Jonathan D. Smith
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View article: Zbp1 promotes atherosclerosis and lesion necrosis in mice
Zbp1 promotes atherosclerosis and lesion necrosis in mice Open
Zbp1 is an atherosclerosis modifier gene, similar to the canonical necroptosis genes Ripk1 and Mlkl. Higher expression of Zbp1 in DBA/2 mice may play a role in this strain having the largest lesions of all strains tested in the Apoe-defici…
View article: Macrophage–Kruppel-Like Transcription Factor 6 Signaling Promotes Experimental Atherogenesis
Macrophage–Kruppel-Like Transcription Factor 6 Signaling Promotes Experimental Atherogenesis Open
View article: ATP8B1 regulates PIP2 localization and cleavage of pyroptotic executioner Gasdermin D
ATP8B1 regulates PIP2 localization and cleavage of pyroptotic executioner Gasdermin D Open
Mutations in ATP8B1 cause progressive familial intrahepatic cholestasis, with symptoms including pruritus, pancreatitis, fat malabsorption, intestinal inflammation, and failure to thrive. High-throughput studies showed interconnection betw…
View article: Characterisation of the avascular mesenchyme during digit outgrowth
Characterisation of the avascular mesenchyme during digit outgrowth Open
The avascular mesenchyme at the tip of the developing digit contributes to digit outgrowth and patterning, however, it has been poorly characterised. Using newly developed fate mapping approaches, tissue manipulation and single-cell mRNA s…
View article: Characterisation of the Avascular Mesenchyme during Digit Outgrowth
Characterisation of the Avascular Mesenchyme during Digit Outgrowth Open
The avascular mesenchyme at the tip of the developing digit contributes to digit outgrowth and patterning, however, it has been poorly characterised. Using newly developed fate mapping approaches, tissue manipulation and single-cell mRNA s…
View article: Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk Open
View article: Optimized Method to Generate Well-Characterized Macrophages from Induced Pluripotent Stem Cells
Optimized Method to Generate Well-Characterized Macrophages from Induced Pluripotent Stem Cells Open
Background/Objectives: Macrophages play a pivotal role in various pathogenic processes, necessitating the development of efficient differentiation techniques to meet the high demand for these cells in research and therapy. Human macrophage…
View article: Upstream targeting for the prevention of atrial fibrillation: Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF)—rationale and study design
Upstream targeting for the prevention of atrial fibrillation: Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF)—rationale and study design Open
URL: https://clinicaltrials.gov/ ; Unique Identifier: NCT03603912.
View article: Transcriptomic Insights into the Atrial Fibrillation Susceptibility Locus near the MYOZ1 and SYNPO2L Genes
Transcriptomic Insights into the Atrial Fibrillation Susceptibility Locus near the MYOZ1 and SYNPO2L Genes Open
Genome-wide association studies have identified a locus on chromosome 10q22, where many co-inherited single nucleotide polymorphisms (SNPs) are associated with atrial fibrillation (AF). This study seeks to identify the impact of this locus…
View article: A novel anti-FGFR1 monoclonal antibody OM-RCA-01 exhibits potent antitumor activity and enhances the efficacy of immune checkpoint inhibitors in lung cancer models
A novel anti-FGFR1 monoclonal antibody OM-RCA-01 exhibits potent antitumor activity and enhances the efficacy of immune checkpoint inhibitors in lung cancer models Open
View article: Predicting quantum materials properties using novel faithful machine learning embeddings
Predicting quantum materials properties using novel faithful machine learning embeddings Open
Machine Learning (ML) is accelerating the progress of materials prediction and classification, with particular success in CGNN designs. While classical ML methods remain accessible, advanced deep networks are still challenging to build and…
View article: Insights into digit evolution from a fate map study of the forearm using <i>Chameleon</i>, a new transgenic chicken line
Insights into digit evolution from a fate map study of the forearm using <i>Chameleon</i>, a new transgenic chicken line Open
The cellular and genetic networks that contribute to the development of the zeugopod (radius and ulna of the forearm, tibia and fibula of the leg) are not well understood, although these bones are susceptible to loss in congenital human sy…
View article: PO-04-048 FACTORS ASSOCIATED WITH NEUROCOGNITIVE FUNCTION IN PATIENTS WITH ATRIAL FIBRILLATION
PO-04-048 FACTORS ASSOCIATED WITH NEUROCOGNITIVE FUNCTION IN PATIENTS WITH ATRIAL FIBRILLATION Open
View article: Author response: Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury
Author response: Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Article and author information Metrics Abstract Recent genome-wide association…
View article: Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury
Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury Open
Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 gene and advanced liver diseases. Specifically, the common MBOAT7 variant (rs641738) associated with reduce…
View article: Disulfiram Reduces Atherosclerosis and Enhances Efferocytosis, Autophagy, and Atheroprotective Gut Microbiota in Hyperlipidemic Mice
Disulfiram Reduces Atherosclerosis and Enhances Efferocytosis, Autophagy, and Atheroprotective Gut Microbiota in Hyperlipidemic Mice Open
Background Pyroptosis executor GsdmD (gasdermin D) promotes atherosclerosis in mice and humans. Disulfiram was recently shown to potently inhibit GsdmD, but the in vivo efficacy and mechanism of disulfiram's antiatherosclerotic activity is…
View article: Reviewer #2 (Public Review): Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury
Reviewer #2 (Public Review): Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury Open
Several recent genome-wide association studies (GWAS) have identified single nucleotide polymorphism (SNPs) near the gene encoding membrane-bound O-acyltransferase 7 (MBOAT7) that is associated with advanced liver diseases. In fact, a comm…
View article: Author Response: Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury
Author Response: Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury Open
Several recent genome-wide association studies (GWAS) have identified single nucleotide polymorphism (SNPs) near the gene encoding membrane-bound O-acyltransferase 7 (MBOAT7) that is associated with advanced liver diseases. In fact, a comm…
View article: Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury
Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury Open
Several recent genome-wide association studies (GWAS) have identified single nucleotide polymorphism (SNPs) near the gene encoding membrane-bound O-acyltransferase 7 (MBOAT7) that is associated with advanced liver diseases. In fact, a comm…
View article: Artificial Sweeteners: A New Dietary Environmental Risk Factor for Atrial Fibrillation?
Artificial Sweeteners: A New Dietary Environmental Risk Factor for Atrial Fibrillation? Open
View article: Network-Based Metabolomic and Transcriptomic Analyses Identify Impaired Bcaa Catabolism Associated with Chemotherapy-Induced Heart Failure
Network-Based Metabolomic and Transcriptomic Analyses Identify Impaired Bcaa Catabolism Associated with Chemotherapy-Induced Heart Failure Open
View article: Reviewer #2 (Public Review): Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury
Reviewer #2 (Public Review): Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury Open
Several recent genome-wide association studies (GWAS) have identified single nucleotide polymorphism (SNPs) near the gene encoding membrane-bound O-acyltransferase 7 (MBOAT7) that is associated with advanced liver diseases. In fact, a comm…
View article: Reviewer #1 (Public Review): Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury
Reviewer #1 (Public Review): Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury Open
Several recent genome-wide association studies (GWAS) have identified single nucleotide polymorphism (SNPs) near the gene encoding membrane-bound O-acyltransferase 7 (MBOAT7) that is associated with advanced liver diseases. In fact, a comm…
View article: Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury
Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury Open
Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 gene and advanced liver diseases. Specifically, the common MBOAT7 variant (rs641738) associated with reduce…
View article: Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury
Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury Open
Several recent genome-wide association studies (GWAS) have identified single nucleotide polymorphism (SNPs) near the gene encoding membrane-bound O-acyltransferase 7 (MBOAT7) that is associated with advanced liver diseases. In fact, a comm…
View article: Front matter
Front matter Open
View article: Protection of Extraribosomal RPL13a by GAPDH and Dysregulation by S-Nitrosylation
Protection of Extraribosomal RPL13a by GAPDH and Dysregulation by S-Nitrosylation Open
View article: Disulfiram reduces atherosclerosis and enhances efferocytosis, autophagy, and atheroprotective gut microbiota in hyperlipidemic mice
Disulfiram reduces atherosclerosis and enhances efferocytosis, autophagy, and atheroprotective gut microbiota in hyperlipidemic mice Open
Pyroptosis executor Gasdermin (GsdmD) promotes atherosclerosis in mice and humans. Disulfiram (DSF) was recently shown to potently inhibit GsdmD, but the in-vivo efficacy and mechanism of DSF’s anti-atherosclerotic activity is yet to be ex…
View article: Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury
Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury Open
Several recent genome-wide association studies (GWAS) have identified single nucleotide polymorphism (SNPs) near the gene encoding membrane-bound O -acyltransferase 7 ( MBOAT7 ) that is associated with advanced liver diseases. In fact, a c…
View article: Connecting the Dots From GWAS to Function in Atrial Fibrillation for <i>ZFHX3</i>
Connecting the Dots From GWAS to Function in Atrial Fibrillation for <i>ZFHX3</i> Open