Jonathan D. Strope
YOU?
Author Swipe
View article: Small-molecule disruption of androgen receptor–dependent chromatin clusters
Small-molecule disruption of androgen receptor–dependent chromatin clusters Open
Sustained androgen receptor (AR) signaling during relapse is a central driver of metastatic castration-resistant prostate cancer (mCRPC). Current AR antagonists, such as enzalutamide, fail to provide long-term benefit for the mCRPC patient…
View article: Detection of Extracellular Vesicle-Derived RNA as Potential Prostate Cancer Biomarkers: Role of Cancer-type SLCO1B3 and ABCC3
Detection of Extracellular Vesicle-Derived RNA as Potential Prostate Cancer Biomarkers: Role of Cancer-type SLCO1B3 and ABCC3 Open
Extracellular vesicles (EVs) provide a minimally invasive liquid biopsy source of tumor-specific markers for patients who have already undergone prostatectomies. Our laboratory has previously demonstrated enrichment of the cancer-type solu…
View article: <i>GNRH2</i>Polymorphism in Men With Prostate Cancer Treated With Androgen Deprivation Therapy
<i>GNRH2</i>Polymorphism in Men With Prostate Cancer Treated With Androgen Deprivation Therapy Open
GNRH2 is expressed in normal, hyperplastic, and neoplastic prostate tissues; the A16V variant is not related to treatment outcome or survival.
View article: Figure S2 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S2 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S2. Ten hypoxia response elements were identified by sequence alignment of the RefSeq SLCO1B3 gene (NG_032071.1).
View article: Figure S4 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S4 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S4. Both (A) lt-SLCO1B3 and (B) ct-SLCO1B3 were plotted as a function of t-SLCO1B3 in 384 tissue and tumor samples.
View article: Table S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Table S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
Supplemental Table 1
View article: Table S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Table S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
Supplemental Table 1
View article: Figure S3 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S3 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S3. t-SLCO1B3 expression was optimized using various concentrations of chetomin at different timepoints in (A) LNCaP and (B) 22Rv1 cell lines.
View article: Figure S2 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S2 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S2. Ten hypoxia response elements were identified by sequence alignment of the RefSeq SLCO1B3 gene (NG_032071.1).
View article: Data from Antitumor Activity of NLG207 (Formerly CRLX101) in Combination with Enzalutamide in Preclinical Prostate Cancer Models
Data from Antitumor Activity of NLG207 (Formerly CRLX101) in Combination with Enzalutamide in Preclinical Prostate Cancer Models Open
Effective treatments for patients with metastatic castration-resistant prostate cancer following disease progression on enzalutamide are currently an unmet clinical need. Simultaneous inhibition of the hypoxia-inducible factor (HIF)-1α and…
View article: Supplementary Data from Antitumor Activity of NLG207 (Formerly CRLX101) in Combination with Enzalutamide in Preclinical Prostate Cancer Models
Supplementary Data from Antitumor Activity of NLG207 (Formerly CRLX101) in Combination with Enzalutamide in Preclinical Prostate Cancer Models Open
Figures S1, S2, S3, S4, and S5
View article: Supplemental Figure Legends from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Supplemental Figure Legends from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
Supplemental Figure Legends 1-4
View article: Figure S4 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S4 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S4. Both (A) lt-SLCO1B3 and (B) ct-SLCO1B3 were plotted as a function of t-SLCO1B3 in 384 tissue and tumor samples.
View article: Data from Antitumor Activity of NLG207 (Formerly CRLX101) in Combination with Enzalutamide in Preclinical Prostate Cancer Models
Data from Antitumor Activity of NLG207 (Formerly CRLX101) in Combination with Enzalutamide in Preclinical Prostate Cancer Models Open
Effective treatments for patients with metastatic castration-resistant prostate cancer following disease progression on enzalutamide are currently an unmet clinical need. Simultaneous inhibition of the hypoxia-inducible factor (HIF)-1α and…
View article: Data from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Data from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
Castration-resistant prostate cancer (CRPC) has greater intratumoral testosterone concentrations than similar tumors from eugonadal men; simple diffusion does not account for this observation. This study was undertaken to ascertain the and…
View article: Figure S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S1. Expression of (A) doxycycline-inducible GFP-linked OATP1B3 was confirmed in the membrane and not cytosolic fractions of PC3 cells using a GFP-specific antibody Abcam goat antibody (#ab6673).
View article: Supplemental Figure Legends from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Supplemental Figure Legends from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
Supplemental Figure Legends 1-4
View article: Figure S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S1. Expression of (A) doxycycline-inducible GFP-linked OATP1B3 was confirmed in the membrane and not cytosolic fractions of PC3 cells using a GFP-specific antibody Abcam goat antibody (#ab6673).
View article: Figure S3 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S3 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S3. t-SLCO1B3 expression was optimized using various concentrations of chetomin at different timepoints in (A) LNCaP and (B) 22Rv1 cell lines.
View article: Supplementary Data from Antitumor Activity of NLG207 (Formerly CRLX101) in Combination with Enzalutamide in Preclinical Prostate Cancer Models
Supplementary Data from Antitumor Activity of NLG207 (Formerly CRLX101) in Combination with Enzalutamide in Preclinical Prostate Cancer Models Open
Figures S1, S2, S3, S4, and S5
View article: Data from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Data from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
Castration-resistant prostate cancer (CRPC) has greater intratumoral testosterone concentrations than similar tumors from eugonadal men; simple diffusion does not account for this observation. This study was undertaken to ascertain the and…
View article: Biological Effects of Modifications of the Englerin A Glycolate
Biological Effects of Modifications of the Englerin A Glycolate Open
Modifications at the glycolate moiety of englerin A were made to explore variations at the most sensitive site on the molecule for activity in the NCI 60 screen, wherein englerin A is highly potent and selective for renal cancer cells. Rep…
View article: Drug-drug Interactions in Patients with HIV and Cancer in Sub-Saharan Africa
Drug-drug Interactions in Patients with HIV and Cancer in Sub-Saharan Africa Open
In Sub-Saharan Africa, the cancer burden is predicted to increase by > 85% by 2030, the largest increase worldwide. This region has a large HIV-positive population. Drug-drug interactions (DDIs) from concomitant use of multiple drugs incre…
View article: Pilot study of gadoxetate disodium-enhanced mri for localized and metastatic prostate cancers
Pilot study of gadoxetate disodium-enhanced mri for localized and metastatic prostate cancers Open
OATP1B3 is expressed de novo in primary prostate cancer tissue and to a greater degree in prostate cancer metastases. Gadoxetate disodium is a substrate of OATP1B3, and its uptake has been shown to correlate with OATP1B3 expression in othe…
View article: Antitumor Activity of NLG207 (Formerly CRLX101) in Combination with Enzalutamide in Preclinical Prostate Cancer Models
Antitumor Activity of NLG207 (Formerly CRLX101) in Combination with Enzalutamide in Preclinical Prostate Cancer Models Open
Effective treatments for patients with metastatic castration-resistant prostate cancer following disease progression on enzalutamide are currently an unmet clinical need. Simultaneous inhibition of the hypoxia-inducible factor (HIF)-1α and…
View article: On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs
On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs Open
Cereblon (CRBN), the substrate receptor of an E3 ubiquitin ligase complex, is a target of thalidomide and thalidomide-derived immunomodulatory drugs (IMiDs). The binding of these IMiDs to CRBN alters the substrate specificity of the ligase…
View article: Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition
Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition Open
Modifications at the bridgehead position of englerin A were made to explore the effects of variation at this site on the molecule for biological activity, as judged by the NCI 60 screen, in which englerin A is highly potent and selective f…
View article: Role of cereblon in angiogenesis and in mediating the antiangiogenic activity of immunomodulatory drugs
Role of cereblon in angiogenesis and in mediating the antiangiogenic activity of immunomodulatory drugs Open
Cereblon (CRBN) is a substrate recruiter element of the E3 cullin 4‐RING ubiquitin ligase complex, and a binding target of immunomodulatory agents (IMiDs). CRBN is responsible for the pleiotropic effects of IMiDs, yet its function in angio…
View article: COVID‐19 Clinical Diagnostics and Testing Technology
COVID‐19 Clinical Diagnostics and Testing Technology Open
Given the global nature of the coronavirus disease 2019 (COVID‐19) pandemic, the need for disease detection and expanding testing capacity remains critical priorities. This review discusses the technological advances in testing capability …