Jonathan Hetzel
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View article: Dynamic DNA methylation contributes to carryover effects and beneficial acclimatization in geoduck clams
Dynamic DNA methylation contributes to carryover effects and beneficial acclimatization in geoduck clams Open
Given the rapidly changing global climate, there is a growing need to understand the acclimatory basis of animal response to environmental change. To investigate the role of DNA methylation in environmental acclimatization, we generated a …
View article: Genome Sequencing of Sewage Detects Regionally Prevalent SARS-CoV-2 Variants
Genome Sequencing of Sewage Detects Regionally Prevalent SARS-CoV-2 Variants Open
Viral genome sequencing has guided our understanding of the spread and extent of genetic diversity of SARS-CoV-2 during the COVID-19 pandemic. SARS-CoV-2 viral genomes are usually sequenced from nasopharyngeal swabs of individual patients …
View article: The growth–defense pivot: crisis management in plants mediated by LRR-RK surface receptors
The growth–defense pivot: crisis management in plants mediated by LRR-RK surface receptors Open
Plants must adapt to their environment and require mechanisms for sensing their surroundings and responding appropriately. An expanded family of greater than 200 leucine-rich repeat receptor kinases (LRR-RKs) transduces fluctuating and oft…
View article: Genome sequencing of sewage detects regionally prevalent SARS-CoV-2 variants
Genome sequencing of sewage detects regionally prevalent SARS-CoV-2 variants Open
Viral genome sequencing has guided our understanding of the spread and extent of genetic diversity of SARS-CoV-2 during the COVID-19 pandemic. SARS-CoV-2 viral genomes are usually sequenced from nasopharyngeal swabs of individual patients …
View article: Whole-genome and targeted sequencing of drug-resistant Mycobacterium tuberculosis on the iSeq100 and MiSeq: A performance, ease-of-use, and cost evaluation
Whole-genome and targeted sequencing of drug-resistant Mycobacterium tuberculosis on the iSeq100 and MiSeq: A performance, ease-of-use, and cost evaluation Open
The iSeq100 instrument is capable of running existing TB WGS and targeted NGS library preparations with comparable accuracy to the MiSeq. The iSeq100 has reduced sequencing workflow hands-on time and is able to deliver sequencing results i…
View article: RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis
RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis Open
View article: Nascent RNA sequencing reveals distinct features in plant transcription
Nascent RNA sequencing reveals distinct features in plant transcription Open
Significance Transcription is a fundamental and dynamic step in the regulation of gene expression, but the characteristics of plant transcription are poorly understood. We adapted the global nuclear run-on sequencing (GRO-seq) and 5′GRO-se…
View article: Characterization of Arabidopsis thaliana Transcription through an Analysis of Nascent Transcripts
Characterization of Arabidopsis thaliana Transcription through an Analysis of Nascent Transcripts Open
Plant transcription is simultaneously one of the most unique forms of transcription due to the presence of two additional RNA polymerases not found in other eukaryotic species, and one of the least well studied model organisms due to the t…
View article: Cryptochromes Interact Directly with PIFs to Control Plant Growth in Limiting Blue Light
Cryptochromes Interact Directly with PIFs to Control Plant Growth in Limiting Blue Light Open
View article: DOMAINS REARRANGED METHYLTRANSFERASE3 controls DNA methylation and regulates RNA polymerase V transcript abundance in <i>Arabidopsis</i>
DOMAINS REARRANGED METHYLTRANSFERASE3 controls DNA methylation and regulates RNA polymerase V transcript abundance in <i>Arabidopsis</i> Open
Significance DNA methylation, a chemical mark on chromatin, while not affecting DNA's primary sequence, plays important roles in silencing “bad DNA” that would become deleterious to cells if abnormally expressed. This DNA methylation-media…