso 22 cells treated with 0, 10, 20, 30, 40, 50, 60 and 70 muM PIR3.5 compound after 72 hours of treatment
View article: Data from Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of <i>Nf2</i>-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling
Data from Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of <i>Nf2</i>-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling Open
Because loss of the NF2 tumor suppressor gene results in p21-activated kinase (Pak) activation, PAK inhibitors hold promise for the treatment of NF2-deficient tumors. To test this possibility, we asked if loss of Pak2, a highly expressed g…