Jonathan E. Zuckerman
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View article: Obesity-related glomerulopathy, A growing kidney burden in the obesity pandemic
Obesity-related glomerulopathy, A growing kidney burden in the obesity pandemic Open
Obesity can cause the progression of kidney disease through hemodynamic, structural, and metabolic changes, and predispose individuals to arterio-nephrosclerosis, diabetic nephropathy, and focal segmental glomerulosclerosis (FSGS), leading…
View article: Microscopic Tubulovenous Communications in Nonneoplastic Kidneys: A Single-Center Case Series and Review of the Literature
Microscopic Tubulovenous Communications in Nonneoplastic Kidneys: A Single-Center Case Series and Review of the Literature Open
This is the largest case series exploring the clinical and histologic features associated with TVFs in the kidney. Our findings support the assertion that TVFs are associated with hematuria without glomerulonephritis and occur in the setti…
View article: What’s new in medical renal pathology 2025: Updates on podocytopathy and immunofluorescence staining in medical kidney
What’s new in medical renal pathology 2025: Updates on podocytopathy and immunofluorescence staining in medical kidney Open
Diffuse podocytopathy, including minimal change disease and primary focal segmental glomerulosclerosis, is a common cause of nephrotic syndrome in adults and children. It is increasingly recognized to be autoimmune-mediated associated with…
View article: Design and Biological Activity of a Novel Brain Penetrant Urea Compound Against Glioblastoma
Design and Biological Activity of a Novel Brain Penetrant Urea Compound Against Glioblastoma Open
Glioblastoma (GBM) remains the most lethal primary brain tumor, largely due to therapy-resistant glioma stem cells (GSCs) and the ability of non-stem cells to dedifferentiate under therapeutic pressure. We developed MXC-017, a novel urea-b…
View article: Acute Kidney Injury Secondary to Pegylated Liposomal Doxorubicin-Associated Renal-limited Thrombotic Microangiopathy
Acute Kidney Injury Secondary to Pegylated Liposomal Doxorubicin-Associated Renal-limited Thrombotic Microangiopathy Open
The emergence of pegylated liposomal doxorubicin (PLD) as a preferred treatment for various malignancies, because of its reduced cardiotoxicity compared with conventional doxorubicin, has raised significant interest. However, the associati…
View article: C3 glomerulopathy post kidney transplantation: A single center experience
C3 glomerulopathy post kidney transplantation: A single center experience Open
BACKGROUND C3 glomerulopathies (C3G) are a rare cause of kidney failure resulting from complement dysregulation. Small studies demonstrate a high rate of recurrence and poor outcomes in kidney transplantation. Treatment efficacy in this se…
View article: A Multicenter Study to Evaluate Diagnostic Accuracy by Pathologists Using the Aperio GT 450 DX in Local and Remote Viewing Stations
A Multicenter Study to Evaluate Diagnostic Accuracy by Pathologists Using the Aperio GT 450 DX in Local and Remote Viewing Stations Open
Context.— The adoption of digital pathology may enable pathologists to perform primary diagnosis in both local and remote whole slide image viewing settings, improving logistics and convenience. Objective.— To test the performance of a new…
View article: Heterogeneous Presentations of iMCD: A Single‐Institution Case Series
Heterogeneous Presentations of iMCD: A Single‐Institution Case Series Open
Background Idiopathic multicentric Castleman disease (iMCD) is a rare lymphadenopathic disorder characterized by hyperplasia of multiple lymph nodes and can be associated with a wide range of symptoms and presentations, from mild disease t…
View article: Dasatinib-induced renal (or chronic) thrombotic microangiopathy in a patient with chronic myeloid leukemia: A case report
Dasatinib-induced renal (or chronic) thrombotic microangiopathy in a patient with chronic myeloid leukemia: A case report Open
Thrombotic microangiopathy encompasses microvascular thrombosis, hemolytic anemia, thrombocytopenia, and end-organ damage. Secondary thrombotic microangiopathy can result from malignancies, autoimmune diseases, or treatments such as tyrosi…
View article: Acute kidney injury and nephrotic syndrome caused by a “magic pill”
Acute kidney injury and nephrotic syndrome caused by a “magic pill” Open
We presented a case of AIN, MCD, and IgAN associated with diclofenac masquerading as a "herbal" medicine. The cause was suggested by pathology and confirmed with high-resolution liquid chromatography mass spectrometry testing of the pills.…
View article: Kidney-Limited Microangiopathy Associated with Methionine Synthase (Cobalamin G) Deficiency in a Pediatric Patient: Case Report and Review of the Literature
Kidney-Limited Microangiopathy Associated with Methionine Synthase (Cobalamin G) Deficiency in a Pediatric Patient: Case Report and Review of the Literature Open
Thrombotic microangiopathy (TMA) is a recognized sequela of inborn errors of metabolism impacting vitamin B12 (cobalamin) synthesis. Methylmalonic aciduria and homocystinuria, cobalamin deficiency type C is a well-known etiology for TMA. T…
View article: Virtual histological staining of unlabeled autopsy tissue
Virtual histological staining of unlabeled autopsy tissue Open
Traditional histochemical staining of post-mortem samples often confronts inferior staining quality due to autolysis caused by delayed fixation of cadaver tissue, and such chemical staining procedures covering large tissue areas demand sub…
View article: Blau syndrome complicated by granulomatous tubulointerstitial nephritis and immune complex mediated glomerulonephritis: A case report and review of the literature
Blau syndrome complicated by granulomatous tubulointerstitial nephritis and immune complex mediated glomerulonephritis: A case report and review of the literature Open
Blau syndrome is a rare, autosomal dominant or de novo mutation, granulomatous, auto-inflammatory disorder classically manifesting as a triad of polyarthritis, uveitis, and dermatitis. Rarely, this disease involves visceral sites such as t…
View article: A 33-Year-Old Man with a 22-Year History of Nephrotic Syndrome Due to Minimal Change Disease Exacerbated Following a Third Dose of an mRNA SARS-CoV-2 Vaccine for COVID-19
A 33-Year-Old Man with a 22-Year History of Nephrotic Syndrome Due to Minimal Change Disease Exacerbated Following a Third Dose of an mRNA SARS-CoV-2 Vaccine for COVID-19 Open
BACKGROUND Minimal change disease is a common cause of nephrotic syndrome in adults. There are few reported cases of vaccine-related podocytopathy with nephrotic-range proteinuria in the setting of a minimal change disease history. There h…
View article: Virtual histological staining of unlabeled autopsy tissue
Virtual histological staining of unlabeled autopsy tissue Open
Histological examination is a crucial step in an autopsy; however, the traditional histochemical staining of post-mortem samples faces multiple challenges, including the inferior staining quality due to autolysis caused by delayed fixation…
View article: Non-HLA Antibodies to G Protein–coupled Receptors in Pediatric Kidney Transplant Recipients: Short- and Long-term Clinical Outcomes
Non-HLA Antibodies to G Protein–coupled Receptors in Pediatric Kidney Transplant Recipients: Short- and Long-term Clinical Outcomes Open
Background. Angiotensin II type 1 receptor antibodies (AT1R-Abs) and endothelin-type A receptor antibodies (ETAR-Abs) are G protein–coupled receptor activating autoantibodies associated with antibody-mediated rejection, vascular pathology,…
View article: Non-Full House Membranous Lupus Nephritis Represents a Clinically Distinct Subset
Non-Full House Membranous Lupus Nephritis Represents a Clinically Distinct Subset Open
Key Points Non-full house (NFH) membranous lupus nephritis (MLN) is a minor subset of all MLN cases. Patients with NFH MLN tend to be older when diagnosed with systemic lupus erythematosus, undergo first renal biopsy at an older age, and h…
View article: Sporadic Case of Heterozygous X-Linked Alport Syndrome
Sporadic Case of Heterozygous X-Linked Alport Syndrome Open
Alport syndrome is a genetically and phenotypically heterogeneous disorder that can be transmitted in an X-linked, autosomal recessive, or autosomal dominant fashion and can affect glomerular, cochlear, and ocular basement membranes. The d…
View article: Severe Polyneuropathy in Hereditary Transthyretin Amyloidosis Caused by H90D Variant
Severe Polyneuropathy in Hereditary Transthyretin Amyloidosis Caused by H90D Variant Open
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View article: COVID-19 Vaccination and New Onset Glomerular Disease: Results from the IRocGN2 International Registry
COVID-19 Vaccination and New Onset Glomerular Disease: Results from the IRocGN2 International Registry Open
Key Points IgAN and MCD are the most common de novo glomerular diseases reported after COVID-19 vaccination, particularly after mRNA vaccination. Membranous nephropathy, pauci-immune GN, and collapsing GN have also been attributed to COVID…
View article: A user-friendly tool for cloud-based whole slide image segmentation with examples from renal histopathology
A user-friendly tool for cloud-based whole slide image segmentation with examples from renal histopathology Open
Background Image-based machine learning tools hold great promise for clinical applications in pathology research. However, the ideal end-users of these computational tools (e.g., pathologists and biological scientists) often lack the progr…