Jonathan E. Valencia
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View article: Combinatorial regulatory states define cell fate diversity during embryogenesis
Combinatorial regulatory states define cell fate diversity during embryogenesis Open
Cell fate specification occurs along invariant species-specific trajectories that define the animal body plan. This process is controlled by gene regulatory networks that regulate the expression of the limited set of transcription factors …
View article: Single-cell analysis of prenatal and postnatal human cortical development
Single-cell analysis of prenatal and postnatal human cortical development Open
We analyzed >700,000 single-nucleus RNA sequencing profiles from 106 donors during prenatal and postnatal developmental stages and identified lineage-specific programs that underlie the development of specific subtypes of excitatory cortic…
View article: Single-cell analysis of prenatal and postnatal human cortical development
Single-cell analysis of prenatal and postnatal human cortical development Open
We analyze more than 700,000 single-nucleus RNA-seq profiles from 106 donors during prenatal and postnatal developmental stages and identify lineage-specific programs that underlie the development of specific subtypes of excitatory cortica…
View article: Ciliary photoreceptors in sea urchin larvae indicate pan-deuterostome cell type conservation
Ciliary photoreceptors in sea urchin larvae indicate pan-deuterostome cell type conservation Open
One of the signatures of evolutionarily related cell types is the expression of similar combinations of transcription factors in distantly related animals. Here we present evidence that sea urchin larvae possess bilateral clusters of cilia…