Jonathan D. Lee
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View article: Age-dependent transcriptomic effects of morphine in the frontal cortex of female mice
Age-dependent transcriptomic effects of morphine in the frontal cortex of female mice Open
Increasing lifespans make health problems in the elderly such as opioid misuse a more prominent concern. Understanding the effects that opioids may have on the aged brain can help us address age-related concerns of opioid exposure. This st…
View article: EGFR-induced lncRNA <i>TRIDENT</i> promotes drug resistance in non–small cell lung cancer via phospho-TRIM28-mediated DNA damage repair
EGFR-induced lncRNA <i>TRIDENT</i> promotes drug resistance in non–small cell lung cancer via phospho-TRIM28-mediated DNA damage repair Open
Long noncoding RNAs (lncRNAs) play numerous roles in cellular biology and alterations in lncRNA expression profiles have been implicated in a variety of cancers. Here, we identify and characterize a lncRNA, TRIM28 Interacting DNA damage re…
View article: Cognition-associated long noncoding RNAs are dysregulated upon severe COVID-19
Cognition-associated long noncoding RNAs are dysregulated upon severe COVID-19 Open
Severe COVID-19 leads to widespread transcriptomic changes in the human brain, mimicking diminished cognitive performance. As long noncoding RNAs (lncRNAs) play crucial roles in the regulation of gene expression, identification of the lncR…
View article: Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53 Open
COVID-19 remains a significant public health threat due to the ability of SARS-CoV-2 variants to evade the immune system and cause breakthrough infections. Although pathogenic coronaviruses such as SARS-CoV-2 and MERS-CoV lead to severe re…
View article: The conserved <scp>microRNA</scp>‐229 family controls low‐insulin signaling and dietary restriction induced longevity through interactions with <scp>SKN</scp>‐1/<scp>NRF2</scp>
The conserved <span>microRNA</span>‐229 family controls low‐insulin signaling and dietary restriction induced longevity through interactions with <span>SKN</span>‐1/<span>NRF2</span> Open
Several microRNAs have emerged as regulators of pathways that control aging. For example, miR‐228 is required for normal lifespan and dietary restriction (DR) mediated longevity through interaction with PHA‐4 and SKN‐1 transcription factor…
View article: Severe COVID-19 induces molecular signatures of aging in the human brain
Severe COVID-19 induces molecular signatures of aging in the human brain Open
Coronavirus disease 2019 (COVID-19) is predominantly an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and remains a significant threat to public health. COVID-19 is accompanied by neurolog…
View article: Genetic fusions favor tumorigenesis through degron loss in oncogenes
Genetic fusions favor tumorigenesis through degron loss in oncogenes Open
Chromosomal rearrangements can generate genetic fusions composed of two distinct gene sequences, many of which have been implicated in tumorigenesis and progression. Our study proposes a model whereby oncogenic gene fusions frequently alte…
View article: Hematopoietic p53 loss cell-extrinsically defines an immune infiltrated microenvironment in leukemia and pre-leukemia
Hematopoietic p53 loss cell-extrinsically defines an immune infiltrated microenvironment in leukemia and pre-leukemia Open
TP53 is the most frequently mutated gene in human cancers. In Acute Myeloid Leukemia (AML) and Clonal Hematopoiesis of Indeterminate Potential (CHIP), it is one of several recurrent genetic alterations. Despite multiple recent therapeutic …
View article: Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci Open
Coronary artery disease (CAD) is the leading cause of mortality and morbidity, driven by both genetic and environmental risk factors. Meta-analyses of genome-wide association studies have identified >150 loci associated with CAD and myocar…
View article: Murine Model of Femoral Artery Wire Injury with Implantation of a Perivascular Drug Delivery Patch
Murine Model of Femoral Artery Wire Injury with Implantation of a Perivascular Drug Delivery Patch Open
Percutaneous interventions including balloon angioplasty and stenting have been used to restore blood flow in vessels with occlusive vascular disease. While these therapies lead to the rapid restoration of blood flow, these technologies re…