Jonathan E. Shaw
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View article: Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma
Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma Open
Extracellular vesicles (EVs) are an essential signalling entity in human plasma implicated in health and disease. Still, their core protein and lipid componentry, which lie at the centre of EV form and function, remain poorly defined. Here…
View article: Effect of Empagliflozin on Whole Body, Cardiac, and Renal Sympathetic Outflows in Type 2 Diabetes
Effect of Empagliflozin on Whole Body, Cardiac, and Renal Sympathetic Outflows in Type 2 Diabetes Open
View article: The association of the age at type 2 diabetes onset with diabetes progression
The association of the age at type 2 diabetes onset with diabetes progression Open
ObjectiveTo examine whether age at type 2 diabetes onset impacts disease progression, assessed by changes in glycaemic control and clinical biomarkers during follow-up.Research Design and MethodsParticipants from the Kerala Diabetes Preven…
View article: The association of the age at type 2 diabetes onset with diabetes progression
The association of the age at type 2 diabetes onset with diabetes progression Open
ObjectiveTo examine whether age at type 2 diabetes onset impacts disease progression, assessed by changes in glycaemic control and clinical biomarkers during follow-up.Research Design and MethodsParticipants from the Kerala Diabetes Preven…
View article: <b>Incidence of type 2 diabetes with verapamil compared with other calcium channel blockers</b>
<b>Incidence of type 2 diabetes with verapamil compared with other calcium channel blockers</b> Open
Objective. Evidence that the calcium channel blocker (CCB) verapamil slows type 1 diabetes progression suggests possible preventive benefits among people at risk of type 2 diabetes. We compared type 2 diabetes incidence between users of ve…
View article: The overlooked pillars of medical education: addressing the mental health and well-being of medical school administrative staff
The overlooked pillars of medical education: addressing the mental health and well-being of medical school administrative staff Open
View article: Islet autoimmunity in young First Nations women with prediabetes and type 2 diabetes
Islet autoimmunity in young First Nations women with prediabetes and type 2 diabetes Open
The proportion of individual autoantibody positivity among younger First Nations women with prediabetes or type 2 diabetes was 9%. Islet autoantibody positivity was not associated with a distinct clinical phenotype in this group. Longitudi…
View article: Regression from prediabetes to normoglycaemia and the role of cardiometabolic risk factors on the subsequent risk of developing type 2 diabetes
Regression from prediabetes to normoglycaemia and the role of cardiometabolic risk factors on the subsequent risk of developing type 2 diabetes Open
Aims/hypothesis We aimed to investigate the association between reversion to normoglycaemia among individuals with prediabetes (fasting plasma glucose 5.6–6.9 mmol/l in the absence of other criteria for type 2 diabetes) and the subsequent …
View article: Detection and characterisation of Xpert CT/NG assay Neisseria gonorrhoeae diagnostic escape mutants, England, June 2025
Detection and characterisation of Xpert CT/NG assay Neisseria gonorrhoeae diagnostic escape mutants, England, June 2025 Open
We report the timely detection of a strain of Neisseria gonorrhoeae which was confirmed as a diagnostic escape mutant on the Cepheid Xpert CT/NG assay in England in June 2025. The reason for assay failure was a likely recombination event w…
View article: Prediabetes transitions to normoglycaemia or type 2 diabetes and associated risk factors in the Obesity, Diabetes and Cardiovascular Disease Collaboration: an individual-level pooled analysis of 19 prospective cohort studies
Prediabetes transitions to normoglycaemia or type 2 diabetes and associated risk factors in the Obesity, Diabetes and Cardiovascular Disease Collaboration: an individual-level pooled analysis of 19 prospective cohort studies Open
Deakin University Postgraduate Research Scholarship.
View article: Associations of glycaemia‐related risk factors with dementia and cognitive decline in individuals with type 2 diabetes: A systematic review and meta‐analysis
Associations of glycaemia‐related risk factors with dementia and cognitive decline in individuals with type 2 diabetes: A systematic review and meta‐analysis Open
Aims To quantify prospective associations of glycaemia‐related factors with cognitive decline and all‐cause dementia and its subtypes in people with type 2 diabetes. Methods We systematically searched Embase and MEDLINE (January 2000–Octob…
View article: Socio‐economic position and the prevalence of ten chronic diseases in Australia, 2021: a whole of population census data analysis
Socio‐economic position and the prevalence of ten chronic diseases in Australia, 2021: a whole of population census data analysis Open
Objectives To investigate differences in the prevalence of specific chronic diseases in Australia by selected measures of socio‐economic position, and by age group and sex, using representative national census population data. Study design…
View article: 2025 ADS/ANZCA/GESA/NACOS clinical practice recommendations on the peri-procedural use of GLP-1/GIP receptor agonists
2025 ADS/ANZCA/GESA/NACOS clinical practice recommendations on the peri-procedural use of GLP-1/GIP receptor agonists Open
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for the treatment of type 2 diabetes and/or obesity. The physiological actions of endogenous GLP-1, and synthetic GLP-1RAs include inhibition of gastric emptying. This ha…
View article: Testing the Limits of Machine Translation from One Book
Testing the Limits of Machine Translation from One Book Open
Current state-of-the-art models demonstrate capacity to leverage in-context learning to translate into previously unseen language contexts. Tanzer et al. [2024] utilize language materials (e.g. a grammar) to improve translation quality for…
View article: Impact of eligibility for diabetes remission on response to intensive lifestyle intervention in overweight and obese people with type 2 diabetes: The Look <scp>AHEAD</scp> trial
Impact of eligibility for diabetes remission on response to intensive lifestyle intervention in overweight and obese people with type 2 diabetes: The Look <span>AHEAD</span> trial Open
Aims To achieve remission of type 2 diabetes, resources to support intensive lifestyle intervention (ILI) are directed toward people with diabetes for whom remission is achievable, that is, people with short diabetes duration and lower HbA…
View article: Lipidomic analyses of large cohort studies define the role of lipid metabolism in bridging diet and metabolic health
Lipidomic analyses of large cohort studies define the role of lipid metabolism in bridging diet and metabolic health Open
Diet is a key factor for many diseases, yet the underlying metabolic pathways involved remain poorly understood. We analyzed data from 13,335 participants across two large Australian cohorts examining comprehensive lipidomic profiles in re…
View article: Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk prediction
Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk prediction Open
View article: Associations between obesity, physical and mental function, and low back pain intensity and disability: A 14-year population-based study
Associations between obesity, physical and mental function, and low back pain intensity and disability: A 14-year population-based study Open
View article: Association between Diabetes and Anemia: Evidence from NHANES and the UK Biobank
Association between Diabetes and Anemia: Evidence from NHANES and the UK Biobank Open
Objective: To explore the association between diabetes and anemia. Research Design and Methods: We included 9,026 and 389,616 participants from the US National Health and Nutrition Examination Surveys (NHANES) and the UK Biobank study (UKB…
View article: Artificial intelligence in chronic kidney disease management: a scoping review
Artificial intelligence in chronic kidney disease management: a scoping review Open
Rationale: Chronic kidney disease (CKD) is a major public health problem worldwide associated with cardiovascular disease, renal failure, and mortality. To effectively address this growing burden, innovative solutions to management …
View article: Trends in the incidence of young-adult-onset diabetes by diabetes type: a multi-national population-based study from an international diabetes consortium
Trends in the incidence of young-adult-onset diabetes by diabetes type: a multi-national population-based study from an international diabetes consortium Open
View article: Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants
Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants Open
View article: A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies
A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies Open
The DemNCD is the first tool to predict both dementia and multiple cardio-metabolic diseases using comprehensive risk factors and provided similar predictive accuracy to existing risk tools. It has similar predictive accuracy as tools desi…
View article: High-Intensity Interval Training for Individuals With Isolated Impaired Fasting Glucose: Protocol for a Proof-of-Concept Randomized Controlled Trial
High-Intensity Interval Training for Individuals With Isolated Impaired Fasting Glucose: Protocol for a Proof-of-Concept Randomized Controlled Trial Open
Background Standard lifestyle interventions have shown limited efficacy in preventing type 2 diabetes among individuals with isolated impaired fasting glucose (i-IFG). Hence, tailored intervention approaches are necessary for this high-ris…
View article: Risk prediction of cardiovascular disease in the Asia-Pacific region: the SCORE2 Asia-Pacific model
Risk prediction of cardiovascular disease in the Asia-Pacific region: the SCORE2 Asia-Pacific model Open
Background and Aims To improve upon the estimation of 10-year cardiovascular disease (CVD) event risk for individuals without prior CVD or diabetes mellitus in the Asia-Pacific region by systematic recalibration of the SCORE2 risk algorith…
View article: Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries
Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries Open
BACKGROUND: Meat consumption could increase the risk of type 2 diabetes. However, evidence is largely based on studies of European and North American populations, with heterogeneous analysis strategies and a greater focus on red meat than …
View article: Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries
Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries Open
View article: Trends in rates of hospitalisation for infection in people with diabetes and the general population
Trends in rates of hospitalisation for infection in people with diabetes and the general population Open
Aim To describe the trends of hospitalisation for infections in people with diabetes and in the general population. Methods People with diabetes were identified from the Australian National Diabetes Services Scheme linked to hospitalisatio…
View article: Integrated image-based deep learning and language models for primary diabetes care
Integrated image-based deep learning and language models for primary diabetes care Open
Primary diabetes care and diabetic retinopathy (DR) screening persist as major public health challenges due to a shortage of trained primary care physicians (PCPs), particularly in low-resource settings. Here, to bridge the gaps, we develo…
View article: Excess risk of injury among people with type 1 and type 2 diabetes compared to the general population.
Excess risk of injury among people with type 1 and type 2 diabetes compared to the general population. Open
Objective: To estimate the relative risk and excess hospitalisation rate for injury in people with diabetes compared to the general population. Research Design and Methods: Data were obtained from the Australian National Diabetes Services …