Jonathan Gear
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View article: A validation protocol for <sup>177</sup>Lu-SPECT image quantification as a basis for multi-centre kidney dosimetry
A validation protocol for <sup>177</sup>Lu-SPECT image quantification as a basis for multi-centre kidney dosimetry Open
Objective . Multicentre studies in molecular radiotherapy face challenges in ensuring the comparability of dosimetry results. The aim of this study was to develop a validation protocol to achieve equivalent 177 Lu-SPECT quantification acro…
View article: Nearly double the patients and dramatic changes over 14 years of UK MRT: Internal Dosimetry Users Group survey results from 2007 to 2021
Nearly double the patients and dramatic changes over 14 years of UK MRT: Internal Dosimetry Users Group survey results from 2007 to 2021 Open
Introduction The Internal Dosimetry Users Group has regularly surveyed UK molecular radiotherapy (MRT) activity in the UK for the past decade. Combined with data from a previous survey [1] we present results from 2007 and consecutive years…
View article: Initial results of the INSPIRE clinical trial—investigating radiation dosimetry for differentiated thyroid cancer patients
Initial results of the INSPIRE clinical trial—investigating radiation dosimetry for differentiated thyroid cancer patients Open
Introduction The optimal strategy for differentiated thyroid cancer (DTC) patients treated with radioiodine (RAI) following thyroidectomy remains controversial. Multi-centre clinical studies are essential to identify strategies to improve …
View article: The Role of Pretherapy Quantitative Imaging and Dosimetry in Radioiodine Therapy for Advanced Thyroid Cancer
The Role of Pretherapy Quantitative Imaging and Dosimetry in Radioiodine Therapy for Advanced Thyroid Cancer Open
Radioactive iodine is well established as a successful treatment for differentiated thyroid cancer (DTC), although around 15% of patients have local recurrence or develop distant metastases and may become refractory to radioactive iodine (…
View article: EANM enabling guide: how to improve the accessibility of clinical dosimetry
EANM enabling guide: how to improve the accessibility of clinical dosimetry Open
Dosimetry can be a useful tool for personalization of molecular radiotherapy (MRT) procedures, enabling the continuous development of theranostic concepts. However, the additional resource requirements are often seen as a barrier to implem…
View article: Milestones in dosimetry for nuclear medicine therapy
Milestones in dosimetry for nuclear medicine therapy Open
Nuclear Medicine therapy has reached a critical juncture with an unprecedented number of patients being treated and an extensive list of new radiopharmaceuticals under development. Since the early applications of these treatments dosimetry…
View article: Joint EANM, SNMMI, and IAEA Enabling Guide: How to Set up a Theranostics Center
Joint EANM, SNMMI, and IAEA Enabling Guide: How to Set up a Theranostics Center Open
The theranostics concept using the same target for both imaging and therapy dates back to the middle of the last century, when radioactive iodine was first used to treat thyroid diseases. Since then, radioiodine has become broadly establis…
View article: Effects of Respiratory Motion on Y-90 PET Dosimetry for SIRT
Effects of Respiratory Motion on Y-90 PET Dosimetry for SIRT Open
Respiratory motion degrades the quantification accuracy of PET imaging by blurring the radioactivity distribution. In the case of post-SIRT PET-CT verification imaging, respiratory motion can lead to inaccuracies in dosimetric measures. Us…
View article: Dosimetry for Radiopharmaceutical Therapy: The European Perspective
Dosimetry for Radiopharmaceutical Therapy: The European Perspective Open
This review presents efforts in Europe over the last few years with respect to standardization of quantitative imaging and dosimetry and comprises the results of several European research projects on practices regarding radiopharmaceutical…
View article: A Systematic Review and Meta-Analysis of the Relationship Between the Radiation Absorbed Dose to the Thyroid and Response in Patients Treated with Radioiodine for Graves' Disease
A Systematic Review and Meta-Analysis of the Relationship Between the Radiation Absorbed Dose to the Thyroid and Response in Patients Treated with Radioiodine for Graves' Disease Open
Background: Patients with Graves' disease are commonly treated with radioiodine. There remains controversy over whether the aim of treatment should be to achieve euthyroidism or hypothyroidism, and whether treatments should be administered…
View article: The internal dosimetry user group position statement on molecular radiotherapy
The internal dosimetry user group position statement on molecular radiotherapy Open
The Internal Dosimetry User Group (IDUG) is an independent, non-profit group of medical professionals dedicated to the promotion of dosimetry in molecular radiotherapy (www.IDUG.org.uk). The Ionising Radiation (Medical Exposure) Regulation…
View article: Comparison of 90Y SIRT predicted and delivered absorbed doses using a PSF conversion method
Comparison of 90Y SIRT predicted and delivered absorbed doses using a PSF conversion method Open
The RCM was successfully verified using phantom data. Analysis of the clinical data established that the 99mTc pre-therapy imaging was predictive of the 90Y absorbed dose to the normal liver to within 20%, but had poor predictability for t…
View article: Adjustment of the iodine ICRP population pharmacokinetic model for the use in thyroid cancer patients after thyroidectomy
Adjustment of the iodine ICRP population pharmacokinetic model for the use in thyroid cancer patients after thyroidectomy Open
Biokinetic models developed for healthy humans are not appropriate to describe biokinetics in thyroid cancer patients following thyroidectomy. The aim of this study was to adjust the population model for iodine proposed by the Internationa…
View article: Additional file 1 of EANM dosimetry committee series on standard operational procedures: a unified methodology for 99mTc-MAA pre- and 90Y peri-therapy dosimetry in liver radioembolization with 90Y microspheres
Additional file 1 of EANM dosimetry committee series on standard operational procedures: a unified methodology for 99mTc-MAA pre- and 90Y peri-therapy dosimetry in liver radioembolization with 90Y microspheres Open
NUMERICAL EXAMPLE
View article: Uncertainty analysis of tumour absorbed dose calculations in Molecular Radiotherapy
Uncertainty analysis of tumour absorbed dose calculations in Molecular Radiotherapy Open
Background: Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment of uncertainty is complicated and, for that reason, it is commonly ignored in clinical ro…
View article: SOLLID – a single centre study to develop methods to investigate the effects of low radiation doses within nuclear medicine, to enable multicentre epidemiological investigations
SOLLID – a single centre study to develop methods to investigate the effects of low radiation doses within nuclear medicine, to enable multicentre epidemiological investigations Open
There is continuing debate concerning the risks of secondary malignancies from low levels of radiation exposure. The current model used for radiation protection is predicated on the assumption that even very low levels of exposure may enta…
View article: Uncertainty analysis of tumour absorbed dose calculations in Molecular Radiotherapy
Uncertainty analysis of tumour absorbed dose calculations in Molecular Radiotherapy Open
Background: Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment of uncertainty is complicated and, for that reason, it is commonly ignored in clinical ro…
View article: Radioactive 3D printing for the production of molecular imaging phantoms
Radioactive 3D printing for the production of molecular imaging phantoms Open
Quality control tests of molecular imaging systems are hampered by the complexity of phantom preparation. It is proposed that radioisotopes can be directly incorporated into photo-polymer resins. Use of the radio-polymer in a 3D printer al…