Jonathan D. Hafferty
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View article: A service evaluation of passive remote monitoring technology for patients in a high-secure forensic psychiatric hospital: a qualitative study
A service evaluation of passive remote monitoring technology for patients in a high-secure forensic psychiatric hospital: a qualitative study Open
View article: A service evaluation of non-contact vision-based patient monitoring technology for patients in a high-secure forensic psychiatric hospital: a qualitative study
A service evaluation of non-contact vision-based patient monitoring technology for patients in a high-secure forensic psychiatric hospital: a qualitative study Open
Background Technology has the potential to monitor patient safety in real-time that helps staff and without disturbing the patient. However, staff and patients’ perspectives on using passive monitoring within an inpatient setting is lackin…
View article: GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors
GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors Open
This multi-ancestry analysis of suicide attempt identified several loci contributing to risk and establishes significant shared genetic covariation with clinical phenotypes. These findings provide insight into genetic factors associated wi…
View article: Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors
Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors Open
Objective Suicidal behavior is heritable and a major cause of death worldwide. Two large-scale genome-wide association studies (GWAS) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The …
View article: Incels, violence and mental disorder: a narrative review with recommendations for best practice in risk assessment and clinical intervention
Incels, violence and mental disorder: a narrative review with recommendations for best practice in risk assessment and clinical intervention Open
SUMMARY In recent years, mass violence associated with men who identify as involuntary celibates (incels) has been of increasing concern. Incels engage in an online community where misogyny and incitements to violence against women are pre…
View article: Olanzapine long-acting injection, discontinuation rates and reasons for discontinuation: 10 years’ experience at a UK high-secure hospital
Olanzapine long-acting injection, discontinuation rates and reasons for discontinuation: 10 years’ experience at a UK high-secure hospital Open
Background: Olanzapine pamoate has been shown to be an effective second-generation long-acting injection. Its popularity has possibly been adversely affected by the rare incidence of post-injection syndrome (PIS) and the associated require…
View article: Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors Open
View article: Quantifying psychotropic treatment and illness outcome in cohort studies using record-linkage to administrative health data
Quantifying psychotropic treatment and illness outcome in cohort studies using record-linkage to administrative health data Open
The advent of powerful information technology and the increasing availability of socalled ‘Big Data’, in a multitude of forms, has had revolutionary impact on many aspects of society, such as commerce and communication. Within healthcare b…
View article: Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments
Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments Open
STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on…
View article: DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan Open
DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide associ…
View article: Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors
Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors Open
Suicide is a leading cause of death worldwide and non-fatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both are known to have a substantial genetic etiology, which is…
View article: Birth weight associations with DNA methylation differences in an adult population
Birth weight associations with DNA methylation differences in an adult population Open
The Developmental Origins of Health and Disease (DOHaD) theory predicts that prenatal and early life events shape adult health outcomes. Birth weight is a useful indicator of the foetal experience and has been associated with multiple adul…
View article: DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan Open
DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide associ…
View article: Genome-wide association summary statistics of antidepressant treatment resistance meta-analysis
Genome-wide association summary statistics of antidepressant treatment resistance meta-analysis Open
Data from Wigmore et al "Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP". The Pharmacogenomics Journal 20, 329–341 (202…
View article: Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments
Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments Open
STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on…
View article: Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population
Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population Open
Background The Developmental Origins of Adult Disease (DOAD) theory predicts that prenatal and early life events shape adult health outcomes. Birth weight is a useful indicator of the foetal experience, and has been associated with multipl…
View article: The role of neuroticism in self-harm and suicidal ideation: results from two UK population-based cohorts
The role of neuroticism in self-harm and suicidal ideation: results from two UK population-based cohorts Open
View article: Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions Open
View article: Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP
Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP Open
View article: How data science can advance mental health research
How data science can advance mental health research Open
View article: Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank
Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank Open
View article: Self-reported medication use validated through record linkage to national prescribing data
Self-reported medication use validated through record linkage to national prescribing data Open
View article: Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression
Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression Open
View article: Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts
Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts Open
View article: Invited Commentary on Stewart and Davis “ ‘Big data’ in mental health research—current status and emerging possibilities”
Invited Commentary on Stewart and Davis “ ‘Big data’ in mental health research—current status and emerging possibilities” Open
View article: Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression
Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression Open
Background Both genetic and environmental contributions to risk of depression have been identified, but estimates of their effects are limited. Commonalities between major depressive disorder (MDD) and self-declared depression (SDD) are al…
View article: Cognitive Apprenticeship in Clinical Practice; Can it be Extended to Postgraduate Psychiatry Training Programmes?
Cognitive Apprenticeship in Clinical Practice; Can it be Extended to Postgraduate Psychiatry Training Programmes? Open
Introduction: Postgraduate psychiatry training occurs in the workplace or situated learning settings. The Cognitive Apprenticeship Model [CAM] was introduced as an instructional model for situated learning. While undergraduate medical stud…
View article: Dissection of Major Depressive Disorder using polygenic risk scores for Schizophrenia in two independent cohort
Dissection of Major Depressive Disorder using polygenic risk scores for Schizophrenia in two independent cohort Open
Major depressive disorder (MDD) is known for its substantial clinical and suspected causal heterogeneity. It is characterised by low mood, psychomotor slowing, and increased levels of the personality trait neuroticism; factors which are al…