Jonathan K. Stiles
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View article: The NIH Research Centers in Minority Institutions (RCMI): National and Public Health Impact as Measured by Collaborative Scientific Excellence, Investigator Development, and Community Engagement
The NIH Research Centers in Minority Institutions (RCMI): National and Public Health Impact as Measured by Collaborative Scientific Excellence, Investigator Development, and Community Engagement Open
Background: The National Institutes of Health (NIH) established the Research Centers in Minority Institutions (RCMI) Program in response to the Congressional language in House Report 98-911 to establish research centers in predominantly mi…
View article: Investigating SMR Peptide Interactions with Breast Cancer-Associated Proteins
Investigating SMR Peptide Interactions with Breast Cancer-Associated Proteins Open
Breast cancer (BC) is a major cause of cancer-related mortality. Mortalin and Vimentin—two proteins implicated in BC progression and metastasis—have been identified as binding partners of the Secretion Modification Region (SMR) peptide fro…
View article: Science Speed Dating to Spur Inter-Institutional Collaborative Research
Science Speed Dating to Spur Inter-Institutional Collaborative Research Open
A principal strategic goal of the RCMI Coordinating Center (RCMI-CC) is to improve the health of minority populations and to reduce ethnic and geographic disparities in health by coordinating the development and facilitating the implementa…
View article: Hydroxyurea Mitigates Heme-Induced Inflammation and Kidney Injury in Humanized Sickle Cell Mice
Hydroxyurea Mitigates Heme-Induced Inflammation and Kidney Injury in Humanized Sickle Cell Mice Open
Kidney disorders significantly contribute to morbidity and mortality in sickle cell disease (SCD). Acute kidney injury (AKI), a major risk factor for chronic kidney disease (CKD), often arises from intravascular hemolysis, where plasma cel…
View article: Exploring grant writing coaching and its role in professional development of health equity investigators: A qualitative study
Exploring grant writing coaching and its role in professional development of health equity investigators: A qualitative study Open
Introduction: External funding is a critical metric in research career advancement, particularly in biomedical fields. Grant-writing coaching emerges as a strategy in biomedical workforce development. Recognizing disparities in grant succe…
View article: Circulating biomarkers associated with pediatric sickle cell disease
Circulating biomarkers associated with pediatric sickle cell disease Open
Introduction Sickle cell disease (SCD) is a genetic blood disorder caused by a mutation in the HBB gene, which encodes the beta-globin subunit of hemoglobin. This mutation leads to the production of abnormal hemoglobin S (HbS), causing red…
View article: Modulation of Heme-Induced Inflammation Using MicroRNA-Loaded Liposomes: Implications for Hemolytic Disorders Such as Malaria and Sickle Cell Disease
Modulation of Heme-Induced Inflammation Using MicroRNA-Loaded Liposomes: Implications for Hemolytic Disorders Such as Malaria and Sickle Cell Disease Open
Hemolytic disorders, like malaria and sickle cell disease (SCD), are responsible for significant mortality and morbidity rates globally, specifically in the Americas and Africa. In both malaria and SCD, red blood cell hemolysis leads to th…
View article: The Role of Mock Reviewing Sessions in the National Research Mentoring Network Strategic Empowerment Tailored for Health Equity Investigators: A Randomized Controlled Study
The Role of Mock Reviewing Sessions in the National Research Mentoring Network Strategic Empowerment Tailored for Health Equity Investigators: A Randomized Controlled Study Open
The National Research Mentoring Network (NRMN) Strategic Empowerment Tailored for Health Equity Investigators (SETH) study evaluates the value of adding Developmental Network to Coaching in the career advancement of diverse Early-Stage Inv…
View article: Individual and Institutional Factors Contribute to Research Capacity Building for Early-Stage Investigators from Groups Underrepresented in Biomedical Research: A Qualitative Comparative Analysis
Individual and Institutional Factors Contribute to Research Capacity Building for Early-Stage Investigators from Groups Underrepresented in Biomedical Research: A Qualitative Comparative Analysis Open
Background: Enhancement of diversity within the U.S. research workforce is a recognized need and priority at a national level. Existing comprehensive programs, such as the National Research Mentoring Network (NRMN) and Research Centers in …
View article: Sickle Cell Hemoglobin Genotypes Affect Malaria Parasite Growth and Correlate with Exosomal miR-451a and let-7i-5p Levels
Sickle Cell Hemoglobin Genotypes Affect Malaria Parasite Growth and Correlate with Exosomal miR-451a and let-7i-5p Levels Open
Malaria affects a significant portion of the global population, with 247 million cases in 2021, primarily in Africa. However, certain hemoglobinopathies, such as sickle cell trait (SCT), have been linked to lower mortality rates in malaria…
View article: Impact of COVID-19 on the Research Career Advancement of Health Equity Scholars from Diverse Backgrounds
Impact of COVID-19 on the Research Career Advancement of Health Equity Scholars from Diverse Backgrounds Open
The COVID-19 pandemic has significantly taxed scientific research and seems to have exacerbated existing inequities within the research field, particularly for early-stage investigators (ESIs). This study examines the effects of the COVID-…
View article: MiR-451a and let-7i-5p loaded extracellular vesicles attenuate heme-induced inflammation in hiPSC-derived endothelial cells
MiR-451a and let-7i-5p loaded extracellular vesicles attenuate heme-induced inflammation in hiPSC-derived endothelial cells Open
Hemolysis is associated with many pathologies, including trauma, sepsis, hemorrhagic stroke, malaria, and genetic disorders such as sickle cell disease (SCD). When hemolysis occurs, free-heme drives vascular inflammation, resulting in oxid…
View article: Neuregulin-1/ErbB4 signaling modulates Plasmodium falciparum HRP2-induced damage to brain cortical organoids
Neuregulin-1/ErbB4 signaling modulates Plasmodium falciparum HRP2-induced damage to brain cortical organoids Open
Human cerebral malaria (HCM) is a severe complication of Plasmodium falciparum (P.f.) infection that is characterized by capillary occlusions, rupture of the blood-brain barrier (BBB), perivascular cellular injury, and brain swelling. P.f.…
View article: MicroRNAs miR-451a and Let-7i-5p Profiles in Circulating Exosomes Vary among Individuals with Different Sickle Hemoglobin Genotypes and Malaria
MicroRNAs miR-451a and Let-7i-5p Profiles in Circulating Exosomes Vary among Individuals with Different Sickle Hemoglobin Genotypes and Malaria Open
Sickle cell disease (SCD) occurs when two alleles of mutated hemoglobin (HbS or HbC) are inherited (HbSS and HbSC) rather than one (HbAS or HbAC), which indicates a person carries the sickle cell trait. The high prevalence of these two all…
View article: Randomized Controlled Study to Test the Effectiveness of Developmental Network Coaching in the Career Advancement of Diverse Early-Stage Investigators (ESIs): Implementation Challenges and Lessons Learned
Randomized Controlled Study to Test the Effectiveness of Developmental Network Coaching in the Career Advancement of Diverse Early-Stage Investigators (ESIs): Implementation Challenges and Lessons Learned Open
Introduction: Adding developmental networks (DN) to grant-writing coaching can significantly enhance ESIs’ research careers. Herein, we present study design, ESIs’ characteristics and encountered challenges/lessons learned and their resolu…
View article: Effects of Iron Supplements on Heme Scavengers in Pregnancy
Effects of Iron Supplements on Heme Scavengers in Pregnancy Open
In malaria endemic countries, anemia in pregnant women occurs as a result of erythrocyte destruction by Plasmodium infections and other causes including malnutrition. Iron supplementation is recommended as treatment of iron-deficiency anem…
View article: Building a Diverse Workforce and Thinkforce to Reduce Health Disparities
Building a Diverse Workforce and Thinkforce to Reduce Health Disparities Open
The Research Centers in Minority Institutions (RCMI) Program was congressionally mandated in 1985 to build research capacity at institutions that currently and historically recruit, train, and award doctorate degrees in the health professi…
View article: Hemoglobin Genotypes Modulate Inflammatory Response to Plasmodium Infection
Hemoglobin Genotypes Modulate Inflammatory Response to Plasmodium Infection Open
In 2018, 228 million cases and 405,000 malaria-associated deaths were reported worldwide with a majority being in Africa. A wide range of factors, including parasitemia, host immunity, inflammatory responses to infection, and host hemoglob…
View article: Association of EPCR Polymorphism rs867186-GG With Severity of Human Malaria
Association of EPCR Polymorphism rs867186-GG With Severity of Human Malaria Open
Our results indicate that rs867186-GG or rs867186-AG genotypes are not associated with protection against HCM.
View article: Lipoprotein(a) and High Sensitivity C-Reactive Protein among Patients with HIV in Ghana: The Study on Cardiovascular Risk Profile of HIV-Infected Patients on HAART (SCRIPT)
Lipoprotein(a) and High Sensitivity C-Reactive Protein among Patients with HIV in Ghana: The Study on Cardiovascular Risk Profile of HIV-Infected Patients on HAART (SCRIPT) Open
PLWHA in Ghana are associated with higher odds of elevated hs-CRP, regardless of ART use. HIV+ART+ is significantly associated with higher odds of elevated Lp(a) levels compared to HIV+ART-; even after multivariable adjustments. Reasons fo…
View article: Modelling heme-mediated brain injury associated with cerebral malaria in human brain cortical organoids
Modelling heme-mediated brain injury associated with cerebral malaria in human brain cortical organoids Open
Human cerebral malaria (HCM), a severe encephalopathy associated with Plasmodium falciparum infection, has a 20–30% mortality rate and predominantly affects African children. The mechanisms mediating HCM-associated brain injury are difficu…
View article: Cardiovascular risk factors among Ghanaian patients with HIV: A cross‐sectional study
Cardiovascular risk factors among Ghanaian patients with HIV: A cross‐sectional study Open
Background Cardiovascular disease (CVD) poses a significant cause of morbidity and mortality among people living with human immunodeficiency virus (HIV). However, data are limited on CVD risk burden among HIV patients in Ghana. We describe…
View article: Advancing Health Equity through Organizational Mentoring Policies at Minority-Serving Institutions
Advancing Health Equity through Organizational Mentoring Policies at Minority-Serving Institutions Open
Objective: Morehouse School of Medicine, a collaborative partner in the National Research Mentoring Network, established the Mentoring Academy Institutional Planning Forum (MA Forum) to help minority-serving institutions (MSI) optimize re…
View article: PO 8356 ANGIOGENIC AND ANGIOSTATIC FACTORS IN THE SALIVA OF MALARIA PATIENTS
PO 8356 ANGIOGENIC AND ANGIOSTATIC FACTORS IN THE SALIVA OF MALARIA PATIENTS Open
Background Malaria mortality is associated with exaggerated host responses to inflammatory factors such as C-X-C motif chemokine 10 (CXCL10) and host biomarkers such as angiopoietin 1 (Ang-1) and angiopoietin 2 (Ang-2). The aim of this stu…
View article: Global Health Mentoring Toolkits: A Scoping Review Relevant for Low- and Middle-Income Country Institutions
Global Health Mentoring Toolkits: A Scoping Review Relevant for Low- and Middle-Income Country Institutions Open
Capacity building in low- and middle-income country (LMIC) institutions hinges on the delivery of effective mentorship. This study presents an overview of mentorship toolkits applicable to LMIC institutions identified through a scoping rev…
View article: Using a Virtual Community (the Health Equity Learning Collaboratory) to Support Early-Stage Investigators Pursuing Grant Funding
Using a Virtual Community (the Health Equity Learning Collaboratory) to Support Early-Stage Investigators Pursuing Grant Funding Open
Junior investigators often have limited access to networks of scientific experts and resources that facilitate competitive grant submissions. Since environments in which scientists are trained are critically important for long-term success…