Jonathan Gigas
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View article: DNA repair and anti-cancer mechanisms in the long-lived bowhead whale
DNA repair and anti-cancer mechanisms in the long-lived bowhead whale Open
At over 200 years, the maximum lifespan of the bowhead whale exceeds that of all other mammals. The bowhead is also the second-largest animal on Earth, reaching over 80,000 kg 1 . Despite its very large number of cells and long lifespan, t…
View article: A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A Open
SUMMARY Sirtuin 6 (SIRT6) is a deacylase and mono-ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in the regulation of aging and metabolism. Targeted sequencing identified a SIRT6 allele containing …
View article: The 2021 FASEB science research conference on NAD metabolism and signaling
The 2021 FASEB science research conference on NAD metabolism and signaling Open
Aging | doi:10.18632/aging.203766. Vera Gorbunova, Marcus Buschbeck, Xiaolu A. Cambronne, Karthikeyani Chellappa, Daniela Corda, Juan Du, Marc Freichel, Jonathan Gigas, Alexander E. Green, Feng Gu, Iva Guberovic, Aravinthkumar Jayabalan, I…
View article: Omics of Long-Lived Mammals and Links to Human Centenarians
Omics of Long-Lived Mammals and Links to Human Centenarians Open
Mammalian species differ up to 100-fold in their aging rates and maximum lifespans. Long-lived mammals appear to possess traits that extend lifespan and healthspan. Pro-longevity mechanisms are complex traits afforded by connections betwee…
View article: Proteomics of Long‐Lived Mammals
Proteomics of Long‐Lived Mammals Open
Mammalian species differ up to 100‐fold in their aging rates and maximum lifespans. Long‐lived mammals appear to possess traits that extend lifespan and healthspan. Genomic analyses have not revealed a single pro‐longevity function that wo…