Jonathan Cornford
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View article: Learning From the Past with Cascading Eligibility Traces
Learning From the Past with Cascading Eligibility Traces Open
Animals often receive information about errors and rewards after a significant delay. For example, there is typically a delay of tens to hundreds of milliseconds between motor actions and visual feedback. The standard approach to handling …
View article: Brain-like learning with exponentiated gradients
Brain-like learning with exponentiated gradients Open
Computational neuroscience relies on gradient descent (GD) for training artificial neural network (ANN) models of the brain. The advantage of GD is that it is effective at learning difficult tasks. However, it produces ANNs that are a poor…
View article: How connectivity structure shapes rich and lazy learning in neural circuits.
How connectivity structure shapes rich and lazy learning in neural circuits. Open
In theoretical neuroscience, recent work leverages deep learning tools to explore how some network attributes critically influence its learning dynamics. Notably, initial weight distributions with small (resp. large) variance may yield a r…
View article: How connectivity structure shapes rich and lazy learning in neural circuits
How connectivity structure shapes rich and lazy learning in neural circuits Open
In theoretical neuroscience, recent work leverages deep learning tools to explore how some network attributes critically influence its learning dynamics. Notably, initial weight distributions with small (resp. large) variance may yield a r…
View article: Learning better with Dale’s Law: A Spectral Perspective
Learning better with Dale’s Law: A Spectral Perspective Open
Most recurrent neural networks (RNNs) do not include a fundamental constraint of real neural circuits: Dale’s Law, which implies that neurons must be excitatory (E) or inhibitory (I). Dale’s Law is generally absent from RNNs because simply…
View article: Synaptic Weight Distributions Depend on the Geometry of Plasticity
Synaptic Weight Distributions Depend on the Geometry of Plasticity Open
A growing literature in computational neuroscience leverages gradient descent and learning algorithms that approximate it to study synaptic plasticity in the brain. However, the vast majority of this work ignores a critical underlying assu…
View article: Long‐term potentiation in neurogliaform interneurons modulates excitation–inhibition balance in the temporoammonic pathway
Long‐term potentiation in neurogliaform interneurons modulates excitation–inhibition balance in the temporoammonic pathway Open
Apical dendrites of pyramidal neurons integrate information from higher‐order cortex and thalamus, and gate signalling and plasticity at proximal synapses. In the hippocampus, neurogliaform cells and other interneurons located within strat…
View article: Learning to live with Dale’s principle: ANNs with separate excitatory and inhibitory units
Learning to live with Dale’s principle: ANNs with separate excitatory and inhibitory units Open
A bstract The units in artificial neural networks (ANNs) can be thought of as abstractions of biological neurons, and ANNs are increasingly used in neuroscience research. However, there are many important differences between ANN units and …
View article: In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy
In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy Open
Epilepsy is a major health burden, calling for new mechanistic insights and therapies. CRISPR-mediated gene editing shows promise to cure genetic pathologies, although hitherto it has mostly been applied ex vivo. Its translational potentia…
View article: Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies
Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies Open
Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing. The importance of fast synaptic recruitment and action potential initiati…
View article: Epilepsy Gene Therapy Using an Engineered Potassium Channel
Epilepsy Gene Therapy Using an Engineered Potassium Channel Open
Refractory focal epilepsy is a devastating disease for which there is frequently no effective treatment. Gene therapy represents a promising alternative, but treating epilepsy in this way involves irreversible changes to brain tissue, so v…
View article: Long-term potentiation in neurogliaform cells modulates excitation-inhibition balance in the temporoammonic pathway
Long-term potentiation in neurogliaform cells modulates excitation-inhibition balance in the temporoammonic pathway Open
Apical dendrites of pyramidal neurons integrate information from higher-order cortex and thalamus, and gate signaling and plasticity at proximal synapses. In the hippocampus, neurogliaform cells and other interneurons located within stratu…
View article: <i>In vivo</i>CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy
<i>In vivo</i>CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy Open
Epilepsy is a major health burden, calling for new mechanistic and therapeutic insights. CRISPR–mediated gene editing shows promise to cure genetic pathologies, although hitherto it has mostly been applied ex-vivo . Its translational poten…
View article: KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition Open
Although cortical interneurons are apparently well-placed to suppress seizures, several recent reports have highlighted a paradoxical role of parvalbumin-positive perisomatic-targeting (PV+) interneurons in ictogenesis. Here, we use an acu…
View article: Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies
Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies Open
Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing. The importance of fast synaptic recruitment, action potential initiation …