Jonathan Rodrigues
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View article: CT coronary angiography in the lipid clinic: a pilot study and lipidologist survey
CT coronary angiography in the lipid clinic: a pilot study and lipidologist survey Open
Guidelines recommend considering coronary calcium score (CCS) in asymptomatic patients to aid risk stratification. However, calcification occurs late in atherosclerosis. Coronary CT angiography (CCTA) can detect non-calcific plaque and inf…
View article: Effectiveness of a novel intervention (Super Rehab) in overweight patients with atrial fibrillation (SuRe AF): protocol for a randomised controlled trial
Effectiveness of a novel intervention (Super Rehab) in overweight patients with atrial fibrillation (SuRe AF): protocol for a randomised controlled trial Open
Introduction Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide, associated with significant morbidity, mortality and healthcare utilisation. AF rhythm control strategies demonstrate attrition with time. A number of…
View article: An Indian Cross-Sectional Study to Evaluate In-Clinic Allergic Rhinitis Prevalence in Patients Having Nasal Symptoms Using the SFAR Questionnaire
An Indian Cross-Sectional Study to Evaluate In-Clinic Allergic Rhinitis Prevalence in Patients Having Nasal Symptoms Using the SFAR Questionnaire Open
The in-clinic prevalence of AR in patients with nasal symptoms, as indicated by the SFAR questionnaire, is substantially high in India. A positive family history, indoor dust exposure, nasal symptoms, the months of October to January, and …
View article: Burden of chronic spontaneous urticaria relative to atopic dermatitis and psoriasis in the United States
Burden of chronic spontaneous urticaria relative to atopic dermatitis and psoriasis in the United States Open
After adjusting for confounders, respondents with CSU experienced higher humanistic and economic burden compared with respondents with AD or PSO, indicating a need for new treatments and improved clinical management.
View article: Implementation of a national AI technology program on cardiovascular outcomes and the health system
Implementation of a national AI technology program on cardiovascular outcomes and the health system Open
Coronary artery disease (CAD) is a major cause of ill health and death worldwide. Coronary computed tomographic angiography (CCTA) is the first-line investigation to detect CAD in symptomatic patients. This diagnostic approach risks greate…
View article: Visual ordinal grading of aortic valve calcification on routine non-gated chest CT predicts prognosis and alters management
Visual ordinal grading of aortic valve calcification on routine non-gated chest CT predicts prognosis and alters management Open
Objective BSCI/BSTI guidelines recommend reporting aortic valve calcification (AVC) on all chest CTs regardless of indication. We assessed AVC frequency, severity, and association with aortic stenosis (AS) on echocardiography and its progn…
View article: A systematic review of the role of quantitative CT in the prognostication and disease monitoring of interstitial lung disease
A systematic review of the role of quantitative CT in the prognostication and disease monitoring of interstitial lung disease Open
Background The unpredictable trajectory and heterogeneity of interstitial lung disease (ILDs) make prognostication challenging. Current prognostic indices and outcome measures have several limitations. Quantitative computed tomography (qCT…
View article: Stopping anticoagulation for isolated or incidental subsegmental pulmonary embolism: the challenges and lessons from the STOPAPE RCT
Stopping anticoagulation for isolated or incidental subsegmental pulmonary embolism: the challenges and lessons from the STOPAPE RCT Open
Background The increasing use of computed tomography pulmonary angiography to investigate patients with suspected pulmonary embolism has led to an increase in diagnosis of small subsegmental pulmonary embolism, which is rarely detectable w…
View article: Cerebral blood flow during simulated central hypovolaemia in people with hypertension: does vertebral artery hypoplasia matter?
Cerebral blood flow during simulated central hypovolaemia in people with hypertension: does vertebral artery hypoplasia matter? Open
Adults with hypertension have higher prevalence of vertebral artery hypoplasia (VAH), which is associated with lower resting cerebral blood flow (CBF). We examined whether VAH impacts the ability to regulate CBF during haemodynamic stress …
View article: Interventions that challenge established and accepted clinical practice: lessons learnt from a process evaluation of the STOP-APE trial
Interventions that challenge established and accepted clinical practice: lessons learnt from a process evaluation of the STOP-APE trial Open
Background Developing and implementing interventions that change clinical practice can be challenging and complex. Such interventions can be particularly difficult when attempting to change established behaviours and practices. While exten…
View article: Emergency ECMO Deployment During Liver Transplantation in Portopulmonary Hypertension Patients
Emergency ECMO Deployment During Liver Transplantation in Portopulmonary Hypertension Patients Open
BACKGROUND Portopulmonary hypertension (POPH) is part of Group 1 of the clinical classification of pulmonary hypertension and represents 5-15% of patients with pulmonary hypertension, with a 5-year mortality rate of 40%. The implementation…
View article: Clinical burden, treatment, and disease control in patients with chronic spontaneous urticaria
Clinical burden, treatment, and disease control in patients with chronic spontaneous urticaria Open
Of patients with CSU who were prescribed treatment, more than 50% experienced uncontrolled CSU, which was associated with increased HCRU and health care costs.
View article: Number of inflamed coronary vessels in prediction of cardiac death and MACE among patients undergoing routine CCTA: the Oxford Risk Factors And Non-Invasive Imaging (ORFAN) Study
Number of inflamed coronary vessels in prediction of cardiac death and MACE among patients undergoing routine CCTA: the Oxford Risk Factors And Non-Invasive Imaging (ORFAN) Study Open
Background Coronary inflammation can be assessed by the changes in perivascular adipose tissue on routine coronary CT angiograms (CCTA). Fat attenuation index score (FAI Score) quantifies the degree of inflammation in each epicardial coron…
View article: Coronary artery calcification is prevalent in systemic sclerosis and is associated with adverse prognosis
Coronary artery calcification is prevalent in systemic sclerosis and is associated with adverse prognosis Open
Objective: Coronary artery calcification assessed on thoracic computed tomography represents the calcific component of established coronary artery disease, is a biomarker of total atheromatous plaque burden and predicts mortality. Systemic…
View article: Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK
Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK Open
Background Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial lung disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service in …
View article: Uncertainty quantification in computed tomography pulmonary angiography
Uncertainty quantification in computed tomography pulmonary angiography Open
Computed tomography (CT) imaging of the thorax is widely used for the detection and monitoring of pulmonary embolism (PE). However, CT images can contain artifacts due to the acquisition or the processes involved in image reconstruction. R…
View article: ‘Super Rehab’: can we achieve coronary artery disease regression? A feasibility study protocol
‘Super Rehab’: can we achieve coronary artery disease regression? A feasibility study protocol Open
Introduction Patients diagnosed with coronary artery disease (CAD) are currently treated with medications and lifestyle advice to reduce the likelihood of disease progression and risk of future major adverse cardiovascular events (MACE). W…
View article: Delineating COVID-19 subgroups using routine clinical data identifies distinct in-hospital outcomes
Delineating COVID-19 subgroups using routine clinical data identifies distinct in-hospital outcomes Open
The COVID-19 pandemic has been a great challenge to healthcare systems worldwide. It highlighted the need for robust predictive models which can be readily deployed to uncover heterogeneities in disease course, aid decision-making and prio…