Jonathan Knott
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View article: The Impact of Critical Care Quarantine on the Residual Risk of Unexpected Organ Donor Blood-borne Virus Infection
The Impact of Critical Care Quarantine on the Residual Risk of Unexpected Organ Donor Blood-borne Virus Infection Open
Background. The transmission of undetected infections from organ donors to recipients is a persistent concern in transplantation medicine. Despite nucleic acid testing, some infections, especially those acquired recently, may evade detecti…
View article: Music Interventions in Hyperacute and Acute Stroke Patients: A Randomized Controlled Pilot Feasibility Study
Music Interventions in Hyperacute and Acute Stroke Patients: A Randomized Controlled Pilot Feasibility Study Open
Objective Music interventions have been shown to have beneficial effects on hemodynamic parameters, pain, and anxiety in various medical settings. However, music interventions in the setting of acute stroke have not been studied. The objec…
View article: The potential for Safewards to reduce restrictive interventions for people arriving to the emergency Department with police for a mental health assessment
The potential for Safewards to reduce restrictive interventions for people arriving to the emergency Department with police for a mental health assessment Open
The Safewards ED adaptation may have contributed to a reduction in the use of restrictive interventions in this high-risk subgroup of patients frequently subject to restrictive interventions in the ED. Further research is required to valid…
View article: Parenteral medication for the management of acute severe behavioural disturbance (ASBD) in the emergency department
Parenteral medication for the management of acute severe behavioural disturbance (ASBD) in the emergency department Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effectiveness and safety profiles of different parenteral medications for the management of acute severe behavioural disturbance in the e…
View article: Evaluation of a youth-focused suicide prevention HOPE aftercare service: protocol for a non-randomized hybrid effectiveness-implementation type 1 design
Evaluation of a youth-focused suicide prevention HOPE aftercare service: protocol for a non-randomized hybrid effectiveness-implementation type 1 design Open
Background: Suicide is the fourth leading cause of death among young people aged 15–29 worldwide. Young people often present to emergency departments (EDs) with self-harm and suicide related behaviors. The period following discharge from t…
View article: Does a high baseline high sensitivity cardiac troponin T allow for the early diagnosis of acute myocardial infarction?
Does a high baseline high sensitivity cardiac troponin T allow for the early diagnosis of acute myocardial infarction? Open
Background Guidelines suggest that the diagnosis of acute myocardial infarction (MI) is likely when high concentrations of high-sensitivity cardiac troponin (hs-cTn) are present in the initial sample. These concentration thresholds are muc…
View article: Staff perceptions of barriers to self-harm care in the emergency department: A cross-sectional survey study
Staff perceptions of barriers to self-harm care in the emergency department: A cross-sectional survey study Open
Improvements to the ED environment and processes, as well as the provision of regular self-harm specific education and training for all ED staff are needed. Implementation of best-practice standards should prioritise guideline-concordant c…
View article: Pharmacological Emergency management of Agitation in Children and Young people: protocol for a randomised controlled trial of intraMuscular medication (PEAChY-M)
Pharmacological Emergency management of Agitation in Children and Young people: protocol for a randomised controlled trial of intraMuscular medication (PEAChY-M) Open
Introduction Acute severe behavioural disturbance (ASBD) is a condition seen with increasing frequency in emergency departments (EDs) in adults and young people. Despite the increasing number of presentations and significant associated ris…
View article: Pharmacological emergency management of agitation in children and young people: protocol for a randomised controlled trial of oral medication (PEAChY-O)
Pharmacological emergency management of agitation in children and young people: protocol for a randomised controlled trial of oral medication (PEAChY-O) Open
Introduction Acute severe behavioural disturbance (ASBD) is a condition seen with increasing frequency in emergency departments (EDs) in adults and young people. Despite the increasing number of presentations and significant associated ris…
View article: Recently Acquired Blood-borne Virus Infections in Australian Deceased Organ Donors: Estimation of the Residual Risk of Unexpected Transmission
Recently Acquired Blood-borne Virus Infections in Australian Deceased Organ Donors: Estimation of the Residual Risk of Unexpected Transmission Open
Background: Unexpected donor-derived infections of hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV are rare but important potential complications of deceased organ transplantation. The prevalence of recently acquired (yield) infe…
View article: Management of paediatric acute severe behavioural disturbance in emergency departments across Australia: A <scp>PREDICT</scp> survey of senior medical staff
Management of paediatric acute severe behavioural disturbance in emergency departments across Australia: A <span>PREDICT</span> survey of senior medical staff Open
Objective Acute severe behavioural disturbance (ASBD) is a condition seen with increasing frequency in EDs. It poses a significant risk to the patient and those around them. Little is known about the epidemiology or most effective manageme…
View article: Effect of Lower vs Higher Oxygen Saturation Targets on Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest
Effect of Lower vs Higher Oxygen Saturation Targets on Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest Open
Importance The administration of a high fraction of oxygen following return of spontaneous circulation in out-of-hospital cardiac arrest may increase reperfusion brain injury. Objective To determine whether targeting a lower oxygen saturat…
View article: Prevalence of Blood-Borne Viruses and Predictors of Risk in Potential Organ Donors in Australia
Prevalence of Blood-Borne Viruses and Predictors of Risk in Potential Organ Donors in Australia Open
Internationally, the designation of a patient as an increased viral risk organ donor has been associated with lower utilisation rates. The actual prevalence of blood borne viruses in Australian potential organ donors, and the predictive pe…
View article: Remote COVID-19 patient monitoring system: a qualitative evaluation
Remote COVID-19 patient monitoring system: a qualitative evaluation Open
Background Many COVID-19 patients are discharged home from hospital with instructions to self-isolate. This reduces the burden on potentially overwhelmed hospitals. The Royal Melbourne Hospital (RMH) Home Monitoring Programme (HMP) is a mo…
View article: Relation of substance use disorders to mortality, accident and emergency department attendances, and hospital admissions: A 13-year population-based cohort study in Hong Kong
Relation of substance use disorders to mortality, accident and emergency department attendances, and hospital admissions: A 13-year population-based cohort study in Hong Kong Open
SUD was associated with increased mortality, A&E attendances and hospital admissions, especially in school-aged individuals. Our findings suggest prioritising early treatment and preventive interventions for school-aged individuals and foc…
View article: Outcomes for emergency department patients with suspected and confirmed <scp>COVID</scp>‐19: An analysis of the Australian experience in 2020 (<scp>COVED</scp>‐5)
Outcomes for emergency department patients with suspected and confirmed <span>COVID</span>‐19: An analysis of the Australian experience in 2020 (<span>COVED</span>‐5) Open
Objective The aim of the present study was to describe the characteristics and outcomes of patients presenting to Australian EDs with suspected and confirmed COVID‐19 during 2020, and to determine the predictors of in‐hospital death for SA…
View article: Screening major trauma patients for prevalence of illicit drugs
Screening major trauma patients for prevalence of illicit drugs Open
Introduction Australasian emergency departments (ED) routinely test patient alcohol levels following major trauma, but assessment for illicit drugs is uncommon. Methods A prospective cross‐sectional study of major motor‐vehicle‐related tra…
View article: The Snake Study: Survey of National Attitudes and Knowledge in Envenomation
The Snake Study: Survey of National Attitudes and Knowledge in Envenomation Open
Despite recent reviews of best practice for the treatment of Australian venomous bites and stings, there is controversy about some aspects of care, particularly the use of antivenom. Our aim was to understand current attitudes and practice…
View article: Threat of COVID-19 impacting on a quaternary healthcare service: a retrospective cohort study of administrative data
Threat of COVID-19 impacting on a quaternary healthcare service: a retrospective cohort study of administrative data Open
Objectives The threat of a pandemic, over and above the disease itself, may have significant and broad effects on a healthcare system. We aimed to describe the impact of the SARS-CoV-2 pandemic (during a relatively low transmission period)…
View article: Development of a Self-Harm Monitoring System for Victoria
Development of a Self-Harm Monitoring System for Victoria Open
The prevention of suicide and suicide-related behaviour are key policy priorities in Australia and internationally. The World Health Organization has recommended that member states develop self-harm surveillance systems as part of their su…
View article: Epidemiology and clinical features of emergency department patients with suspected <scp>COVID</scp>‐19: Insights from Australia's ‘second wave’ (<scp>COVED</scp>‐4)
Epidemiology and clinical features of emergency department patients with suspected <span>COVID</span>‐19: Insights from Australia's ‘second wave’ (<span>COVED</span>‐4) Open
Objective The aim of the present study was to describe the epidemiology and clinical features of patients presenting to the ED with suspected and confirmed COVID‐19 during Australia's ‘second wave’. Methods The COVID‐19 ED (COVED) Project …
View article: Characteristics and clinical outcomes for mental health patients admitted to a behavioural assessment unit: Implications for model of care and practice
Characteristics and clinical outcomes for mental health patients admitted to a behavioural assessment unit: Implications for model of care and practice Open
Behavioural assessment units (BAU) have been established in emergency departments (EDs) to provide short‐term observation, treatment, and care to people experiencing acute behavioural disturbance. A prospective observational study was cond…
View article: Outcomes of laceration suture repair in the emergency department
Outcomes of laceration suture repair in the emergency department Open
Objective To assess patient satisfaction with laceration management, post‐ED care, cosmesis and complication rates. Methods We undertook a prospective observational study of adult patients with lacerations sutured in two EDs over a 4‐month…
View article: Patients presenting for hospital‐based screening for the coronavirus disease 2019: Risk of disease, and healthcare access preferences
Patients presenting for hospital‐based screening for the coronavirus disease 2019: Risk of disease, and healthcare access preferences Open
Objective Early during the coronavirus disease 2019 (COVID‐19) pandemic, Australian EDs experienced an unprecedented surge in patients seeking screening. Understanding what proportion of these patients require testing and who can be safely…
View article: In Response to “The Novel Use of Home Pulse Oximetry”: An Australian Offer of Support
In Response to “The Novel Use of Home Pulse Oximetry”: An Australian Offer of Support Open
To the Editor, We write to thank Shah et al.1 for sharing their article “Novel Use of Home Pulse Oximetry Monitoring in COVID-19 Patients Discharged From the Emergency Department Identifies Need for Hospitalization” and provide an internat…