Jonathan H. Tobias
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View article: The genetic architecture of trabecular bone score and association with fracture: a genome-wide association and meta-analysis
The genetic architecture of trabecular bone score and association with fracture: a genome-wide association and meta-analysis Open
Background Trabecular bone score (TBS) is a texture-based measurement derived from DXA scans, which describes the distribution of mineral across the vertebral bodies. Identifying its genetic determinants is crucial for enhancing understand…
View article: DXA-derived hip shape is associated with hip fracture: a longitudinal study of 38,123 UK Biobank participants
DXA-derived hip shape is associated with hip fracture: a longitudinal study of 38,123 UK Biobank participants Open
Despite advancements in fracture prediction tools and osteoporosis management, hip fractures remain a significant consequence of bone fragility, with a 22% one-year mortality. Hip geometric measures (GMs) have been associated with fracture…
View article: Use of dual-energy X-ray absorptiometry to evaluate variation in bone shape and alignment associated with radiographic knee osteoarthritis: Findings from a study of 19,053 individuals in UK Biobank
Use of dual-energy X-ray absorptiometry to evaluate variation in bone shape and alignment associated with radiographic knee osteoarthritis: Findings from a study of 19,053 individuals in UK Biobank Open
View article: Identification of a novel <i>TGFB1</i> variant in a patient with Camurati-Engelmann disease responsive to alendronate
Identification of a novel <i>TGFB1</i> variant in a patient with Camurati-Engelmann disease responsive to alendronate Open
View article: ABS0835 DOES LONGITUDINAL PATIENT-REPORTED DISEASE ACTIVITY VARY BY GENDER AND AGE IN PATIENTS WITH RHEUMATOID ARTHRITIS
ABS0835 DOES LONGITUDINAL PATIENT-REPORTED DISEASE ACTIVITY VARY BY GENDER AND AGE IN PATIENTS WITH RHEUMATOID ARTHRITIS Open
View article: How and Who? Examining Real‐World Evidence of Engagement and Use of an Electronic Patient‐Reported Outcome Smartphone Application in Routine Clinical Care for Patients With Inflammatory Arthritides
How and Who? Examining Real‐World Evidence of Engagement and Use of an Electronic Patient‐Reported Outcome Smartphone Application in Routine Clinical Care for Patients With Inflammatory Arthritides Open
Objective We evaluate the use of an app to remotely collect electronic patient‐reported outcomes (ePROs) in patients attending routine rheumatology clinics with inflammatory arthritis (IA) over a four year period. Methods This is a seconda…
View article: Editorial: Sex-related differences in bone disease and musculoskeletal health
Editorial: Sex-related differences in bone disease and musculoskeletal health Open
Editorial
View article: Editorial: Insights in bone research: 2023
Editorial: Insights in bone research: 2023 Open
Editorial
View article: LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity
LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity Open
Background WNT signaling plays a key role in postnatal bone formation. Individuals with gain-of-function mutations in the WNT co-receptor LRP5 exhibit increased lower-body fat mass and potentially enhanced glucose metabolism, alongside hig…
View article: Associations between work characteristics and osteoarthritis: A cross-sectional study of 285,947 UK Biobank participants
Associations between work characteristics and osteoarthritis: A cross-sectional study of 285,947 UK Biobank participants Open
View article: COORDINATED VARIATIONS IN HIP SHAPE WITH SEX, AGE AND OA IN UK BIOBANK
COORDINATED VARIATIONS IN HIP SHAPE WITH SEX, AGE AND OA IN UK BIOBANK Open
View article: A novel classifier of radiographic knee osteoarthritis for use on knee DXA images is predictive of joint replacement in UK Biobank
A novel classifier of radiographic knee osteoarthritis for use on knee DXA images is predictive of joint replacement in UK Biobank Open
Objectives DXA scans may offer a novel means of evaluating radiographic knee OA (rKOA) in large population studies and through opportunistic screening. We aimed to develop and apply a semi-automated method for assessing rKOA using ≈20 000 …
View article: The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture
The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture Open
Objectives Hip shape is thought to be an important causal risk factor for hip osteoarthritis and fracture. We aimed to identify genetic determinants of hip shape and use these to assess causal relationships with hip osteoarthritis. Methods…
View article: Implementation of an autonomous mobile platform for agricultural tasks in corridor-like environments
Implementation of an autonomous mobile platform for agricultural tasks in corridor-like environments Open
The role of autonomous vehicles (AVs) in assisting people is recognised and, therefore, is in constant development in numerous fields. Specifically, the ability of an autonomous vehicle (AV) to alleviate global stressors, such as the incre…
View article: Sex differences in the radiographic and symptomatic prevalence of knee and hip osteoarthritis
Sex differences in the radiographic and symptomatic prevalence of knee and hip osteoarthritis Open
Recognising sex differences in disease prevalence can lead to clues as to its pathogenesis, for example the role of hormonal factors and related influences such as body composition, as well as forming the basis for new treatments. However,…
View article: A novel classifier of radiographic knee osteoarthritis for use on knee DXA images is predictive of joint replacement in UK Biobank
A novel classifier of radiographic knee osteoarthritis for use on knee DXA images is predictive of joint replacement in UK Biobank Open
Objectives DXA scans may offer a novel means of evaluating radiographic knee osteoarthritis (rKOA) in large population studies and through opportunistic screening. We aimed to develop and apply a semi-automated method for assessing rKOA us…
View article: Associations between work characteristics and large joint osteoarthritis: a cross-sectional study of 285,947 UK Biobank participants
Associations between work characteristics and large joint osteoarthritis: a cross-sectional study of 285,947 UK Biobank participants Open
Objectives Shift work-induced circadian rhythm disruption has been identified as a risk factor for specific diseases. Additionally, physically demanding work has been linked to osteoarthritis. This study investigated the independent associ…
View article: The proliferation of derivative and redundant studies in endocrinology due to the application of Mendelian Randomisation and other methods to open databases
The proliferation of derivative and redundant studies in endocrinology due to the application of Mendelian Randomisation and other methods to open databases Open
The proliferation of derivative and redundant studies in endocrinology due to the application of Mendelian Randomisation and other methods to open databases
View article: Implementation of autonomous mobile platform for agricultural task in corridor-like environments
Implementation of autonomous mobile platform for agricultural task in corridor-like environments Open
The role of autonomous vehicles (AVs) in assisting people is recognised and, therefore, is in constant development in numerous fields. Specifically, the ability of AV to alleviate global stressors, including an increased potential for food…
View article: Dual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement: Findings from a study of 37,843 people in UK Biobank
Dual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement: Findings from a study of 37,843 people in UK Biobank Open
Using statistical shape modelling, we derived a DXA-based imaging biomarker for knee shape that was associated with kOA progression. When combined with osteophytes and demographic data, this biomarker may help identify individuals at high …
View article: A perspective on muscle phenotyping in musculoskeletal research
A perspective on muscle phenotyping in musculoskeletal research Open
Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarco…
View article: Hip shape shows a causal effect on hip fracture but not hip osteoarthritis: findings from a GWAS meta-analysis and causal analyses
Hip shape shows a causal effect on hip fracture but not hip osteoarthritis: findings from a GWAS meta-analysis and causal analyses Open
Objectives Hip shape is thought to be an important causal risk factor for hip osteoarthritis and fracture. We aimed to identify genetic determinants of hip shape and use these to assess causal relationships with hip osteoarthritis. Methods…
View article: Genome-wide association study of DXA-derived hip morphology identifies associations with 4 loci in Chinese populations
Genome-wide association study of DXA-derived hip morphology identifies associations with 4 loci in Chinese populations Open
Objective To identify genetic factors associated with hip morphology in Chinese populations. Methods An 85-point Statistical Shape Model (SSM) was applied to extract hip shape modes (HSMs). Diameter of the femoral head (DFH), femoral neck …
View article: Femoral neck width genetic risk score is a novel independent risk factor for hip fractures
Femoral neck width genetic risk score is a novel independent risk factor for hip fractures Open
Femoral neck width (FNW) derived from DXA scans may provide a useful adjunct to hip fracture prediction. Therefore, we investigated whether FNW is related to hip fracture risk independently of femoral neck bone mineral density (FN-BMD), us…
View article: Dual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement: findings from a study of 37,843 people in UK Biobank
Dual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement: findings from a study of 37,843 people in UK Biobank Open
Objective We developed a novel imaging biomarker derived from knee dual-energy x-ray absorptiometry (DXA) to predict subsequent total knee replacement (TKR). The biomarker is based on knee shape, determined through statistical shape modell…
View article: Randomised trial of genetic testing and targeted intervention to prevent the development and progression of Paget’s disease of bone
Randomised trial of genetic testing and targeted intervention to prevent the development and progression of Paget’s disease of bone Open
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View article: Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis
Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis Open
rHOA prevalence is lower in Chinese compared with White individuals. Several differences in hip shape were observed, including frequency of cam morphology, FNW, and DFH/FNW ratio. These characteristics have previously been identified as ri…
View article: Editorial: Insights in bone research: 2022
Editorial: Insights in bone research: 2022 Open
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View article: Modelling wine grapevines for autonomous robotic cane pruning
Modelling wine grapevines for autonomous robotic cane pruning Open
Aotearoa (New Zealand) has a strong and growing winegrape industry struggling to access workers to complete skilled, seasonal tasks such as pruning. Maintaining high-producing vines requires training agricultural workers that can make qual…