Jonathan Gans
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View article: The heme-responsive PrrH sRNA regulates <i>Pseudomonas aeruginosa</i> pyochelin gene expression
The heme-responsive PrrH sRNA regulates <i>Pseudomonas aeruginosa</i> pyochelin gene expression Open
Pseudomonas aeruginosa is an opportunistic pathogen that requires iron for growth and virulence, yet this nutrient is sequestered by the innate immune system during infection. When iron is limiting, P. aeruginosa expresses the PrrF1 and Pr…
View article: The heme-responsive PrrH sRNA regulates<i>Pseudomonas aeruginosa</i>pyochelin gene expression
The heme-responsive PrrH sRNA regulates<i>Pseudomonas aeruginosa</i>pyochelin gene expression Open
Pseudomonas aeruginosa is an opportunistic pathogen that requires iron for growth and virulence, yet this nutrient is sequestered by the innate immune system during infection. When iron is limiting, P. aeruginosa expresses the PrrF1 and Pr…
View article: The Pseudomonas aeruginosa PrrF1 and PrrF2 Small Regulatory RNAs Promote 2-Alkyl-4-Quinolone Production through Redundant Regulation of the <i>antR</i> mRNA
The Pseudomonas aeruginosa PrrF1 and PrrF2 Small Regulatory RNAs Promote 2-Alkyl-4-Quinolone Production through Redundant Regulation of the <i>antR</i> mRNA Open
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen that requires iron for growth and virulence. Under low-iron conditions, P. aeruginosa transcribes two highly identical (95%) small regulatory RNAs (sRNAs), PrrF1 and PrrF2, …
View article: Low-Dose Oxygen Enhances Macrophage-Derived Bacterial Clearance following Cigarette Smoke Exposure
Low-Dose Oxygen Enhances Macrophage-Derived Bacterial Clearance following Cigarette Smoke Exposure Open
Background. Chronic obstructive pulmonary disease (COPD) is a common, smoking-related lung disease. Patients with COPD frequently suffer disease exacerbations induced by bacterial respiratory infections, suggestive of impaired innate immun…