Jonathan E. Schmitz
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View article: Expanding the Horizons of Enzybiotic Identification
Expanding the Horizons of Enzybiotic Identification Open
Recently, phage lytic enzymes (also known as endolysins or, simply, lysins) have received considerable attention as potential antibacterial agents. During the infective cycle of double-stranded DNA phage, these peptidoglycan hydrolases are…
View article: Unmasking Pathogen Traits for Chronic Colonization in Neurogenic Bladder Patients
Unmasking Pathogen Traits for Chronic Colonization in Neurogenic Bladder Patients Open
Individuals with neurogenic bladder are particularly susceptible to both chronic bacterial colonization of the bladder and urinary tract infections (UTIs). Neurogenic bladder can arise from a variety of diseases such as diabetes, spinal co…
View article: Incidence Rates of RSV‐Associated Hospitalizations Among Adults in Middle Tennessee, United States, October 2022 Through September 2023
Incidence Rates of RSV‐Associated Hospitalizations Among Adults in Middle Tennessee, United States, October 2022 Through September 2023 Open
We estimated the burden of RSV‐associated hospitalizations in US adults 1 year prior to RSV vaccine introduction. The overall annual incidence rate of RSV‐associated hospitalization was 31.47 (95% CI: 21.89–43.97) per 100,000 adults. Rates…
View article: A pooled testing strategy for enterovirus D68 to facilitate local, resource-conserving surveillance
A pooled testing strategy for enterovirus D68 to facilitate local, resource-conserving surveillance Open
Pooled testing represents a resource-conserving diagnostic strategy, and we propose enterovirus-D68 (EV-D68) as an attractive target for pooling (especially locally). To validate an RT-qPCR-based approach, retrospective pools were contrive…
View article: Symptoms, Viral Loads, and Rebound Among COVID-19 Outpatients Treated With Nirmatrelvir/Ritonavir Compared With Propensity Score–Matched Untreated Individuals
Symptoms, Viral Loads, and Rebound Among COVID-19 Outpatients Treated With Nirmatrelvir/Ritonavir Compared With Propensity Score–Matched Untreated Individuals Open
BACKGROUND: Nirmatrelvir/ritonavir (N/R) reduces severe outcomes from coronavirus disease 2019 (COVID-19); however, rebound after treatment has been reported. We compared symptom and viral dynamics in individuals with COVID-19 who complete…
View article: Household Transmission of Influenza A Viruses in 2021-2022
Household Transmission of Influenza A Viruses in 2021-2022 Open
Importance: Influenza virus infections declined globally during the COVID-19 pandemic. Loss of natural immunity from lower rates of influenza infection and documented antigenic changes in circulating viruses may have resulted in increased …
View article: P-62. RSV Immunization Uptake and Barriers to Access Among Eligible Individuals During the First Season of Availability
P-62. RSV Immunization Uptake and Barriers to Access Among Eligible Individuals During the First Season of Availability Open
Background By fall 2023, RSV immunizations to protect older adults, pregnant people, and infants were recommended in the United States. Our aim was to describe uptake of and barriers to RSV immunization among community-based individuals du…
View article: Effectiveness of mRNA COVID-19 Vaccines and Hybrid Immunity in Preventing SARS-CoV-2 Infection and Symptomatic COVID-19 Among Adults in the United States
Effectiveness of mRNA COVID-19 Vaccines and Hybrid Immunity in Preventing SARS-CoV-2 Infection and Symptomatic COVID-19 Among Adults in the United States Open
Background Understanding protection against SARS-CoV-2 infection by vaccine and hybrid immunity is important for informing public health strategies as new variants emerge. Methods We analyzed data from 3 cohort studies spanning 1 September…
View article: Novel technologies for the diagnosis of urinary tract infections
Novel technologies for the diagnosis of urinary tract infections Open
Urinary tract infections (UTIs) impose a substantial burden on patient quality of life and urine testing accounts for the majority of workload in many clinical microbiology laboratories. Traditional UTI diagnosis relies on symptoms, urinal…
View article: Effectiveness of mRNA COVID-19 vaccines and hybrid immunity in preventing SARS-CoV-2 infection and symptomatic COVID-19 among adults in the United States
Effectiveness of mRNA COVID-19 vaccines and hybrid immunity in preventing SARS-CoV-2 infection and symptomatic COVID-19 among adults in the United States Open
Background Understanding protection against SARS-CoV-2 infection by vaccine and hybrid immunity is important for informing public health strategies as new variants emerge. Methods We analyzed data from three cohort studies spanning Septemb…
View article: Reduced risk of SARS-CoV-2 infection among household contacts with recent vaccination and past COVID-19 infection: results from 2 multisite case-ascertained household transmission studies
Reduced risk of SARS-CoV-2 infection among household contacts with recent vaccination and past COVID-19 infection: results from 2 multisite case-ascertained household transmission studies Open
Households are a primary setting for the transmission of SARS-CoV-2. We examined the role of prior SARS-CoV-2 immunity on the risk of infection in household close contacts. Households in the United States with an individual who tested posi…
View article: Intra-strain colony biofilm heterogeneity in uropathogenic Escherichia coli and the effect of the NlpI lipoprotein
Intra-strain colony biofilm heterogeneity in uropathogenic Escherichia coli and the effect of the NlpI lipoprotein Open
Biofilm growth facilitates the interaction of uropathogenic Escherichia coli (UPEC) with the host environment. The extracellular polymeric substances (EPS) of UPEC biofilms are composed prominently of curli amyloid fiber and cellulo…
View article: 21 The Microbial Antibiogram as a Function of Testing Indication: Susceptibility Analysis of Escherichia coli from Symptomatic and Asymptomatic Bacteriuria Patients, 2020-2021
21 The Microbial Antibiogram as a Function of Testing Indication: Susceptibility Analysis of Escherichia coli from Symptomatic and Asymptomatic Bacteriuria Patients, 2020-2021 Open
OBJECTIVES/GOALS: Antibiograms are used to guide empiric antibiotic selection. However, it is unclear if antibiotic profiles differ between symptomatic urinary tract infections (UTIs) and asymptomatic bacteriuria (ASB). We aimed to compare…
View article: Implementing <scp>l</scp>-DNA analogs as mirrors of PCR reactant hybridization state: theoretical and practical guidelines for PCR cycle control
Implementing <span>l</span>-DNA analogs as mirrors of PCR reactant hybridization state: theoretical and practical guidelines for PCR cycle control Open
Hybridization kinetics of DNA are explored and applied to improve accuracy of annealing in sensitive PCR reactions through l -DNA hybridization-based cycling control.
View article: Internationally standardized respiratory viral load testing with limited resources: A derivative‐of‐care calibration strategy for SARS‐CoV‐2
Internationally standardized respiratory viral load testing with limited resources: A derivative‐of‐care calibration strategy for SARS‐CoV‐2 Open
Introduction SARS‐CoV‐2 has demonstrated that, in targeted circumstances, viral quantification within respiratory specimens can valuably inform patient management, as well as research. Nevertheless, the pandemic has illustrated concomitant…
View article: Survey of the infant male urobiome and genomic analysis of Actinotignum spp.
Survey of the infant male urobiome and genomic analysis of Actinotignum spp. Open
The urinary bladder harbors a community of microbes termed the urobiome, which remains understudied. In this study, we present the urobiome of healthy infant males from samples collected by transurethral catheterization. Using a combinatio…
View article: 2302. Transmissibility of SARS-CoV-2 by symptom: data from a case-ascertained household transmission study
2302. Transmissibility of SARS-CoV-2 by symptom: data from a case-ascertained household transmission study Open
Background Understanding the transmissibility of respiratory viruses by symptoms is important for public health. Methods Persons who tested positive for SARS-CoV-2 and their household contacts (HHC) were recruited from 7 US sentinel sites …
View article: 930. COVID-19 symptom and viral load rebound among individuals reporting nirmatrelvir/ritonavir use compared to propensity score matched individuals not taking COVID-19 treatment
930. COVID-19 symptom and viral load rebound among individuals reporting nirmatrelvir/ritonavir use compared to propensity score matched individuals not taking COVID-19 treatment Open
Background Nirmatrelvir/ritonavir (N/R) protects against severe outcomes after SARS-CoV-2 (SCV2) infection, but patients and studies have described symptom and viral rebound after treatment. Our aim was to compare symptom and viral traject…
View article: 925. Oseltamivir usage in community settings: data from a household transmission study
925. Oseltamivir usage in community settings: data from a household transmission study Open
Background Oseltamivir is the most common antiviral prescribed to treat influenza. There are limited data about oseltamivir receipt in uncomplicated influenza, including frequency of early discontinuation of oseltamivir. Methods Individual…
View article: 400. Predictors of Post-COVID Conditions after SARS-CoV-2 Infection in Adults Enrolled in a Multistate Household Transmission Study
400. Predictors of Post-COVID Conditions after SARS-CoV-2 Infection in Adults Enrolled in a Multistate Household Transmission Study Open
Background Severe COVID-19 predicts increased risk of Post-COVID conditions (PCC). However, the impact of mild COVID-19 in non-hospitalized patients on development of PCC is less clear. Methods We recruited individuals with mild SARS-CoV-2…
View article: 2080. Reduced risk of SARS-CoV-2 infection among household contacts with hybrid immunity from recent COVID-19 vaccination and SARS-CoV-2 infection
2080. Reduced risk of SARS-CoV-2 infection among household contacts with hybrid immunity from recent COVID-19 vaccination and SARS-CoV-2 infection Open
Background COVID-19 vaccines reduce the risk of symptomatic SARS-CoV-2 infection, but it is unclear the extent to which vaccines or prior infection reduce the risk of infection in high transmission settings like households. Methods We scre…
View article: Symptoms, Viral Loads, and Rebound Among COVID-19 Outpatients Treated With Nirmatrelvir/Ritonavir Compared With Propensity Score–Matched Untreated Individuals
Symptoms, Viral Loads, and Rebound Among COVID-19 Outpatients Treated With Nirmatrelvir/Ritonavir Compared With Propensity Score–Matched Untreated Individuals Open
Background Nirmatrelvir/ritonavir (N/R) reduces severe outcomes from coronavirus disease 2019 (COVID-19); however, rebound after treatment has been reported. We compared symptom and viral dynamics in individuals with COVID-19 who completed…
View article: Clinical Laboratory Experiences During the COVID-19 Pandemic
Clinical Laboratory Experiences During the COVID-19 Pandemic Open
View article: Circulation of Parainfluenza Virus in Nashville, Tennessee Before and During the COVID-19 Pandemic
Circulation of Parainfluenza Virus in Nashville, Tennessee Before and During the COVID-19 Pandemic Open
Background During the COVID-19 pandemic, nonpharmaceutical interventions (NPIs) were introduced and altered circulation of common respiratory viruses, including the parainfluenza viruses (PIVs). Our aim was to describe the circulation of P…
View article: Common Cold Coronaviruses Detection at an Academic Hospital Before and During COVID-19 Pandemic
Common Cold Coronaviruses Detection at an Academic Hospital Before and During COVID-19 Pandemic Open
Background Community mitigation measures implemented during the COVID-19 pandemic altered the seasonality of some respiratory viruses, including the four common cold coronaviruses (CCCs). Since these measures have been relaxed, CCCs have r…
View article: Association Between Social Vulnerability Index Theme Percentile Ranks and the Number of Respiratory Viruses Detected in People Who Underwent Multiplex Testing in Nashville, Tennessee, 2018–2022
Association Between Social Vulnerability Index Theme Percentile Ranks and the Number of Respiratory Viruses Detected in People Who Underwent Multiplex Testing in Nashville, Tennessee, 2018–2022 Open
Background The CDC/ATSDR Social Vulnerability Index (SVI)—an aggregate of 16 variables grouped under four themes—measures the relative social vulnerability of each census tract in the United States. We hypothesized that social vulnerabilit…
View article: Association Between the Neutrophil-to-Lymphocyte Ratio and Adverse Outcomes in Children Aged &lt;2 Years with Respiratory Syncytial Virus
Association Between the Neutrophil-to-Lymphocyte Ratio and Adverse Outcomes in Children Aged <2 Years with Respiratory Syncytial Virus Open
Background Respiratory syncytial virus (RSV) is a leading cause of hospitalization in children <2 years old. The neutrophil-to-lymphocyte ratio (NLR) is a readily available marker of inflammation that has been studied as a prognostic ma…
View article: Draft genomes of <i>Aspergillus nomiae</i> and <i>Aspergillus tamarii</i> isolates from human eye infections
Draft genomes of <i>Aspergillus nomiae</i> and <i>Aspergillus tamarii</i> isolates from human eye infections Open
Fungal species within the genus Aspergillus are an important cause of human diseases, including aspergillosis and keratitis. We present draft genomes of Aspergillus tamarii and A. nomiae isolated from keratitis patients in a U.S. tertiary …
View article: Changes in Transmission and Symptoms of SARS-CoV-2 in United States Households, April 2020–September 2022
Changes in Transmission and Symptoms of SARS-CoV-2 in United States Households, April 2020–September 2022 Open
Background The natural history of SARS-CoV-2 infection and transmission dynamics may have changed as SARS-CoV-2 has evolved and population immunity has shifted. Methods Household contacts, enrolled from two multi-site case-ascertained hous…
View article: The Role of Mobile Genetic Elements in Virulence Factor Carriage from Symptomatic and Asymptomatic Cases of Escherichia coli Bacteriuria
The Role of Mobile Genetic Elements in Virulence Factor Carriage from Symptomatic and Asymptomatic Cases of Escherichia coli Bacteriuria Open
Escherichia coli is the most common etiological agent of urinary tract infections (UTIs), with UTI-associated strains designated “uropathogenic” E. coli or UPEC. Across urinary strains of E. coli , the global landscape of MGEs and its rela…