Jonathan E. Leeman
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View article: RADT-53. IMPACT OF SMALLER CLINICAL TARGET VOLUME EXPANSIONS FOR THE RADIATION TREATMENT OF NEWLY DIAGNOSED GLIOBLASTOMA
RADT-53. IMPACT OF SMALLER CLINICAL TARGET VOLUME EXPANSIONS FOR THE RADIATION TREATMENT OF NEWLY DIAGNOSED GLIOBLASTOMA Open
BACKGROUND With advances in image-guidance, there has been interest in smaller clinical target volume (CTV) expansions for radiation therapy planning in glioblastoma. We reviewed the impact of varying CTV expansion margins on patterns of r…
View article: 450 | 5‐5‐5 ABRT (ADAPTIVE BRIDGING RADIATION THERAPY)—ARTIFICIAL INTELLIGENCE ENTERS THE CAR (‐T) IN RELAPSED/REFRACTORY LARGE B‐CELL LYMPHOMA: UPDATED ANALYSIS
450 | 5‐5‐5 ABRT (ADAPTIVE BRIDGING RADIATION THERAPY)—ARTIFICIAL INTELLIGENCE ENTERS THE CAR (‐T) IN RELAPSED/REFRACTORY LARGE B‐CELL LYMPHOMA: UPDATED ANALYSIS Open
View article: Projected Prostate Cancer Incidence in the Middle East by 2050: Socioeconomic Disparities and Future Implications
Projected Prostate Cancer Incidence in the Middle East by 2050: Socioeconomic Disparities and Future Implications Open
PURPOSE Prostate cancer poses a significant public health challenge in the Middle East, with advanced-stage diagnoses and high mortality rates. However, projections regarding its future incidence are limited. The aims of this study were to…
View article: Impact of Cribriform Pattern on Progression-Free Survival After Radical Prostatectomy in Gleason Score 8-10 Prostate Cancer
Impact of Cribriform Pattern on Progression-Free Survival After Radical Prostatectomy in Gleason Score 8-10 Prostate Cancer Open
Background: Although extensive research highlights the detrimental effect of cribriform pattern 4 (CP4) on survival in non-high-risk prostate cancer (PC), its prognostic significance in high-risk PC is not well understood. Methods: The ind…
View article: Treatment Noncompletion and Shorter Radiation Regimens Among US Patients With Prostate Cancer: A Focus on Asian American and Pacific Islander Patients
Treatment Noncompletion and Shorter Radiation Regimens Among US Patients With Prostate Cancer: A Focus on Asian American and Pacific Islander Patients Open
Background Higher rates of radiation therapy (RT) noncompletion may be associated with certain demographic groups in patients with prostate cancer (PC). We examined disparities in noncompletion and receipt of shorter RT regimens among disa…
View article: Clinical Outcomes and Genomic Alterations in Gleason Score 10 Prostate Cancer
Clinical Outcomes and Genomic Alterations in Gleason Score 10 Prostate Cancer Open
Background: Gleason score (GS) 10 prostate cancer (PC) is a highly aggressive localized disease. Despite advances in treating high-risk PC, the clinical outcomes and molecular underpinnings of GS 10 remain unclear. This study aimed to dete…
View article: Prostate cancer screening in the Middle East and North Africa: a cross-sectional study on current practices
Prostate cancer screening in the Middle East and North Africa: a cross-sectional study on current practices Open
Background Prostate cancer is a substantial health concern in the Middle East and North Africa region, with many cases diagnosed at advanced stages, a high mortality to incidence ratio, and low prostate cancer awareness. This study aimed t…
View article: Adaptive Skin Radiotherapy (Asrt): Clinical Outcomes and Dosimetric Evaluation of a Novel Simplified Approach for Thoracic Mri-Guided Radiotherapy
Adaptive Skin Radiotherapy (Asrt): Clinical Outcomes and Dosimetric Evaluation of a Novel Simplified Approach for Thoracic Mri-Guided Radiotherapy Open
View article: Age-Specific Impact of Cribriform Pattern in Prostate Cancer Following Radical Prostatectomy
Age-Specific Impact of Cribriform Pattern in Prostate Cancer Following Radical Prostatectomy Open
Background: Cribriform pattern 4 (CP4) is an aggressive variant in prostate cancer linked to worse clinical outcomes, including biochemical recurrence, metastases, and prostate cancer-specific mortality. However, its prognostic significanc…
View article: Molecular Alterations Associated with Histologically Overt Stromal Response in Patients with Prostate Cancer
Molecular Alterations Associated with Histologically Overt Stromal Response in Patients with Prostate Cancer Open
Prostate cancer has substantial heterogeneity in clinical outcomes and therapeutic responses, posing challenges in predicting disease progression and tailoring treatment strategies. Recent studies have highlighted the potential prognostic …
View article: Delta radiomics to track radiation response in lung tumors receiving stereotactic magnetic resonance-guided radiotherapy
Delta radiomics to track radiation response in lung tumors receiving stereotactic magnetic resonance-guided radiotherapy Open
Our study establishes the feasibility and stability of delta radiomics analysis for MR-guided lung SBRT. Findings suggest that MR delta radiomics can capture short-term radiographic manifestations of the intra-tumoral radiation effect.
View article: Histologically Overt Stromal Response and the Risk of Progression after Radical Prostatectomy for Prostate Cancer
Histologically Overt Stromal Response and the Risk of Progression after Radical Prostatectomy for Prostate Cancer Open
Purpose: Given the variable clinical course of prostate cancer and the limitations of current prognostic factors, this study was conducted to investigate the impact of a histologically overt stromal response (HOST-response) to prostate can…
View article: Prognostic Significance of the Cribriform Pattern in Prostate Cancer: Clinical Outcomes and Genomic Alterations
Prognostic Significance of the Cribriform Pattern in Prostate Cancer: Clinical Outcomes and Genomic Alterations Open
Purpose: Given the diverse clinical progression of prostate cancer (PC) and the evolving significance of histopathological factors in its management, this study aimed to explore the impact of cribriform pattern 4 (CP4) on clinical outcomes…
View article: Magnetic resonance delta radiomics to track radiation response in lung tumors receiving stereotactic MRI-guided radiotherapy
Magnetic resonance delta radiomics to track radiation response in lung tumors receiving stereotactic MRI-guided radiotherapy Open
Introduction: Lung cancer is a leading cause of cancer-related mortality, and stereotactic body radiotherapy (SBRT) has become a standard treatment for early-stage lung cancer. However, the heterogeneous response to radiation at the tumor …
View article: Second Malignancy Probabilities in Patients With Breast Cancer Treated With Conventional Versus Hypofractionated External Beam Radiation Therapy in the Adjuvant Setting
Second Malignancy Probabilities in Patients With Breast Cancer Treated With Conventional Versus Hypofractionated External Beam Radiation Therapy in the Adjuvant Setting Open
View article: The impact of responding to patient messages with large language model assistance
The impact of responding to patient messages with large language model assistance Open
Documentation burden is a major contributor to clinician burnout, which is rising nationally and is an urgent threat to our ability to care for patients. Artificial intelligence (AI) chatbots, such as ChatGPT, could reduce clinician burden…
View article: Association between Artificial Intelligence-Derived Tumor Volume and Oncologic Outcomes for Localized Prostate Cancer Treated with Radiation Therapy
Association between Artificial Intelligence-Derived Tumor Volume and Oncologic Outcomes for Localized Prostate Cancer Treated with Radiation Therapy Open
View article: Association Between Artificial Intelligence-Derived Tumor Volume and Oncologic Outcomes for Localized Prostate Cancer Treated with Radiation Therapy
Association Between Artificial Intelligence-Derived Tumor Volume and Oncologic Outcomes for Localized Prostate Cancer Treated with Radiation Therapy Open
Background Although clinical features of multi-parametric magnetic resonance imaging (mpMRI) have been associated with biochemical recurrence in localized prostate cancer, such features are subject to inter-observer variability. Objective …
View article: Comparison of MR‐soft tissue based versus biliary stent based alignment for image guidance in pancreatic SBRT
Comparison of MR‐soft tissue based versus biliary stent based alignment for image guidance in pancreatic SBRT Open
Purpose The role of biliary stents in image‐guided localization for pancreatic cancer has been inconclusive. To date, stent accuracy has been largely evaluated against implanted fiducials on cone beam computed tomography. We aim to use mag…
View article: Synthetic CT generation for MRI-guided adaptive radiotherapy in prostate cancer
Synthetic CT generation for MRI-guided adaptive radiotherapy in prostate cancer Open
Current MRI-guided adaptive radiotherapy (MRgART) workflows require fraction-specific electron and/or mass density maps, which are created by deformable image registration (DIR) between the simulation CT images and daily MR images. Manual …
View article: Second malignancy probabilities in patients with prostate cancer treated with whole pelvis radiation therapy versus prostate only radiation therapy
Second malignancy probabilities in patients with prostate cancer treated with whole pelvis radiation therapy versus prostate only radiation therapy Open
Background Whole pelvic radiation therapy (WPRT) may improve outcomes compared with prostate only radiation therapy (PORT) in some subsets of men with prostate cancer, as in the POP‐RT trial. However, there is concern about increased risk …
View article: Magnetic Resonance–Guided Prostate Stereotactic Body Radiation Therapy With Daily Online Plan Adaptation: Results of a Prospective Phase 1 Trial and Supplemental Cohort
Magnetic Resonance–Guided Prostate Stereotactic Body Radiation Therapy With Daily Online Plan Adaptation: Results of a Prospective Phase 1 Trial and Supplemental Cohort Open
View article: Stereotactic Magnetic Resonance Guided Adaptive Radiation Therapy for Abdominopelvic Metastases
Stereotactic Magnetic Resonance Guided Adaptive Radiation Therapy for Abdominopelvic Metastases Open
View article: Could an Academic Review of Pathology Lead to Changes in Patient Care in Men With Prostate Cancer?
Could an Academic Review of Pathology Lead to Changes in Patient Care in Men With Prostate Cancer? Open
View article: Radiation Dose to the Intraprostatic Urethra Correlates Strongly With Urinary Toxicity Following Prostate SBRT: A Combined Analysis of 23 Prospective Clinical Trials
Radiation Dose to the Intraprostatic Urethra Correlates Strongly With Urinary Toxicity Following Prostate SBRT: A Combined Analysis of 23 Prospective Clinical Trials Open
View article: Clinical and Dosimetric Outcomes of MR Guided Prostate SBRT With Daily Online Plan Adaptation
Clinical and Dosimetric Outcomes of MR Guided Prostate SBRT With Daily Online Plan Adaptation Open
View article: A Prospective Clinical Trial Evaluating Stereotactic Magnetic Resonance Guided Adaptive Radiation Therapy (SMART) for Pancreatic Cancer
A Prospective Clinical Trial Evaluating Stereotactic Magnetic Resonance Guided Adaptive Radiation Therapy (SMART) for Pancreatic Cancer Open
View article: Impact of Stereotactic MR-Guided Adaptive Radiation Therapy on Early Clinical and Dosimetric Outcomes in Patients With Pancreatic Cancer
Impact of Stereotactic MR-Guided Adaptive Radiation Therapy on Early Clinical and Dosimetric Outcomes in Patients With Pancreatic Cancer Open
View article: Association Between Treatment Modality and Probability of Second Malignancy in Localized Prostate Cancer Patients
Association Between Treatment Modality and Probability of Second Malignancy in Localized Prostate Cancer Patients Open
View article: Genomic Signatures in HPV-Associated Tumors
Genomic Signatures in HPV-Associated Tumors Open
Papillomaviruses dysregulate the G1/S cell cycle transition in order to promote DNA synthesis in S phase, which is a requirement for viral replication. The human papillomaviruses (HPV) E6 and E7 oncoproteins mediate degradation of the cell…