Jonathan Enders
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View article: P02.03.B GLIOBLASTOMA CELL-DERIVED APLN SHOWS DIFFERENTIAL EFFECTS ON MYELOID CELL MIGRATION
P02.03.B GLIOBLASTOMA CELL-DERIVED APLN SHOWS DIFFERENTIAL EFFECTS ON MYELOID CELL MIGRATION Open
BACKGROUND The rapid progression of glioblastoma (GBM) is fostered by GBM-induced immunosuppression and by tumor-associated myeloid cells (TAMs), which massively accumulate in GBM and support glioma expansion. Hence, signaling-pathways con…
View article: Episodic pain in Fabry disease is mediated by a heat shock protein-TRPA1 axis
Episodic pain in Fabry disease is mediated by a heat shock protein-TRPA1 axis Open
Two-thirds of patients with Fabry disease suffer debilitating pain attacks triggered by exercise, fever, and exposure to environmental heat. These patients face an even greater risk of heat-related episodic pain in the face of global clima…
View article: Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity
Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity Open
Patients with Fabry disease suffer from chronic debilitating pain and peripheral sensory neuropathy with minimal treatment options, but the cellular drivers of this pain are unknown. Here, we propose a mechanism we believe to be novel in w…
View article: ATP-gated potassium channels contribute to ketogenic diet-mediated analgesia in mice
ATP-gated potassium channels contribute to ketogenic diet-mediated analgesia in mice Open
Chronic pain is a substantial health burden and options for treating chronic pain remain minimally effective. Ketogenic diets are emerging as well-tolerated, effective therapeutic strategies in preclinical models of chronic pain, especiall…
View article: ATP-Gated Potassium Channels Contribute to Ketogenic Diet-Mediated Analgesia in Mice
ATP-Gated Potassium Channels Contribute to Ketogenic Diet-Mediated Analgesia in Mice Open
Chronic pain is a substantial health burden and options for treating chronic pain remain minimally effective. Ketogenic diets are emerging as well-tolerated, effective therapeutic strategies in preclinical models of chronic pain, especiall…
View article: Ketolysis is required for the proper development and function of the somatosensory nervous system
Ketolysis is required for the proper development and function of the somatosensory nervous system Open
Ketogenic diets are emerging as protective interventions in preclinical and clinical models of somatosensory nervous system disorders. Additionally, dysregulation of succinyl-CoA 3-oxoacid CoA-transferase 1 (SCOT, encoded by Oxct1), the fa…
View article: Abnormal intraepidermal nerve fiber density in disease: A scoping review
Abnormal intraepidermal nerve fiber density in disease: A scoping review Open
Background Intraepidermal nerve fiber density (IENFD) has become an important biomarker for neuropathy diagnosis and research. The consequences of reduced IENFD can include sensory dysfunction, pain, and a significant decrease in quality o…
View article: Figure S4 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Figure S4 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression Open
Combination of AZD-4547 and PF-02341066 indicates potentiated effect in admixed cultures but not in HNSCC only inoculated tumors.
View article: Figure S2 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Figure S2 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression Open
CAF secreted HGF mediates HNSCC glycolysis.
View article: Supplemental Figure Legends from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Supplemental Figure Legends from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression Open
Legends for all supplemental figures
View article: Figure S3 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Figure S3 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression Open
Endogenous expression of bFGF in HNSCC and FGFR in CAFs.
View article: Figure S4 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Figure S4 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression Open
Combination of AZD-4547 and PF-02341066 indicates potentiated effect in admixed cultures but not in HNSCC only inoculated tumors.
View article: Data from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Data from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression Open
Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists of up to 80% cancer-associated fibroblasts (CAF). We previously repor…
View article: Data from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Data from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression Open
Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists of up to 80% cancer-associated fibroblasts (CAF). We previously repor…
View article: Figure S1 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Figure S1 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression Open
HNSCC Cells have Higher Glycolytic Capacity than CAFs and CAFs have Higher Maximal Respiration than HNSCC.
View article: Figure S2 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Figure S2 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression Open
CAF secreted HGF mediates HNSCC glycolysis.
View article: Supplemental Figure Legends from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Supplemental Figure Legends from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression Open
Legends for all supplemental figures
View article: Figure S3 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Figure S3 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression Open
Endogenous expression of bFGF in HNSCC and FGFR in CAFs.
View article: Figure S1 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Figure S1 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression Open
HNSCC Cells have Higher Glycolytic Capacity than CAFs and CAFs have Higher Maximal Respiration than HNSCC.
View article: Abnormal Intraepidermal Nerve Fiber Density in Disease: A Scoping Review
Abnormal Intraepidermal Nerve Fiber Density in Disease: A Scoping Review Open
Background Intraepidermal nerve fiber density (IENFD) has become an important biomarker for neuropathy diagnosis and research. The consequences of reduced IENFD can include sensory dysfunction, pain, and a significant decrease in quality o…
View article: Ketolysis is Required for the Proper Development and Function of the Somatosensory Nervous System
Ketolysis is Required for the Proper Development and Function of the Somatosensory Nervous System Open
Ketogenic diets are emerging as protective interventions in preclinical and clinical models of somatosensory nervous system disorders. Additionally, dysregulation of succinyl-CoA 3-oxoacid CoA-transferase 1 (SCOT, encoded by Oxct1 ), the f…
View article: Lifestyle and Dietary Modifications: Relevance in the Management of Diabetic Neuropathy
Lifestyle and Dietary Modifications: Relevance in the Management of Diabetic Neuropathy Open
As common complication of prediabetes, type I and type II diabetes, diabetic peripheral neuropathy (DPN) includes a series of sensory and motor changes associated with slow nerve conduction, nerve degeneration, gate disturbances, pain, and…
View article: Emerging Nonpharmacologic Interventions to Treat Diabetic Peripheral Neuropathy
Emerging Nonpharmacologic Interventions to Treat Diabetic Peripheral Neuropathy Open
Significance: Diabetic peripheral neuropathy (DPN), a complication of metabolic syndrome, type I and type II diabetes, leads to sensory changes that include slow nerve conduction, nerve degeneration, loss of sensation, pain, and gate distu…
View article: Ketogenic diet prevents methylglyoxal-evoked nociception by scavenging methylglyoxal
Ketogenic diet prevents methylglyoxal-evoked nociception by scavenging methylglyoxal Open
Methylglyoxal (MGO) is a reactive dicarbonyl byproduct of glycolysis implicated in a growing number of neuropathic pain conditions, including chemotherapy-induced peripheral neuropathy, diabetic peripheral neuropathy, and radiculopathy wit…
View article: A ketogenic diet reduces mechanical allodynia and improves epidermal innervation in diabetic mice
A ketogenic diet reduces mechanical allodynia and improves epidermal innervation in diabetic mice Open
Dietary interventions are promising approaches to treat pain associated with metabolic changes because they impact both metabolic and neural components contributing to painful neuropathy. Here, we tested whether consumption of a ketogenic …
View article: Occupational exposure of oropharyngeal human papillomavirus amongst otolaryngologists
Occupational exposure of oropharyngeal human papillomavirus amongst otolaryngologists Open
Objectives/Hypothesis Human papillomavirus (HPV) is a DNA virus that causes cancer in multiple sites. Although sexual activity is the primary means of oropharyngeal HPV acquisition, studies suggest HPV transmission through occupational exp…
View article: Abstract 61: ECM scaffolds to elucidate the role of Col11a1 in head and neck cancer progression
Abstract 61: ECM scaffolds to elucidate the role of Col11a1 in head and neck cancer progression Open
Cancer progression is linked to physical properties, cellular and biochemical composition of the tissue environment including the extracellular matrix (ECM). The ECM not only provides signaling cues by presenting ligands, but also plays a …
View article: Pleotropic role of RNA binding protein CELF2 in autophagy induction
Pleotropic role of RNA binding protein CELF2 in autophagy induction Open
We previously reported that ionizing radiation (IR) mediates cell death through the induction of CUGBP elav‐like family member 2 (CELF2), a tumor suppressor. CELF2 is an RNA binding protein that modulates mRNA stability and translation. Si…