Jonathan D. Wren
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View article: Publisher Correction: Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases
Publisher Correction: Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases Open
View article: Methylation array signals are predictive of chronological age without bisulfite conversion
Methylation array signals are predictive of chronological age without bisulfite conversion Open
DNA methylation data has been used to make “epigenetic clocks” which attempt to measure chronological and biological aging. These models rely on data derived from bisulfite-based measurements, which exploit a semi-selective deamination and…
View article: A Non-canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver
A Non-canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver Open
Liver aging is characterized by chronic inflammation and metabolic dysfunction that contributes to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Necroptosis, a form of inflammatory cell death, is acti…
View article: Spatial transcriptomics delineates potential differences in intestinal phenotypes of cardiac and classical necrotizing enterocolitis
Spatial transcriptomics delineates potential differences in intestinal phenotypes of cardiac and classical necrotizing enterocolitis Open
View article: A satellite cell‐dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity
A satellite cell‐dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity Open
Satellite cells comprise a small proportion of mononuclear cells in adult skeletal muscle. Despite their relative rarity, satellite cells have critical functions in muscle adaptation, particularly during prolonged exercise training. The me…
View article: The toll like receptor 7 pathway and the sex bias of systemic lupus erythematosus
The toll like receptor 7 pathway and the sex bias of systemic lupus erythematosus Open
Systemic lupus erythematosus (SLE) predominately affects women with a ratio of females-to-males of about 9:1. The complement of sex chromosomes may play and important role in the mechanism of the sex bias. Previous work has shown that men …
View article: Sensory processing subtypes relate to distinct emotional and behavioral phenotypes in a mixed neurodevelopmental cohort
Sensory processing subtypes relate to distinct emotional and behavioral phenotypes in a mixed neurodevelopmental cohort Open
Children with autism and other neurodevelopmental concerns (NDC) frequently exhibit an array of sensory processing dysfunction phenotypes, posing a significant challenge their adaptive development. Additionally, these children often encoun…
View article: The nitrone compound OKN-007 delays motor neuron loss and disease progression in the G93A mouse model of amyotrophic lateral sclerosis
The nitrone compound OKN-007 delays motor neuron loss and disease progression in the G93A mouse model of amyotrophic lateral sclerosis Open
Our study investigated the therapeutic potential of OKN-007 in the SOD1 G93A mouse model of amyotrophic lateral sclerosis (ALS). The impact of OKN-007, known for its antioxidant, anti-inflammatory, and neuroprotective properties, was teste…
View article: Supplementary Table 2 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Supplementary Table 2 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
List of significantly altered transcripts from RNA Seq analysis
View article: Supplementary Data Legends from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Supplementary Data Legends from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Supplementary Figures 1 -7 and Supplementary Tables 1 - 3 legends
View article: Fig. S6 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Fig. S6 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Fig S6 shows ingenuity pathway analysis for canonical pathways and upstream regulators
View article: Fig. S4 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Fig. S4 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Fig S4 shows transcript levels of Col1a1, western blots for Desmin, a-SMA and b-tubulin, Transcript levels of TGFb
View article: Fig. S3 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Fig. S3 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Fig S3 shows flow cytometry data for CD45, gating strategy and transcript levels of CD68 and TLR4
View article: Supplementary Table 1 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Supplementary Table 1 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
List of Differentially Expressed Genes from RNA Seq analysis
View article: Fig. S5 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Fig. S5 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Figure S5 shows images of liver nodules, transcript levels of AFP
View article: Fig. S2 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Fig. S2 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Figure S2 shows body weight changes, liver weight changes, Transcript levels of Il1b and H&E staining for showing KC population
View article: Fig. S7 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Fig. S7 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Figure S7 shows western blots for p-AKT/AKT, p-S6/S6, b tubulin, p-ERK/ERK, P-p-38/p-38, b catenin, p62 and b tubulin
View article: Fig. S7 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Fig. S7 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Figure S7 shows western blots for p-AKT/AKT, p-S6/S6, b tubulin, p-ERK/ERK, P-p-38/p-38, b catenin, p62 and b tubulin
View article: Fig. S2 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Fig. S2 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Figure S2 shows body weight changes, liver weight changes, Transcript levels of Il1b and H&E staining for showing KC population
View article: Supplementary Table 3 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Supplementary Table 3 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
List of primers used for quantitative real time PCR
View article: Supplementary Table 1 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Supplementary Table 1 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
List of Differentially Expressed Genes from RNA Seq analysis
View article: Fig. S3 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Fig. S3 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Fig S3 shows flow cytometry data for CD45, gating strategy and transcript levels of CD68 and TLR4
View article: Supplementary Table 3 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Supplementary Table 3 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
List of primers used for quantitative real time PCR
View article: Supplementary Table 2 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Supplementary Table 2 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
List of significantly altered transcripts from RNA Seq analysis
View article: Fig. S1 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Fig. S1 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Figure S1 shows the experimental plan of the study, IHC staining for Ripk3, Transcript levels of Mlkl and Ripk3, Western blots for Cleaved and Total Caspase 3
View article: Fig. S6 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Fig. S6 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Fig S6 shows ingenuity pathway analysis for canonical pathways and upstream regulators
View article: Fig. S1 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Fig. S1 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Figure S1 shows the experimental plan of the study, IHC staining for Ripk3, Transcript levels of Mlkl and Ripk3, Western blots for Cleaved and Total Caspase 3
View article: Supplementary Data Legends from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Supplementary Data Legends from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Supplementary Figures 1 -7 and Supplementary Tables 1 - 3 legends
View article: Fig. S4 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Fig. S4 from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Fig S4 shows transcript levels of Col1a1, western blots for Desmin, a-SMA and b-tubulin, Transcript levels of TGFb
View article: Data from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Data from Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Open
Nonalcoholic fatty liver disease (NAFLD) is one of the etiologies that contribute to hepatocellular carcinoma (HCC), and chronic inflammation is one of the proposed mediators of HCC. Since necroptosis is a cell death pathway that induces i…