Jonathan Fix
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View article: mRNA and Protein Subunit COVID-19 Vaccine Reactogenicity and the Relationship to Productivity for Healthcare Workers and First Responders
mRNA and Protein Subunit COVID-19 Vaccine Reactogenicity and the Relationship to Productivity for Healthcare Workers and First Responders Open
Objectives To compare the percentage of participants that experienced any solicited systemic reactogenicity symptom after one dose of the updated 2024–2025 adjuvanted protein-based Novavax (NVX; JN.1) or Pfizer–BioNTech mRNA (PFZ; KP.2) CO…
View article: Effectiveness of NVX-CoV2373 and BNT162b2 COVID-19 Vaccination in South Korean Adolescents
Effectiveness of NVX-CoV2373 and BNT162b2 COVID-19 Vaccination in South Korean Adolescents Open
Background and aims: Adolescents can have severe/chronic outcomes from COVID-19. Real-world data on relative vaccine effectiveness between mRNA- and protein-based vaccines are limited, and more data are needed on disease outcomes in this a…
View article: Real-world effectiveness of NVX-CoV2373 and BNT162b2 mRNA COVID-19 vaccination in South Korea
Real-world effectiveness of NVX-CoV2373 and BNT162b2 mRNA COVID-19 vaccination in South Korea Open
NVX-CoV2373 demonstrated favorable and similar effectiveness against any and severe SARS-CoV-2 infection, respectively, compared with BNT162b2, with evidence of enhanced NVX-CoV2373 durability.
View article: Real-world effectiveness of NVX-CoV2373 COVID-19 vaccine in immunocompromised individuals in South Korea
Real-world effectiveness of NVX-CoV2373 COVID-19 vaccine in immunocompromised individuals in South Korea Open
Background NVX-CoV2373 is a nanoparticle, protein-based COVID-19 vaccine. Individuals who are immunocompromised (IIC) are at high risk for infection and severe disease; however, real-world NVX-CoV2373 effectiveness data in IIC are limited.…
View article: Effectiveness of NVX-CoV2373 and BNT162b2 COVID-19 Vaccination in South Korean Adolescents
Effectiveness of NVX-CoV2373 and BNT162b2 COVID-19 Vaccination in South Korean Adolescents Open
Purpose Adolescents can have severe/chronic outcomes from COVID-19. Real-word data on relative vaccine effectiveness (rVE) between mRNA- and protein-based vaccines are limited, and more data are needed on disease outcomes in this age group…
View article: Real-world effectiveness of NVX-CoV2373 and BNT162b2 mRNA COVID-19 vaccination in South Korea
Real-world effectiveness of NVX-CoV2373 and BNT162b2 mRNA COVID-19 vaccination in South Korea Open
Objectives In February 2022, NVX-CoV2373 became available in South Korea; real-world effectiveness of multiple doses compared with mRNA-based vaccines has not been thoroughly evaluated. Methods This retrospective study identified NVX-CoV23…
View article: Relative effectiveness of homologous NVX-CoV2373 and BNT162b2 COVID-19 vaccinations in South Korea
Relative effectiveness of homologous NVX-CoV2373 and BNT162b2 COVID-19 vaccinations in South Korea Open
To estimate the relative effectiveness of NVX-CoV2373 versus BNT162b2 (Pfizer-BioNTech) in preventing SARS-CoV-2 infection and severe COVID-19 disease during the Omicron variant dominance in South Korea, we conducted a retrospective cohort…
View article: Benefit–risk assessment for the Novavax COVID-19 vaccine (NVX-CoV2373)
Benefit–risk assessment for the Novavax COVID-19 vaccine (NVX-CoV2373) Open
A benefit-risk assessment of NVX-CoV2373, a vaccine to prevent COVID-19, was conducted to determine if the benefits of vaccination outweigh the risks of myocarditis/pericarditis. This analysis used data on myocarditis/pericarditis cases ob…
View article: Systematic Review and Meta-Analysis to Estimate the Treatment Effect and Inform a Noninferiority Margin for a Phase 3 Noninferiority Trial in Uncomplicated Urogenital Gonorrhea
Systematic Review and Meta-Analysis to Estimate the Treatment Effect and Inform a Noninferiority Margin for a Phase 3 Noninferiority Trial in Uncomplicated Urogenital Gonorrhea Open
Background Active-controlled noninferiority studies are used to investigate novel agents for uncomplicated urogenital gonorrhea (uUGC) as placebo-controlled trials are unethical. A systematic literature review and meta-analysis were conduc…
View article: Predictors of Influenza and Pneumococcal Vaccination Among Participants in the Women’s Health Initiative
Predictors of Influenza and Pneumococcal Vaccination Among Participants in the Women’s Health Initiative Open
Objective: Older adults typically experience higher rates of severe disease and mortality than the general population after contracting an infectious disease. Vaccination is critical for preventing disease and severe downstream outcomes; h…
View article: Linking Emergency Medical Services and Emergency Department Data to Improve Overdose Surveillance in North Carolina
Linking Emergency Medical Services and Emergency Department Data to Improve Overdose Surveillance in North Carolina Open
Introduction Linking emergency medical services (EMS) data to emergency department (ED) data enables assessing the continuum of care and evaluating patient outcomes. We developed novel methods to enhance linkage performance and analysis of…
View article: Gender differences in respiratory health outcomes among farming cohorts around the globe: findings from the AGRICOH consortium
Gender differences in respiratory health outcomes among farming cohorts around the globe: findings from the AGRICOH consortium Open
Purpose: Respiratory hazards of farming have been identified for centuries, with little focus on gender differences. We used data from the AGRICOH consortium, a collective of prospective cohorts of agricultural workers, to assess respirato…
View article: Gender differences in respiratory health outcomes among farming cohorts around the globe: findings from the AGRICOH consortium
Gender differences in respiratory health outcomes among farming cohorts around the globe: findings from the AGRICOH consortium Open
Purpose: Respiratory hazards of farming have been identified for centuries, with little focus on gender differences. We used data from the AGRICOH consortium, a collective of prospective cohorts of agricultural workers, to assess respirato…
View article: Gender differences in respiratory health outcomes among farming cohorts around the globe: findings from the AGRICOH consortium
Gender differences in respiratory health outcomes among farming cohorts around the globe: findings from the AGRICOH consortium Open
Purpose: Respiratory hazards of farming have been identified for centuries, with little focus on gender differences. We used data from the AGRICOH consortium, a collective of prospective cohorts of agricultural workers, to assess respirato…
View article: Association between Gut Microbiome Composition and Rotavirus Vaccine Response among Nicaraguan Infants
Association between Gut Microbiome Composition and Rotavirus Vaccine Response among Nicaraguan Infants Open
Rotavirus is the leading cause of childhood deaths due to diarrhea. Although existing oral rotavirus vaccines are highly efficacious in high-income countries, these vaccines have been demonstrated to have decreased efficacy in low- and mid…
View article: Optimization of Linkage between North Carolina EMS and ED Data: EMS Naloxone Cases
Optimization of Linkage between North Carolina EMS and ED Data: EMS Naloxone Cases Open
ObjectiveTo improve linkage between North Carolina’s Emergency Medical Services (EMS) and Emergency Department (ED) data using an iterative, deterministic approach.IntroductionThe opioid overdose crisis has rapidly expanded in North Caroli…