Jonathan C. Lau
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View article: The Diagnostic Challenge of a False-Positive Cryptococcal Antigen in Chronic Meningitis with Suspected Indolent CNS B-Cell Lymphoproliferative Neoplasm
The Diagnostic Challenge of a False-Positive Cryptococcal Antigen in Chronic Meningitis with Suspected Indolent CNS B-Cell Lymphoproliferative Neoplasm Open
A 47-year-old woman presented with a two-year history of progressive visual symptoms and headaches. Lumbar puncture revealed lymphocytic pleocytosis, elevated protein, low glucose, and a CSF CrAg titer of 1:256. She was treated empirically…
View article: Compositional neural dynamics during reaching
Compositional neural dynamics during reaching Open
The complex mechanics of the arm make the neural control of reaching inherently posture dependent. Because previous reaching studies confound reach direction with final posture, it remains unknown how neural population dynamics in the moto…
View article: Stereo-electroencephalography Performance in Bilateral Independent/Unclear Scalp Seizures
Stereo-electroencephalography Performance in Bilateral Independent/Unclear Scalp Seizures Open
Scalp electroencephalography (EEG) may reveal bilateral independent or unclear (BI/U) ictal onset patterns in patients with focal drug-resistant epilepsy, presenting a challenge to surgical decision-making. The utility of stereo-electroenc…
View article: Model systems for emulating human tissue and physiology in psychiatric research
Model systems for emulating human tissue and physiology in psychiatric research Open
The modeling of psychiatric disorders poses significant challenges due to the complex nature of these conditions, which encompass a range of neuropsychiatric diseases such as autism spectrum disorder (ASD), schizophrenia (SCZ), bipolar dis…
View article: Mapping the topographic organization of the human zona incerta using diffusion MRI
Mapping the topographic organization of the human zona incerta using diffusion MRI Open
The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports the role of the Z…
View article: Mapping the topographic organization of the human zona incerta using diffusion MRI
Mapping the topographic organization of the human zona incerta using diffusion MRI Open
The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports the role of the Z…
View article: The impact of localization and registration accuracy on estimates of deep brain stimulation electrode position in stereotactic space
The impact of localization and registration accuracy on estimates of deep brain stimulation electrode position in stereotactic space Open
Effects of deep brain stimulation (DBS) depend on millimetric accuracy and are commonly studied across populations by registering patient scans to a stereotactic space. Multiple factors contribute to estimates of electrode position, but th…
View article: Prefrontal cortex neuronal ensembles dynamically encode task features during associative memory and virtual navigation
Prefrontal cortex neuronal ensembles dynamically encode task features during associative memory and virtual navigation Open
Neuronal populations expand their information-encoding capacity using mixed selective neurons. This is particularly prominent in association areas such as the lateral prefrontal cortex (LPFC), which integrate information from multiple sens…
View article: The Effect of Selective Dorsal Rhizotomy on Scoliosis in Children With Cerebral Palsy: A Long-term Follow-up Study
The Effect of Selective Dorsal Rhizotomy on Scoliosis in Children With Cerebral Palsy: A Long-term Follow-up Study Open
Background: Selective dorsal rhizotomy (SDR) is commonly used to reduce spasticity in children with cerebral palsy (CP). Children with CP have an increased risk of spinal deformities that increase with age and Gross Motor Function Classifi…
View article: Mapping the topographic organization of the human zona incerta using diffusion MRI
Mapping the topographic organization of the human zona incerta using diffusion MRI Open
The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports the role of the Z…
View article: Comparison of Model Systems for Emulating Human Tissue and Physiology in Psychiatric Research
Comparison of Model Systems for Emulating Human Tissue and Physiology in Psychiatric Research Open
The modeling of psychiatric disorders poses significant challenges due to the complex nature of these conditions, which encompass a range of neuropsychiatric diseases such as autism spectrum disorder (ASD), schizophrenia (SCZ), bipolar dis…
View article: P.079 Relationships between anatomical features and outcome after stereotactic laser amygdalohippocampotomy
P.079 Relationships between anatomical features and outcome after stereotactic laser amygdalohippocampotomy Open
Background: Stereotactic laser amygdalohippocampotomy (SLAH) has recently been shown to be comparable to traditional temporal lobectomy procedures. The ideal extent and volume of laser ablations remains an area of investigation Methods: 65…
View article: Disrupting the epileptogenic network with stereoelectroencephalography‐guided radiofrequency thermocoagulation
Disrupting the epileptogenic network with stereoelectroencephalography‐guided radiofrequency thermocoagulation Open
Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐guided RF‐TC) is a treatment option for focal drug‐resistant epilepsy. In previous studies, this technique has shown seizure reduction by ≥50% in 50% of patients at…
View article: HippoMaps: Multiscale Cartography of Human Hippocampal Organization
HippoMaps: Multiscale Cartography of Human Hippocampal Organization Open
The hippocampus has a unique microarchitecture, is situated at the nexus of multiple macroscale functional networks, contributes to numerous cognitive as well as affective processes, and is highly susceptible to brain pathology across comm…
View article: The impact of localization and registration accuracy on estimates of deep brain stimulation electrode position in stereotactic space
The impact of localization and registration accuracy on estimates of deep brain stimulation electrode position in stereotactic space Open
Effects of deep brain stimulation (DBS) depend on millimetric accuracy and are commonly studied across populations by registering patient scans to a stereotactic space. Multiple factors contribute to estimates of electrode position, but th…
View article: HippoMaps: Multiscale cartography of the human hippocampal formation
HippoMaps: Multiscale cartography of the human hippocampal formation Open
The hippocampus has a unique microarchitecture, is situated at the nexus of multiple macroscale functional networks, contributes to numerous cognitive as well as affective processes, and is highly susceptible to brain pathology across comm…
View article: The past, present, and future of the brain imaging data structure (BIDS)
The past, present, and future of the brain imaging data structure (BIDS) Open
The Brain Imaging Data Structure (BIDS) is a community-driven standard for the organization of data and metadata from a growing range of neuroscience modalities. This paper is meant as a history of how the standard has developed and grown …
View article: Neural Ensembles in the Lateral Prefrontal Cortex Temporally Multiplex Task Features During Virtual Navigation
Neural Ensembles in the Lateral Prefrontal Cortex Temporally Multiplex Task Features During Virtual Navigation Open
Neuronal populations can expand their information encoding capacity using mixed selective neurons. This is particularly prominent in association areas such as the Lateral Prefrontal Cortex (LPFC) that integrate information from multiple se…
View article: The Past, Present, and Future of the Brain Imaging Data Structure (BIDS).
The Past, Present, and Future of the Brain Imaging Data Structure (BIDS). Open
The Brain Imaging Data Structure (BIDS) is a community-driven standard for the organization of data and metadata from a growing range of neuroscience modalities. This paper is meant as a history of how the standard has developed and grown …
View article: Teaching NeuroImage: Unilateral Primary Angiitis of the CNS
Teaching NeuroImage: Unilateral Primary Angiitis of the CNS Open
A 48-year-old woman was referred with an 18-year history of focal-onset seizures. She also reported years-long slowly progressive right-sided weakness that was corroborated on examination. Repeated brain MRIs over 15 years showed multifoca…
View article: The Human Cytomegalovirus Latency-Associated Gene Product Latency Unique Natural Antigen Regulates Latent Gene Expression
The Human Cytomegalovirus Latency-Associated Gene Product Latency Unique Natural Antigen Regulates Latent Gene Expression Open
Human cytomegalovirus (HCMV) infection can lead to either lytic or latent infection, which is dependent on the regulation of the viral major immediate early promoter (MIEP). Suppression of the MIEP is a pre-requisite for latency and is dri…
View article: A population-averaged structural connectomic brain atlas dataset from 422 HCP-aging subjects
A population-averaged structural connectomic brain atlas dataset from 422 HCP-aging subjects Open
Population-averaged brain atlases, that are represented in a standard space with anatomical labels, are instrumental tools in neurosurgical planning and the study of neurodegenerative conditions. Traditional brain atlases are primarily der…
View article: A population-averaged structural connectomic brain atlas of 422 HCP-Aging subjects
A population-averaged structural connectomic brain atlas of 422 HCP-Aging subjects Open
Population-averaged brain atlases, that are represented in a standard space with anatomical labels, are instrumental tools in neurosurgical planning and the study of neurodegenerative conditions. Traditional brain atlases are primarily der…
View article: Automated hippocampal unfolding for morphometry and subfield segmentation with HippUnfold
Automated hippocampal unfolding for morphometry and subfield segmentation with HippUnfold Open
Like neocortical structures, the archicortical hippocampus differs in its folding patterns across individuals. Here, we present an automated and robust BIDS-App, HippUnfold, for defining and indexing individual-specific hippocampal folding…
View article: afids-data: Magnetic resonance imaging datasets with anatomical fiducials for quality control and registration
afids-data: Magnetic resonance imaging datasets with anatomical fiducials for quality control and registration Open
Curated anatomical landmarks placements for common neuroimaging templates and datasets.
View article: afids-data: Magnetic resonance imaging datasets with anatomical fiducials for quality control and registration
afids-data: Magnetic resonance imaging datasets with anatomical fiducials for quality control and registration Open
Curated anatomical landmarks placements for common neuroimaging templates and datasets.
View article: afids-data: Magnetic resonance imaging datasets with anatomical fiducials for quality control and registration
afids-data: Magnetic resonance imaging datasets with anatomical fiducials for quality control and registration Open
Curated anatomical landmarks placements for common neuroimaging templates and datasets.