Jonathan R. Clark
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View article: Circulating tumor cells predict relapse in head and neck mucosal squamous cell carcinoma
Circulating tumor cells predict relapse in head and neck mucosal squamous cell carcinoma Open
CTCs detected using the AccuCyte-CyteFinder platform demonstrate independent prognostic value in HNmSCC patients, complementing conventional pathologic assessment, particularly margin involvement. This proof-of-concept study provides preli…
View article: Deep tissue sequencing improves genetic diagnostic yield in focal cortical dysplasia
Deep tissue sequencing improves genetic diagnostic yield in focal cortical dysplasia Open
Focal cortical dysplasias (FCDs) are malformations of cortical development associated with drug-resistant focal epilepsy. We analysed surgical tissue from 28 consecutive cases recruited from adult and pediatric epilepsy surgery programs. W…
View article: Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma
Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma Open
Precision medicine is a likely future for all cancer treatment but may have its greatest impact on less common, high-mortality, and molecularly heterogeneous cancers. TFCP2-rearranged rhabdomyosarcoma (RMS) is a rare, aggressive cancer wit…
View article: In Silico Modeling of Safe Force Limits for Trismus Therapy Following Jaw Reconstruction
In Silico Modeling of Safe Force Limits for Trismus Therapy Following Jaw Reconstruction Open
Background and Objective Restricted mouth opening (trismus) is a common complication following segmental mandibulectomy and autologous bone reconstruction. However, the biomechanical limits of reconstructed mandibles, particularly in cases…
View article: CTCF Binding Site Mutations: Linking Topologically Associated Domains Dysregulation to Cutaneous Squamous Cell Carcinoma Progression
CTCF Binding Site Mutations: Linking Topologically Associated Domains Dysregulation to Cutaneous Squamous Cell Carcinoma Progression Open
Background Cutaneous squamous cell carcinoma (cSCC) is the most common lethal malignancy with metastatic potential. The high mutational burden in cSCC has made it difficult to understand the significance of variants in the noncoding and re…
View article: Improving genetic diagnostic yield in familial and sporadic cerebral cavernous malformations: detection of copy number and deep Intronic variants
Improving genetic diagnostic yield in familial and sporadic cerebral cavernous malformations: detection of copy number and deep Intronic variants Open
Cerebral cavernous malformations (CCMs) are intracranial vascular lesions associated with risk of haemorrhages and seizures. While the majority are sporadic and often associated with somatic variants in PIK3CA and MAP3K3, around 20% are fa…
View article: Traffic Light Coding System for Engaging With <scp>AI</scp> in Surgery
Traffic Light Coding System for Engaging With <span>AI</span> in Surgery Open
Artificial Intelligence (AI) is generally defined as the development of computer systems or machines that can perform tasks typically requiring human intelligence and is increasingly being used in modern healthcare. While, various AI syste…
View article: Surgical approach to model facial nerve paralysis in an ovine model for in vivo testing of a novel intervention
Surgical approach to model facial nerve paralysis in an ovine model for in vivo testing of a novel intervention Open
Facial nerve paralysis (FNP) disrupts neural inputs to the facial muscles, the most significant being those responsible for blinking. This loss often results in discomfort, corneal exposure, and if improperly treated, vision loss. FNP typi…
View article: Mechanobiologically-optimized non-resorbable artificial bone – a new paradigm in patient-matched scaffold-guided bone regeneration
Mechanobiologically-optimized non-resorbable artificial bone – a new paradigm in patient-matched scaffold-guided bone regeneration Open
Patient-matched scaffold guided bone regeneration (SGBR) has been poised to revolutionize the management of critical-sized bone defects due to trauma, tumors, infection, and congenital deformities. However, translation has been hampered by…
View article: A review of submandibular gland extirpation in an Australian quaternary referral centre: aetiologies and trends over 35 years
A review of submandibular gland extirpation in an Australian quaternary referral centre: aetiologies and trends over 35 years Open
Background Submandibular gland pathology is common but rarely reported. This study was performed to evaluate demographic, pathological, and survival outcomes associated with submandibular gland extirpation. Methods Retrospective analysis o…
View article: A comparison of the accuracy and feasibility of a low‐cost mobile application versus higher‐cost handheld <scp>3D</scp> scanner for digital ear prosthetics
A comparison of the accuracy and feasibility of a low‐cost mobile application versus higher‐cost handheld <span>3D</span> scanner for digital ear prosthetics Open
Background Facial prosthetics are an important means to rehabilitate patients with congenital or acquired facial defects. However, with a time‐consuming manual workflow and workforce shortage, access to facial prosthetics is limited in Aus…
View article: The Impact of Preoperative Facial Nerve Weakness and Facial Nerve Outcomes in the Management of Patients With Parotid Metastases of Cutaneous Squamous Cell Carcinoma
The Impact of Preoperative Facial Nerve Weakness and Facial Nerve Outcomes in the Management of Patients With Parotid Metastases of Cutaneous Squamous Cell Carcinoma Open
Background Cutaneous squamous cell carcinomas (cSCC) metastasizing to the parotid gland can cause facial nerve (FN) dysfunction secondary to direct invasion, perineural spread, or surgical ablation. This study aims to characterize the prev…
View article: Zygomatic Implant Perforated Flap vs Fibula Osseous Flap Maxillary Reconstruction
Zygomatic Implant Perforated Flap vs Fibula Osseous Flap Maxillary Reconstruction Open
This cohort study assesses the potential differences in facial contour and patient-reported outcomes in zygomatic implant perforated flap compared to fibula free flap maxillary reconstruction.
View article: Exploring Trismus Management in Australia: A Mixed Methods Evaluation of Surveys and Interviews With Health Professionals
Exploring Trismus Management in Australia: A Mixed Methods Evaluation of Surveys and Interviews With Health Professionals Open
Objective This study evaluates how health care professionals manage trismus in Australia and identifies facilitators and barriers experienced by clinicians in routine patient care. Methods A mixed‐methods approach was used to evaluate the …
View article: Determinants of Prognosis in Head and Neck Cutaneous Squamous Cell Carcinoma With Nodal Metastases
Determinants of Prognosis in Head and Neck Cutaneous Squamous Cell Carcinoma With Nodal Metastases Open
Importance The eighth edition tumor, node, metastasis (TNM) staging for head and neck cutaneous squamous cell carcinoma (HNcSCC) is a poor predictor of survival in patients with lymph node metastases, possibly due to the inclusion of extra…
View article: Jaw in a day surgery: early experience with 19 patients at an Australian tertiary referral center
Jaw in a day surgery: early experience with 19 patients at an Australian tertiary referral center Open
Background The Jaw‐in‐a‐Day (JIAD) procedure aims to achieve immediate functional occlusion via a single‐stage approach to maxillofacial reconstruction. While JIAD has gained popularity since its inception by Levine and colleagues, efficac…
View article: Botulinum toxin application to the buccinator muscle in the treatment of facial synkinesis: a prospective cohort study
Botulinum toxin application to the buccinator muscle in the treatment of facial synkinesis: a prospective cohort study Open
Background: Synkinesis may develop following facial nerve palsy, impacting quality of life. Botulinum toxin treatment for synkinesis is commonly used, but buccinator muscle injection is less common. We aim to investigate buccinator botulin…
View article: The prevalence and predictors of discharge opioid overprescribing in opioid-naïve patients after breast, gynecologic, and head and neck cancer surgery: a prospective cohort study
The prevalence and predictors of discharge opioid overprescribing in opioid-naïve patients after breast, gynecologic, and head and neck cancer surgery: a prospective cohort study Open
Our study shows that the majority of recruited patients undergoing breast, gynecologic, or head and neck cancer surgery were overprescribed opioids. Individualized assessments on patients' 24-hr opioid requirements before discharge and sup…
View article: Predictors of distant metastatic recurrence in head and neck cutaneous squamous cell carcinoma with lymph node metastases treated with curative intent: A multicenter study
Predictors of distant metastatic recurrence in head and neck cutaneous squamous cell carcinoma with lymph node metastases treated with curative intent: A multicenter study Open
Background We aimed to identify predictors of distant metastatic recurrence (DMR) in patients with head and neck cutaneous squamous cell carcinoma (HNcSCC) with nodal metastases treated with curative intent. Methods Predictors of DMR were …
View article: A qualitative exploration of the pathway to diagnosis and treatment of cutaneous squamous cell carcinoma of the head and neck with perineural spread
A qualitative exploration of the pathway to diagnosis and treatment of cutaneous squamous cell carcinoma of the head and neck with perineural spread Open
Background Perineural spread (PNS) is associated with a poor prognosis in cutaneous squamous cell carcinoma of the head and neck (cSCCHN). Hence, investigating facilitators and barriers of early diagnosis and treatment of PNS in cSCCHN may…
View article: Models of survivorship care in patients with head and neck cancer in regional, rural, and remote areas: a systematic review
Models of survivorship care in patients with head and neck cancer in regional, rural, and remote areas: a systematic review Open
Purpose Rural people with head and neck cancers (HNC) are likely to experience poorer health outcomes due to limited access to health services, so many benefit from models of care that account for rurality. The aim of this review was to sy…
View article: What is the force required to treat trismus in patients undergoing oral cavity free flap reconstruction?
What is the force required to treat trismus in patients undergoing oral cavity free flap reconstruction? Open
Background Trismus therapy is often delayed after jaw reconstruction to avoid hardware failure or non‐union. The aim of this study is to document the forces that have been applied to patients undergoing free flap reconstruction of the oral…
View article: Systematic review of adherence to swallow and trismus exercises during radiation therapy for head and neck cancer
Systematic review of adherence to swallow and trismus exercises during radiation therapy for head and neck cancer Open
Understanding the barriers and facilitators for prophylactic swallowing and trismus exercises for patients undergoing radiation to the head and neck may help exercise adherence. The analysis reviews all published reports of exercise adhere…