Jonathan Sutton
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View article: Optimising rhinoplasty outcomes in patients with thick skin
Optimising rhinoplasty outcomes in patients with thick skin Open
This nasal skin thickness scale provides a simple framework for classifying nasal skin thickness. Skin thickness helps us identify patients who would benefit from optimisation of their skin before surgery to get the best results. In this c…
View article: Modifying the severity and appearance of psoriasis using deep learning to simulate anticipated improvements during treatment
Modifying the severity and appearance of psoriasis using deep learning to simulate anticipated improvements during treatment Open
A neural network was trained to generate synthetic images of severe and moderate psoriatic plaques, after being trained on 375 photographs of patients with psoriasis taken in a clinical setting. A latent w-space vector was identified that …
View article: Pustular psoriasis of pregnancy: A rare cause of placental insufficiency
Pustular psoriasis of pregnancy: A rare cause of placental insufficiency Open
Generalised pustular psoriasis of pregnancy (GPPP) is a rare dermatosis that presents in the third trimester. It merits careful clinical assessment given the difficulty in diagnosis, impact on maternal health and association with placental…
View article: Virtual Screening Approach to Identifying a Novel and Tractable Series of<i>Pseudomonas aeruginosa</i>Elastase Inhibitors
Virtual Screening Approach to Identifying a Novel and Tractable Series of<i>Pseudomonas aeruginosa</i>Elastase Inhibitors Open
Novel therapies are required to treat chronic bacterial infections in cystic fibrosis (CF) sufferers. The most common pathogen responsible for these infections is Pseudomonas aeruginosa, which persists within the lungs of CF sufferers desp…
View article: WGS to determine the extent of <i>Clostridioides difficile</i> transmission in a high incidence setting in North Wales in 2015
WGS to determine the extent of <i>Clostridioides difficile</i> transmission in a high incidence setting in North Wales in 2015 Open
Levels of transmission detected by WGS were comparable to previously described rates in endemic settings; other explanations, such as variations in antimicrobial use, are required to explain the high levels of CDI. Cephalosporins are a ris…