Jonathan Gehrig
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View article: Somatic STAT5BN642H mutations shape variable immune landscapes resulting in heterogenous immune diseases
Somatic STAT5BN642H mutations shape variable immune landscapes resulting in heterogenous immune diseases Open
Our findings illuminate how a single somatic variant in few stem cells can remodel hematopoiesis, generating variable immune mosaics and heterogeneous immune disease.
View article: Early‐onset, fatal interstitial lung disease in STAT3 gain‐of‐function patients
Early‐onset, fatal interstitial lung disease in STAT3 gain‐of‐function patients Open
Gain‐of‐function variants in STAT3 are known to cause severe, multifaceted autoimmunity. Here we report three individuals with de‐novo STAT3 GOF alleles and early‐onset, severe interstitial lung disease manifesting during the first 3 years…